scholarly journals FTDP-17 with Pick body-like inclusions associated with a novel tau mutation, p.E372G

2016 ◽  
Vol 27 (5) ◽  
pp. 612-626 ◽  
Author(s):  
Pawel Tacik ◽  
Michael A. DeTure ◽  
Yari Carlomagno ◽  
Wen-Lang Lin ◽  
Melissa E. Murray ◽  
...  
Keyword(s):  
Pick Body ◽  
Tau Mutation

Mechanical Analysis of Warm Extrusion Precision Forming on 42CrMo Steel Cutting Pick

2012 ◽  
Vol 538-541 ◽  
pp. 1061-1066 ◽  
Author(s):  
Chun Jian Su ◽  
Quan Lan Li ◽  
Lin Jing Xiao ◽  
Su Min Guo
Keyword(s):  
New Technology ◽  
Mechanical Analysis ◽  
Extrusion Force ◽  
Factors Affecting ◽  
42Crmo Steel ◽  
Pick Body ◽  
Mining Tool ◽  
Main Factors ◽  
The Cost ◽  
Warm Extrusion

Cutting pick is a kind of widely-used consumptive mining tool. The traditional producing technics of cutting pick body is foundry, or machining after roughly forging, or machining directly from metal bar. By former technics, the property of products is poor, and by latter, the material availability is low and the cost is high. The patent technology for cutting pick body warm extrusion introduced in this paper can overcome all the disadvantages mentioned above. In this paper, by analyzing the characteristic of cutting pick body warm extrusion, adopting the principle of power balance to solve the approximate solution of strain forces, the approximate calculating formulas of extruding power are deduced. The main factors affecting on extrusion force are determined theoretically. This research can be used as basis to design tooling and choose proper equipment for this new technology.

Relationship between circadian period and body size in the tau-mutant golden hamster

2014 ◽  
Vol 92 (1) ◽  
pp. 27-33
Author(s):  
Roberto Refinetti
Keyword(s):  
Body Size ◽  
Single Gene ◽  
Pleiotropic Effect ◽  
Circadian Period ◽  
Golden Syrian Hamster ◽  
Casein Kinase 1 ◽  
Reduced Body ◽  
Short Period ◽  
Casein Kinase 1 Epsilon ◽  
Tau Mutation

The tau mutation in the golden (Syrian) hamster is a single gene mutation that drastically affects the speed of the circadian clock, in such a way that homozygous mutants have an endogenous circadian period of 20 h (compared with 24 h for wild-type hamsters). While studying the circadian system of tau-mutant hamsters during the past 25 years, several authors have noted an apparent relationship between circadian period and body size in these animals. This study, based on 181 hamsters from 24 litters, confirmed previous observations that a shorter circadian period is associated with smaller body size, documented a sex difference in this association, and evaluated several mechanisms that might explain the phenomenon (such as different organ sizes, body composition, and metabolic rate). The obtained evidence suggests that the reduced body size of short-period hamsters is likely a pleiotropic effect of the tau allele (an allele of the casein kinase 1 epsilon gene) rather than a consequence of the shortened circadian period.

Clinical–electrophysiological correlation of tremor and myoclonus in a kindred with the N279K tau mutation

2003 ◽  
Vol 9 (3) ◽  
pp. 151-157 ◽  
Author(s):  
John N Caviness ◽  
Yoshio Tsuboi ◽  
Zbigniew K Wszolek
Keyword(s):  
Tau Mutation

Neuropathology of Pick body disease

2008 ◽  
pp. 415-430 ◽  
Author(s):  
Toshiki Uchihara ◽  
Kuniaki Tsuchiya
Keyword(s):  
Pick Body

Sites of phosphorylation in tau and factors affecting their regulation

2001 ◽  
Vol 67 ◽  
pp. 73-80 ◽  
Author(s):  
Brian H. Anderton ◽  
Joanna Betts ◽  
Walter P. Blackstock ◽  
Jean-Pierre Brion ◽  
Sara Chapman ◽  
...  
Keyword(s):  
Glycogen Synthase ◽  
Principal Component ◽  
Paired Helical Filaments ◽  
Glycogen Synthase Kinase 3 ◽  
P38 Kinase ◽  
Factors Affecting ◽  
Extracellular Signal ◽  
Mitogen Activated Protein ◽  
Tau Mutation

The microtubule-associated protein, tau, is the principal component of paired helical filaments (PHFs) in Alzheimer's disease. PHF-tau is highly phosphorylated and a total of 25 sites of phosphorylation have so far been identified. Many of these sites are serine or threonine residues that are immediately followed in the sequence by proline residues, and hence are candidate phosphorylation sites for proline-directed kinases. In vitro, glycogen synthase kinase-3 (GSK-3), extracellular signal-related kinase-1 and -2, and mitogen-activated protein kinases, p38 kinase and c-jun N-terminal kinase, all phosphorylate many of these sites, although with different efficiencies for particular sites. Phosphorylation studies in transfected cells and neurons show that GSK-3 phosphorylates tau more extensively than do these other proline-directed kinases. Mutations in tau have been shown to affect in vitro phosphorylation of tau by GSK-3. The Arg406-->Trp (R406W) tau mutation also affects tau phosphorylation in cells.

P3-333 Pathological characterization of two FTDP-17 patients carrying a G272V tau mutation

2004 ◽  
Vol 25 ◽  
pp. S450
Author(s):  
Iraad F. Bronner ◽  
Bastiaan C. ter Meulen ◽  
Wouter Kamphorst ◽  
Rivka Ravid ◽  
Peter Heutink ◽  
...  
Keyword(s):  
Tau Mutation

The missing tau mutation: +15 exon 10/intron 10 boundary of MAPT stem loop structure in an Irish family with FTDP-17

2013 ◽  
Vol 333 ◽  
pp. e79
Author(s):  
R. Lonergan ◽  
A. McCarthy ◽  
S. O'Dowd ◽  
B. Magennis ◽  
E. Fallon ◽  
...  
Keyword(s):  
Loop Structure ◽  
Stem Loop ◽  
Stem Loop Structure ◽  
Irish Family ◽  
Tau Mutation ◽  
Exon 10

Frontotemporal dementia and parkinsonism linked to chromosome 17 with the N279K tau mutation

2007 ◽  
Vol 27 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Jerzy Slowinski ◽  
Jake Dominik ◽  
Ryan J. Uitti ◽  
Zeshan Ahmed ◽  
Dennis D. Dickson ◽  
...  
Keyword(s):  
Frontotemporal Dementia ◽  
Chromosome 17 ◽  
Tau Mutation
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