The molecular mechanism underlying unconventional secretion of Fibroblast Growth Factor 2 from tumour cells

2017 ◽  
Vol 109 (11) ◽  
pp. 375-380 ◽  
Author(s):  
Julia P. Steringer ◽  
Walter Nickel
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Molecular Mechanism ◽  
Tumour Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Unconventional Secretion

scholarly journals A Direct Role for Phosphatidylinositol-4,5-bisphosphate in Unconventional Secretion of Fibroblast Growth Factor 2

Traffic ◽  
2008 ◽  
Vol 9 (7) ◽  
pp. 1204-1217 ◽  
Author(s):  
Koen Temmerman ◽  
Antje D Ebert ◽  
Hans-Michael Müller ◽  
Irmgard Sinning ◽  
Ivo Tews ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Direct Role ◽  
Unconventional Secretion

scholarly journals Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2

2021 ◽  
Author(s):  
Carola Sparn ◽  
Eleni Dimou ◽  
Annalena Meyer ◽  
Roberto Saleppico ◽  
Sabine Wegehingel ◽  
...  
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Structural Basis ◽  
Limiting Factor ◽  
Fibroblast Growth ◽  
Unconventional Secretion ◽  
Rate Limiting

Fibroblast Growth Factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism. Cell surface heparan sulfate proteoglycans are known to play an essential role in this process. Unexpectedly, we found that among the diverse sub-classes consisting of syndecans, perlecans, glypicans and others, Glypican-1 (GPC1) is both the principle and rate-limiting factor that drives unconventional secretion of FGF2. By contrast, we demonstrate GPC1 to be dispensable for FGF2 signaling into cells. We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Our findings have broad implications for the role of GPC1 as a key molecule in tumor progression.

Fibroblast growth factor 2 induces differentiation and apoptosis of Askin tumour cells

2003 ◽  
Vol 202 (1) ◽  
pp. 103-112 ◽  
Author(s):  
Min-Suk Kim ◽  
Chong Jai Kim ◽  
Hyun Sook Jung ◽  
Mi Ran Seo ◽  
Yong-Sung Juhnn ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Tumour Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth

scholarly journals FGF2 and IL-1β – explorers of unconventional secretory pathways at a glance

2020 ◽  
Vol 133 (21) ◽  
pp. jcs250449
Author(s):  
Maria Teresa Pallotta ◽  
Walter Nickel
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Molecular Mechanisms ◽  
Fibroblast Growth Factor 2 ◽  
Signal Peptides ◽  
Fibroblast Growth ◽  
Biological Functions ◽  
Independent Manner ◽  
Secretory Pathways ◽  
Unconventional Secretion

ABSTRACTFibroblast growth factor 2 (FGF2) and interleukin 1β (IL-1β) were among the earliest examples of a subclass of proteins with extracellular functions that were found to lack N-terminal secretory signal peptides and were shown to be secreted in an ER- and Golgi-independent manner. Many years later, a number of alternative secretory pathways have been discovered, processes collectively termed unconventional protein secretion (UPS). In the course of these studies, unconventional secretion of FGF2 and IL-1β were found to be based upon distinct pathways, mechanisms and molecular machineries. Following a concise introduction into various pathways mediating unconventional secretion and transcellular spreading of proteins, this Cell Science at a Glance poster article aims at a focused analysis of recent key discoveries providing unprecedented detail about the molecular mechanisms and machineries driving FGF2 and IL-1β secretion. These findings are also highly relevant for other unconventionally secreted cargoes that, like FGF2 and IL1β, exert fundamental biological functions in biomedically relevant processes, such as tumor-induced angiogenesis and inflammation.

scholarly journals A Direct Role for ATP1A1 in Unconventional Secretion of Fibroblast Growth Factor 2

2014 ◽  
Vol 290 (6) ◽  
pp. 3654-3665 ◽  
Author(s):  
Sonja Zacherl ◽  
Giuseppe La Venuta ◽  
Hans-Michael Müller ◽  
Sabine Wegehingel ◽  
Eleni Dimou ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Direct Role ◽  
Unconventional Secretion
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