More key players in the game for myeloma prognosis and therapy

2022 ◽  
Author(s):  
Larry D. Anderson
Keyword(s):  
Key Players

Youth Development in Europe

2009 ◽  
Vol 14 (4) ◽  
pp. 372-375 ◽  
Author(s):  
Katariina Salmela-Aro ◽  
Ingrid Schoon
Keyword(s):  
Young People ◽  
Relationship Quality ◽  
Youth Development ◽  
Social Relationships ◽  
Transition To Adulthood ◽  
Cultural Context ◽  
Integrative Framework ◽  
Reciprocal Interactions ◽  
The Family ◽  
Key Players

A series of six papers on “Youth Development in Europe: Transitions and Identities” has now been published in the European Psychologist throughout 2008 and 2009. The papers aim to make a conceptual contribution to the increasingly important area of productive youth development by focusing on variations and changes in the transition to adulthood and emerging identities. The papers address different aspects of an integrative framework for the study of reciprocal multiple person-environment interactions shaping the pathways to adulthood in the contexts of the family, the school, and social relationships with peers and significant others. Interactions between these key players are shaped by their embeddedness in varied neighborhoods and communities, institutional regulations, and social policies, which in turn are influenced by the wider sociohistorical and cultural context. Young people are active agents, and their development is shaped through reciprocal interactions with these contexts; thus, the developing individual both influences and is influenced by those contexts. Relationship quality and engagement in interactions appears to be a fruitful avenue for a better understanding of how young people adjust to and tackle development to productive adulthood.

The Sino–Russian Strategic Partnership

2018 ◽  
Author(s):  
Paul J. Bolt ◽  
Sharyl N. Cross
Keyword(s):  
The United States ◽  
Strategic Partnership ◽  
Relative Power ◽  
Mutual Respect ◽  
Major Power ◽  
The West ◽  
The World ◽  
Key Players ◽  
Common Interests ◽  
The Relationship

The Conclusion reviews the volume’s major themes. Russia and China have common interests that cement their partnership, and are key players in shaping the international order. Both seek better relations with the West, but on the basis of “mutual respect” and “equality.” While the relationship has grown deeper, particularly since 2014, China and Russia are partners but not allies. Thus, their relationship is marked by burgeoning cooperation, but still areas of potential competition and friction. Russia in particular must deal with China’s growing relative power at the same time that it is isolated from the West. While the Russian–Chinese relationship creates challenges for the United States and Europe and a return of major power rivalry, there is also room for cooperation in the strategic triangle comprising China, Russia, and the West. Looking ahead, the world is in a period of dramatic transition.

scholarly journals Understanding sex differences in long-term blood pressure regulation: insights from experimental studies and computational modeling

2019 ◽  
Vol 316 (5) ◽  
pp. H1113-H1123 ◽  
Author(s):  
Sameed Ahmed ◽  
Rui Hu ◽  
Jessica Leete ◽  
Anita T. Layton
Keyword(s):  
Blood Pressure ◽  
Sex Differences ◽  
Computational Models ◽  
Experimental Studies ◽  
Pressure Control ◽  
Blood Pressure Regulation ◽  
Pressure Regulation ◽  
Physiological Processes ◽  
Key Players

Sex differences in blood pressure and the prevalence of hypertension are found in humans and animal models. Moreover, there has been a recent explosion of data concerning sex differences in nitric oxide, the renin-angiotensin-aldosterone system, inflammation, and kidney function. These data have the potential to reveal the mechanisms underlying male-female differences in blood pressure control. To elucidate the interactions among the multitude of physiological processes involved, one may apply computational models. In this review, we describe published computational models that represent key players in blood pressure regulation, and highlight sex-specific models and their findings.

scholarly journals Signals and Mechanisms Regulating Monocyte and Macrophage Activation in the Pathogenesis of Juvenile Idiopathic Arthritis

2021 ◽  
Vol 22 (15) ◽  
pp. 7960
Author(s):  
Chao-Yi Wu ◽  
Huang-Yu Yang ◽  
Jing-Long Huang ◽  
Jenn-Haung Lai
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Innate Immune System ◽  
Tissue Repair ◽  
Macrophage Activation ◽  
Cell Activation ◽  
Innate Immune ◽  
Inflammatory Joint Diseases ◽  
Tissue Repair And Regeneration ◽  
Related Cell ◽  
Key Players

Monocytes (Mos) and macrophages (Mφs) are key players in the innate immune system and are critical in coordinating the initiation, expansion, and regression of many autoimmune diseases. In addition, they display immunoregulatory effects that impact inflammation and are essential in tissue repair and regeneration. Juvenile idiopathic arthritis (JIA) is an umbrella term describing inflammatory joint diseases in children. Accumulated evidence suggests a link between Mo and Mφ activation and JIA pathogenesis. Accordingly, topics regarding the signals and mechanisms regulating Mo and Mφ activation leading to pathologies in patients with JIA are of great interest. In this review, we critically summarize recent advances in the understanding of how Mo and Mφ activation is involved in JIA pathogenesis and focus on the signaling pathways and mechanisms participating in the related cell activation processes.

scholarly journals Thrombocytopathies: Not Just Aggregation Defects—The Clinical Relevance of Procoagulant Platelets

2021 ◽  
Vol 10 (5) ◽  
pp. 894
Author(s):  
Alessandro Aliotta ◽  
Debora Bertaggia Calderara ◽  
Maxime G. Zermatten ◽  
Matteo Marchetti ◽  
Lorenzo Alberio
Keyword(s):  
Platelet Activation ◽  
Clinical Relevance ◽  
Current Knowledge ◽  
Procoagulant Activity ◽  
Key Players ◽  
Platelet Defects

Platelets are active key players in haemostasis. Qualitative platelet dysfunctions result in thrombocytopathies variously characterized by defects of their adhesive and procoagulant activation endpoints. In this review, we summarize the traditional platelet defects in adhesion, secretion, and aggregation. In addition, we review the current knowledge about procoagulant platelets, focusing on their role in bleeding or thrombotic pathologies and their pharmaceutical modulation. Procoagulant activity is an important feature of platelet activation, which should be specifically evaluated during the investigation of a suspected thrombocytopathy.

scholarly journals Microfluidic chip grafted with integrin tension sensors for evaluating the effects of flowing shear stress and ROCK inhibitor on platelets

Lab on a Chip ◽  
2021 ◽  
Author(s):  
Subin Mao ◽  
Anwesha Sarkar ◽  
Yongliang Wang ◽  
Chao Song ◽  
Dana Nicole LeVine ◽  
...  
Keyword(s):  
Shear Stress ◽  
Microfluidic Chip ◽  
Platelet Adhesion ◽  
Rock Inhibitor ◽  
Platelet Adhesion And Aggregation ◽  
Key Players

Integrins are key players in platelet adhesion and aggregation. Integrin molecular tensions, the forces transmitted by integrin molecules, are regulated by both mechanical and biochemical cues, and the outside-in and...

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