scholarly journals St. John's Wort Reduces Beta-Amyloid Accumulation in a Double Transgenic Alzheimer's Disease Mouse Model-Role of P-Glycoprotein

2013 ◽  
Vol 24 (1) ◽  
pp. 18-24 ◽  
Author(s):  
Anja Brenn ◽  
Markus Grube ◽  
Gabriele Jedlitschky ◽  
Andrea Fischer ◽  
Barbara Strohmeier ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Beta Amyloid ◽  
St John’S Wort ◽  
St John's Wort ◽  
P Glycoprotein ◽  
Amyloid Accumulation

β-Lapachone attenuates cognitive impairment and neuroinflammation in beta-amyloid induced mouse model of Alzheimer's disease

2020 ◽  
Vol 81 ◽  
pp. 106300 ◽  
Author(s):  
Narmin Mokarizadeh ◽  
Pouran Karimi ◽  
Marjan Erfani ◽  
Saeed Sadigh-Eteghad ◽  
Nazila Fathi Maroufi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mouse Model ◽  
Beta Amyloid ◽  
Model Of Alzheimer’S Disease

scholarly journals The role of calbindin‐D28k in a mouse model of Down syndrome‐related Alzheimer's disease

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Eric D. Hamlett ◽  
Steven L. Carroll ◽  
Ann‐Charlotte Granholm
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Mouse Model ◽  
Calbindin D28k

O2-11-02: THE ROLE OF SOLUBLE TNF IN METABOLIC DYSFUNCTION AND BBB ALTERATIONS IN A MOUSE MODEL OF ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_12) ◽  
pp. P647-P647
Author(s):  
Malu G. Tansey ◽  
Kathryn P. MacPherson ◽  
Lori N. Eidson ◽  
Mary K. Herrick ◽  
Maria Elizabeth de Sousa Rodrigues ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Metabolic Dysfunction ◽  
Model Of Alzheimer’S Disease

scholarly journals P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Giulia Sita ◽  
Patrizia Hrelia ◽  
Andrea Tarozzi ◽  
Fabiana Morroni
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Therapeutic Drug ◽  
Amyloid A ◽  
P Glycoprotein ◽  
And Function ◽  
The Brain ◽  
Brain Homeostasis

ATP-binding cassette (ABC) transporters, in particular P-glycoprotein (encoded by ABCB1), are important and selective elements of the blood-brain barrier (BBB), and they actively contribute to brain homeostasis. Changes in ABCB1 expression and/or function at the BBB may not only alter the expression and function of other molecules at the BBB but also affect brain environment. Over the last decade, a number of reports have shown that ABCB1 actively mediates the transport of beta amyloid (Aβ) peptide. This finding has opened up an entirely new line of research in the field of Alzheimer’s disease (AD). Indeed, despite intense research efforts, AD remains an unsolved pathology and effective therapies are still unavailable. Here, we review the crucial role of ABCB1 in the Aβtransport and how oxidative stress may interfere with this process. A detailed understanding of ABCB1 regulation can provide the basis for improved neuroprotection in AD and also enhanced therapeutic drug delivery to the brain.

Sign in / Sign up

Export Citation Format

Share Document