scholarly journals Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia in Frontal Lobe Epilepsy: A New Clinico-Pathological Entity

2016 ◽  
Vol 27 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Johannes Schurr ◽  
Roland Coras ◽  
Karl Rössler ◽  
Tom Pieper ◽  
Manfred Kudernatsch ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Cortical Development ◽  
Frontal Lobe Epilepsy ◽  
Malformation Of Cortical Development

scholarly journals Epileptic Patient with Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy (MOGHE): A Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-5
Author(s):  
A. Verentzioti ◽  
I. Blumcke ◽  
A. Alexoudi ◽  
P. Patrikelis ◽  
A. Siatouni ◽  
...  
Keyword(s):  
Case Report ◽  
White Matter ◽  
Frontal Lobe ◽  
Epileptic Patient ◽  
Focal Epilepsy ◽  
Cortical Development ◽  
Resected Specimen ◽  
Frontal Lobe Epilepsy ◽  
Review Of The Literature ◽  
Malformation Of Cortical Development

Introduction. There is an emerging interest in the literature about MOGHE (Mild Malformation of Cortical Development with Oligodendroglial Hyperplasia and Epilepsy). We report the case of an epileptic patient with MOGHE. Case Report. A 33-year-old male patient was suffering from refractory focal epilepsy since adolescence. MRI demonstrated increased T2/FLAIR signal intensity of right frontal lobe. Presurgical evaluation led to definition of epileptogenic network in a specific area of right frontal lobe. The resected specimen revealed MOGHE. Discussion. MOGHE appears to be a brain entity which shares some unique histopathological features. Review of the literature is in accordance with our patient’s findings. The major neuropathological finding consists of areas with blurred gray-white matter boundaries due to heterotopic neurons in white matter and increased numbers of subcortical oligodendroglial cells with increased proliferation. MR abnormalities are present in T2/FLAIR sequences. It concerns patients with refractory frontal lobe epilepsy and appears to associate with unfavourable postsurgical outcome in seizure control. Conclusion. More cases are needed in order to establish more data about this distinct entity in frontal lobe epilepsy. This could be valuable knowledge to patients and doctors concerning expectations or management of undesirable outcome in frontal lobe epilepsy surgery.

scholarly journals A case of mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE)

2021 ◽  
Vol 12 (3) ◽  
pp. 93-100
Author(s):  
V. S. Khalilov ◽  
A. N. Kislyakov ◽  
T. V. Basalay ◽  
A. V. Levov ◽  
A. A. Kholin
Keyword(s):  
White Matter ◽  
Frontal Lobe ◽  
Focal Cortical Dysplasia ◽  
Epileptiform Activity ◽  
Cortical Development ◽  
Dynamic Mri ◽  
Subtotal Resection ◽  
Pharmacoresistant Epilepsy ◽  
Malformation Of Cortical Development ◽  
The Right

Recently, in the scientist community of specialists dealing with structural epilepsy, it has been noticed an increasing interest in a special form of cortical development disorder not to be included in the ILAE Classification of the epilepsies the 2017 revision. It is so-called mild malformation of cortical development with oligodendroglial hyperplasia and epilepsy (MOGHE). There are a number of publications devoted to the neuroimaging features of MOGHE, which are possible to distinguish from other epileptogenic substrates in comparisons with clinical/anamnestic data and dynamic observation. Our paper describes the case of a patient under 6 years suffering from pharmacoresistant epilepsy with histologically confirmed MOGHE, and having undergone the procedure of epileptic surgery. MRI showed an increased intensity of the T2/FLAIR signal from the white matter in combination with signs of laminar hyperintensivity, regional sulcation disturbance, smoothness of gray-white matter demarcation in the right frontal lobe. A signal intensification from the white matter with the formation similarity of the «transmantl» sign and further pronounced smoothness of the gray-white matter demarcation was observed on dynamic MRI. These changes were estimated as focal cortical dysplasia. Pre-surgical examination revealed a correlation of epileptiform activity with MRI changes. The subtotal resection of the right frontal lobe and the morphological conclusion established the presence of MOGHE was performed.

Presurgical Evaluation in Magnetic Resonance Image-Negative Frontal Lobe Epilepsy

2014 ◽  
Vol 45 (S 01) ◽  
Author(s):  
I. Borggräfe ◽  
C. Vollmar ◽  
A. Lösch ◽  
B. Ertl-Wagner ◽  
L. Gerstl ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Frontal Lobe ◽  
Magnetic Resonance Image ◽  
Frontal Lobe Epilepsy ◽  
Presurgical Evaluation

scholarly journals Mirror writing in a patient with frontal lobe epilepsy

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
Yethindra Vityala ◽  
Tatiana Galako ◽  
Aliya Kadyrova ◽  
Elmira Mamytova ◽  
Anara Toktomametova ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Frontal Lobe Epilepsy ◽  
Mirror Writing

scholarly journals Different Effects of Antiepileptic Drugs on Initiation and Propagation of Ictal Discharges in a Case of Frontal Lobe Epilepsy

Epilepsia ◽  
1998 ◽  
Vol 39 (S5) ◽  
pp. 81-81
Author(s):  
Youji Takeda ◽  
Fumihiro Nakamura ◽  
Masumi Ito ◽  
Yuji Itaichi ◽  
Yoshirou Hayashi ◽  
...  
Keyword(s):  
Frontal Lobe ◽  
Antiepileptic Drugs ◽  
Frontal Lobe Epilepsy ◽  
Initiation And Propagation

scholarly journals Compound heterozygous variants in LAMC3 in association with posterior periventricular nodular heterotopia

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Carla De Angelis ◽  
Alicia B. Byrne ◽  
Rebecca Morrow ◽  
Jinghua Feng ◽  
Thuong Ha ◽  
...  
Keyword(s):  
Cortical Development ◽  
Occipital Cortex ◽  
Compound Heterozygous ◽  
Valuable Insight ◽  
Periventricular Nodular Heterotopia ◽  
Case Presentation ◽  
Malformation Of Cortical Development ◽  
Nodular Heterotopia ◽  
Compound Heterozygous Variants ◽  
Insight Into

Abstract Background Periventricular nodular heterotopia (PNH) is a malformation of cortical development characterized by nodules of abnormally migrated neurons. The cause of posteriorly placed PNH is not well characterised and we present a case that provides insights into the cause of posterior PNH. Case presentation We report a fetus with extensive posterior PNH in association with biallelic variants in LAMC3. LAMC3 mutations have previously been shown to cause polymicrogyria and pachygyria in the occipital cortex, but not PNH. The occipital location of PNH in our case and the proposed function of LAMC3 in cortical development suggest that the identified LAMC3 variants may be causal of PNH in this fetus. Conclusion We hypothesise that this finding extends the cortical phenotype associated with LAMC3 and provides valuable insight into genetic cause of posterior PNH.

scholarly journals Abnormal self-location and vestibular vertigo in a patient with right frontal lobe epilepsy

2010 ◽  
Vol 17 (2) ◽  
pp. 289-292 ◽  
Author(s):  
Christophe Lopez ◽  
Lukas Heydrich ◽  
Margitta Seeck ◽  
Olaf Blanke
Keyword(s):  
Frontal Lobe ◽  
Frontal Lobe Epilepsy ◽  
Vestibular Vertigo
Sign in / Sign up

Export Citation Format

Share Document