scholarly journals Impact of enhanced optical techniques at time of TURBT with or without single immediate intravesical chemotherapy on recurrence rate of NMIBC, a systematic review and network meta‐analysis of randomized trials

2021 ◽  
Author(s):  
Reza Sari Motlagh ◽  
Keiichiro Mori ◽  
Ekaterina Laukhtina ◽  
Abdulmajeed Aydh ◽  
Satoshi Katayama ◽  
...  
Keyword(s):  
Systematic Review ◽  
Recurrence Rate ◽  
Randomized Trials ◽  
Meta Analysis ◽  
Intravesical Chemotherapy ◽  
Optical Techniques

scholarly journals Impact of Chemotherapy in the Adjuvant Setting of Early Stage Uterine Leiomyosarcoma: A Systematic Review and Updated Meta-Analysis

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1899
Author(s):  
Alessandro Rizzo ◽  
Margherita Nannini ◽  
Annalisa Astolfi ◽  
Valentina Indio ◽  
Pierandrea De Iaco ◽  
...  
Keyword(s):  
Systematic Review ◽  
Recurrence Rate ◽  
Locoregional Recurrence ◽  
Early Stage ◽  
Meta Analysis ◽  
Distant Recurrence ◽  
Uterine Leiomyosarcoma ◽  
Primary Surgery ◽  
Locoregional Recurrence Rate ◽  
Meta Analyses

Background: Although the use of adjuvant chemotherapy (AC) appears to be increasing over the past few years, several clinical trials and previous meta-analyses failed to determine whether AC could improve clinical outcomes in uterine leiomyosarcoma (uLMS). The aim of this systematic review and meta-analysis was to compare AC (with or without radiotherapy) versus observation (obs) after primary surgery in early stage uLMS. Materials and Methods: Randomized controlled (RCTs) and non-randomized studies (NRSs) were retrieved. Outcomes of interest were as follows: distant recurrence rate, locoregional recurrence rate and overall recurrence rate. Results about distant recurrence rate, locoregional recurrence rate and overall recurrence rate were compared by calculating odds ratios (ORs) with 95% confidence intervals (CIs); ORs were combined with Mantel–Haenszel method. Results: Nine studies were included in the analysis, involving 545 patients (AC: 252, obs: 293). Compared with obs, AC did not reduce locoregional and distant recurrence rate, with a pooled OR of 1.36 and 0.63, respectively. Similarly, administration of AC did not decrease overall recurrence rate in comparison to obs. Conclusion: According to our results, AC (with or without radiotherapy) did not decrease recurrence rate in early stage uLMS; thus, the role of AC in this setting remains unclear.

scholarly journals Systematic Review and Subgroup Meta-analysis of Randomized Trials to Determine Tocilizumab’s Place in COVID-19 Pneumonia

2021 ◽  
Author(s):  
Timothée Klopfenstein ◽  
Vincent Gendrin ◽  
Aurélie Gerazime ◽  
Thierry Conrozier ◽  
Jean-Charles Balblanc ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomized Trials ◽  
Meta Analysis

Renal insufficiency in multiple myeloma: a systematic review and meta-analysis of all randomized trials from 2005–2019

2021 ◽  
pp. 1-13
Author(s):  
Ghulam Rehman Mohyuddin ◽  
Kelly Koehn ◽  
Leyla Shune ◽  
Muhammad Aziz ◽  
Al-Ola Abdallah ◽  
...  
Keyword(s):  
Systematic Review ◽  
Multiple Myeloma ◽  
Renal Insufficiency ◽  
Randomized Trials ◽  
Meta Analysis
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