Survival outcomes for patients with localised upper tract urothelial carcinoma managed with non-definitive treatment

2017 ◽  
Vol 121 (1) ◽  
pp. 124-129 ◽  
Author(s):  
Jamil S. Syed ◽  
Kevin A. Nguyen ◽  
Alfredo Suarez-Sarmiento ◽  
Katelyn Johnson ◽  
Michael S. Leapman ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Definitive Treatment ◽  
Survival Outcomes ◽  
Upper Tract

Ureteral location is associated with survival outcomes in upper tract urothelial carcinoma: A population‐based analysis

2020 ◽  
Vol 27 (11) ◽  
pp. 966-972 ◽  
Author(s):  
Alessandro Veccia ◽  
Alessandro Antonelli ◽  
Alberto Martini ◽  
Ugo Falagario ◽  
Giuseppe Carrieri ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Population Based ◽  
Upper Tract Urothelial Carcinoma ◽  
Survival Outcomes ◽  
Upper Tract

scholarly journals Expression Analysis and Mutational Status of Histone Methyltransferase KMT2D at Different Upper Tract Urothelial Carcinoma Locations

2021 ◽  
Vol 11 (11) ◽  
pp. 1147
Author(s):  
Ekaterina Laukhtina ◽  
Ursula Lemberger ◽  
Andreas Bruchbacher ◽  
Dafina Ilijazi ◽  
Stephan Korn ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Protein Expression ◽  
Urothelial Carcinoma ◽  
Clinical Decision Making ◽  
Histone Methyltransferase ◽  
Tumor Location ◽  
Upper Tract Urothelial Carcinoma ◽  
Survival Outcomes ◽  
Upper Tract ◽  
Mutational Status

The gene coding for histone methyltransferase KMT2D is found among the top mutated genes in upper tract urothelial carcinoma (UTUC); however, there is a lack of data regarding its association with clinicopathologic features as well as survival outcomes. Therefore, we aimed to investigate KMT2D expression, mutation patterns, and their utility as prognostic biomarkers in patients with UTUC. A single-center study was conducted on tumor specimens from 51 patients treated with radical nephroureterectomy (RNU). Analysis of KMT2D protein expression was performed using immunohistochemistry (IHC). Customized next-generation sequencing (NGS) was used to assess alterations in KMT2D exons. Cox regression was used to assess the relationship of KMT2D protein expression and mutational status with survival outcomes. KMT2D expression was increased in patients with a previous history of bladder cancer (25% vs. 0%, p = 0.02). The NGS analysis of KMT2D exons in 27 UTUC tumors revealed a significant association between pathogenic KMT2D variants and tumor location (p = 0.02). Pathogenic KMT2D variants were predominantly found in patients with non-pelvic or multifocal tumors (60% vs. 14%), while the majority of patients with a pelvic tumor location (81% vs. 20%) did not harbor pathogenic KMT2D alterations. Both IHC and NGS analyses of KMT2D failed to detect a statistically significant association between KMT2D protein or KMT2D gene alteration status and clinical variables such as stage/grade of the disease or survival outcomes (all p > 0.05). KMT2D alterations and protein expression were associated with UTUC features such as multifocality, ureteral location, and previous bladder cancer. While KMT2D protein expression and KMT2D mutational status do not seem to have prognostic value in UTUC, they appear to add information to improve clinical decision-making regarding the type of therapy.

MP82-11 SURVIVAL OUTCOMES IN NEOADJUVANT CHEMOTHERAPY FOR HIGH GRADE UPPER TRACT UROTHELIAL CARCINOMA

2020 ◽  
Vol 203 ◽  
pp. e1250
Author(s):  
Aleem Khan* ◽  
Benjamin Taylor ◽  
Bashir Al Hussein Al Awamlh ◽  
Lina Posada Calderon ◽  
Jonathan Fainberg ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Survival Outcomes ◽  
High Grade ◽  
Upper Tract

Survival Outcomes in Neoadjuvant Chemotherapy for High-grade Upper Tract Urothelial Carcinoma: A Nationally Representative Analysis

Urology ◽  
2020 ◽  
Vol 146 ◽  
pp. 158-167
Author(s):  
Aleem I. Khan ◽  
Benjamin L. Taylor ◽  
Bashir Al Hussein Al Awamlh ◽  
Lina Posada Calderon ◽  
Jonathan Fainberg ◽  
...  
Keyword(s):  
Neoadjuvant Chemotherapy ◽  
Urothelial Carcinoma ◽  
Upper Tract Urothelial Carcinoma ◽  
Survival Outcomes ◽  
High Grade ◽  
Upper Tract ◽  
Nationally Representative

Metabolic syndrome and upper tract urothelial carcinoma: A retrospective analysis from a large Chinese cohort.

2019 ◽  
Vol 37 (7_suppl) ◽  
pp. 452-452
Author(s):  
Hang Xu ◽  
Ping Tan ◽  
Lu Yang ◽  
Qiang Wei
Keyword(s):  
Metabolic Syndrome ◽  
Urothelial Carcinoma ◽  
Prediction Models ◽  
Cox Regression ◽  
Density Lipoprotein ◽  
Upper Tract Urothelial Carcinoma ◽  
Survival Outcomes ◽  
Cancer Specific Survival ◽  
Cox Regression Analysis ◽  
Upper Tract

452 Background: Metabolic syndrome (MetS) has been reported to be associated with poor survival outcomes in cancer patients. However, the role of MetS in upper tract urothelial carcinoma (UTUC) has yet to be explored. We aim to investigate the prognostic value of MetS in UTUC after radical nephroureterectomy (RNU). Methods: A total of 644 patients with UTUC after RNU were identified at West China Hospital from May 2003 to December 2016. MetS was defined as the co-existence of three or more of five components (obesity, hypertension, elevated fasting glucose, decreased high-density lipoprotein-cholesterol and hypertriglyceridemia). Logistic and Cox regression analyses was performed to evaluate the associations of MetS with pathological features and survival outcomes. Decision curve analysis was performed to determine the clinical utility of the prediction models. Results: Of 644 patients, 157 (24.4%) had MetS. Over a median follow-up of 39 months, 269 (41.8%) experienced disease recurrence, 233 (36.2%) died and 185 (28.7%) died of UTUC. MetS was independently associated with high-grade disease (odds ratio [OR]: 2.01, P = 0.005), advanced pT stage (≥ pT3, OR: 1.54, P = 0.027) and lymphovascular invasion (OR: 1.71, P = 0.03). Multivariate Cox regression analysis showed that MetS was an independent factor for decreased cancer-specific survival (CSS, HR: 1.38, 95% CI: 1.01-1.89, P = 0.042) but not for RFS (HR: 1.27, 95% CI: 0.97-1.67, P = 0.078) and OS (HR: 1.24, 95% CI: 0.95-1.62, P = 0.121). The estimated c-index of the multivariate models for CSS was 0.763 compared with 0.769 when MetS added. Conclusions: MetS is a negative prognostic factor in UTUC. Further studies of MetS in UTUC are demanded.

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