scholarly journals Association Between One‐time Prostate‐Specific Antigen (PSA) Test with Free/Total PSA and Prostate Cancer Mortality: A 30‐year Prospective Cohort Study

2021 ◽  
Author(s):  
P‐O Lundgren ◽  
A Kjellman ◽  
U Norming ◽  
O Gustafsson
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Prostate Specific Antigen ◽  
Prospective Cohort Study ◽  
Cancer Mortality ◽  
Prospective Cohort ◽  
Specific Antigen ◽  
Psa Test ◽  
Prostate Cancer Mortality ◽  
Total Psa

Association between dihydrotestosterone and long‐term risk for prostate cancer mortality: A prospective cohort study

The Prostate ◽  
2020 ◽  
Vol 80 (10) ◽  
pp. 777-781
Author(s):  
Per‐Olof Lundgren ◽  
Anders Kjellman ◽  
Ulf Norming ◽  
Ove Gustafsson
Keyword(s):  
Prostate Cancer ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Cancer Mortality ◽  
Prospective Cohort ◽  
Prostate Cancer Mortality

Radical Prostatectomy Versus Observation in Early Prostate Cancer

2021 ◽  
pp. 31-36
Author(s):  
Philipp Dahm
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Prostate Specific Antigen ◽  
Cancer Mortality ◽  
Watchful Waiting ◽  
Specific Antigen ◽  
Prostate Cancer Mortality ◽  
Cancer Group

This chapter provides a summary of the landmark Scandinavian Prostate Cancer Group Study Number 4 trial of men with clinically localized prostate cancer from the pre–prostate-specific antigen (PSA) era who were randomized to radical prostatectomy versus watchful waiting and were followed long term. With follow-up of more than 20 years, the results favored surgery with regard to prostate cancer mortality.

scholarly journals Screening Prostate-specific Antigen Concentration and Prostate Cancer Mortality: The Korean Heart Study

Urology ◽  
2015 ◽  
Vol 85 (5) ◽  
pp. 1111-1116 ◽  
Author(s):  
Yejin Mok ◽  
Heejin Kimm ◽  
Sang Yop Shin ◽  
Sun Ha Jee ◽  
Elizabeth A. Platz
Keyword(s):  
Prostate Cancer ◽  
Prostate Specific Antigen ◽  
Cancer Mortality ◽  
Specific Antigen ◽  
Antigen Concentration ◽  
Prostate Cancer Mortality ◽  
Heart Study

Trajectories of prostate-specific antigen after treatment for prostate cancer

2017 ◽  
Vol 66 (4) ◽  
pp. 768-772
Author(s):  
Ziyue Wu ◽  
Mihaela Aslan ◽  
Haiqun Lin ◽  
John Ko ◽  
Krishnan Radhakrishnan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Prostate Specific Antigen ◽  
Cancer Mortality ◽  
Latent Class ◽  
Proportional Hazards ◽  
Specific Antigen ◽  
Post Treatment ◽  
Curative Intent ◽  
Prostate Cancer Mortality

Prostate-specific antigen (PSA) measurements after primary treatment reflect residual tumor burden among men with prostate cancer. Using a mixture model analysis, we identified distinct trajectories of post-treatment PSA measurements and evaluated their associations with prostate cancer mortality. The study sample included 623 US Veterans treated for prostate cancer with curative intent during 1991–1995; 225 men received surgery and 398 men received radiation therapy. Post-treatment PSA measurements over a 2-year period for each patient were evaluated in latent class mixture models using the SAS TRAJ procedure, and groups of men with distinct trajectories of PSA were identified. These groups were then assessed for associations with 10-year prostate cancer mortality using proportional hazards analysis. Analyses identified three distinct groups—representing patterns of both initial values and changes in PSA over time—after surgery (n=172/31/14) and radiation therapy (n=253/103/22). Men in groups with patterns of higher (compared with the group with lowest) PSA values tended to have worse survival experience: HRs for prostate cancer mortality were 3.45 (P=0.18) and 22.7 (P<0.001) for surgery, and 2.70 (P=0.005) and 18.1 (P<0.001) for radiation therapy. The results indicate that PSA measurements after surgery or radiation therapy with curative intent include groups of men with a diverse spectrum of prognosis for prostate cancer mortality. Although contemporary PSA levels are lower than those observed in the study sample, the corresponding trajectory patterns may become evident shortly after the time of diagnosis and treatment.

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