Contemporary outcomes of bladder carcinoma in situ treated with an adequate BCG immunotherapy

2021 ◽  
Author(s):  
José Daniel Subiela ◽  
Óscar Rodríguez Faba ◽  
Júlia Aumatell ◽  
Julio Calderón ◽  
Asier Mercadé ◽  
...  
Keyword(s):  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Bcg Immunotherapy

Cyclin D3 gene amplification in bladder carcinoma in situ

2010 ◽  
Vol 457 (5) ◽  
pp. 555-561 ◽  
Author(s):  
Antonio Lopez-Beltran ◽  
Jose L. Ordóñez ◽  
Ana P. Otero ◽  
Ana Blanca ◽  
Vicky Sevillano ◽  
...  
Keyword(s):  
Gene Amplification ◽  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Cyclin D3

1034 CLINICAL OUTCOMES OF PRIMARY BLADDER CARCINOMA IN SITU IN A CONTEMPORARY SERIES

2010 ◽  
Vol 9 (2) ◽  
pp. 324
Author(s):  
D. Chade ◽  
S.F. Shariat ◽  
G. Godoy ◽  
C. Savage ◽  
A. Cronin ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Primary Bladder

Carcinoma in-situ of the ureter in patients with bladder carcinoma treated by cystectomy

Cancer ◽  
1970 ◽  
Vol 26 (3) ◽  
pp. 583-587 ◽  
Author(s):  
Tara C. Sharma ◽  
Myron R. Melamed ◽  
Willet F. Whitmore
Keyword(s):  
Bladder Carcinoma ◽  
Carcinoma In Situ

Prediction of response to treatment in superficial bladder carcinoma through pattern of interleukin-2 gene expression.

1996 ◽  
Vol 14 (6) ◽  
pp. 1778-1786 ◽  
Author(s):  
R Kaempfer ◽  
L Gerez ◽  
H Farbstein ◽  
L Madar ◽  
O Hirschman ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Mononuclear Cells ◽  
Interleukin 2 ◽  
Response To Treatment ◽  
Tumor Type ◽  
Ifn Gamma ◽  
Superficial Bladder Carcinoma

PURPOSE Superficial bladder carcinoma, treated by resection and intravesical administration of bacillus Calmette-Guérin (BCG), yields a remission rate that approaches 70%. We examined whether expression of interleukin-2 (IL-2) or interferon-gamma (IFN-gamma) genes can serve to predict response. PATIENTS AND METHODS During BCG treatment, we analyzed induction of IL-2 and IFN-gamma mRNA in peripheral-blood mononuclear cells (PBMC) from 73 patients: 51 with papillary tumors and 22 with carcinoma-in-situ (CIS). Results were correlated with remission, relapse, or tumor persistence over a 4-year follow-up period. RESULTS Independent of tumor type, induction of IL-2 mRNA was observed for patients who responded with remission, but not for those who relapsed (P = .0001). Multivariate logistic analysis showed that inducibility of IL-2 mRNA is the discriminating parameter, which yields a predictive value of 97% for remission. Of 23 patients with relapse/persistence, 22 lacked inducibility of IL-2 mRNA (sensitivity, 95.6%), while 35 of 50 patients in remission exhibited inducibility (specificity, 70%). For patients with carcinoma-in-situ, in which remission or failure depends solely on response to BCG, sensitivity and specificity were 88% and 86%, respectively; for patients with papillary tumors, they were 100% and 64%. IFN-gamma mRNA, by contrast, was clearly inducible in PBMC from all patients (P = .51). The disease-free interval increased progressively with inducibility of IL-2 mRNA; this trend was highly significant (P = .0001). CONCLUSION IL-2 gene expression is essential for mounting an antitumor response in superficial bladder carcinoma. Inducibility of IL-2 mRNA is an independent prognostic parameter and useful predictive indicator of remission versus relapse.

THE NATURAL HISTORY OF BLADDER CARCINOMA IN SITU AFTER INITIAL RESPONSE TO BACILLUS CALMETE-GÚERIN IMMUNOTHERAPY

2008 ◽  
Vol 179 (4S) ◽  
pp. 615-615 ◽  
Author(s):  
Ofer N Gofrit ◽  
Dov Pode ◽  
Galina Pizov ◽  
Kevin C Zorn ◽  
Ran Katz ◽  
...  
Keyword(s):  
Natural History ◽  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Initial Response ◽  
History Of

scholarly journals A Common MicroRNA Signature Consisting of miR-133a, miR-139-3p, and miR-142-3p Clusters Bladder Carcinoma in Situ with Normal Umbrella Cells

2013 ◽  
Vol 182 (4) ◽  
pp. 1171-1179 ◽  
Author(s):  
Angela Y. Jia ◽  
Mireia Castillo-Martin ◽  
Josep Domingo-Domenech ◽  
Dennis M. Bonal ◽  
Marta Sánchez-Carbayo ◽  
...  
Keyword(s):  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Umbrella Cells

scholarly journals Clinical Outcomes of Primary Bladder Carcinoma In Situ in a Contemporary Series

2010 ◽  
Vol 184 (1) ◽  
pp. 74-80 ◽  
Author(s):  
Daher C. Chade ◽  
Shahrokh F. Shariat ◽  
Guilherme Godoy ◽  
Caroline J. Savage ◽  
Angel M. Cronin ◽  
...  
Keyword(s):  
Clinical Outcomes ◽  
Bladder Carcinoma ◽  
Carcinoma In Situ ◽  
Primary Bladder
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