Identification of a novel GOLGA4–JAK2 fusion gene in B‐cell acute lymphoblastic leukaemia

2021 ◽  
Author(s):  
Charlotte E. J. Downes ◽  
Jacqueline Rehn ◽  
Susan L. Heatley ◽  
David Yeung ◽  
Barbara J. McClure ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Fusion Gene

scholarly journals Clinker: visualising fusion genes detected in RNA-seq data

2017 ◽  
Author(s):  
Breon M Schmidt ◽  
Nadia M Davidson ◽  
Anthony DK Hawkins ◽  
Ray Bartolo ◽  
Ian J Majewski ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Fusion Gene ◽  
Therapeutic Targets ◽  
Genomic Profiling ◽  
Fusion Genes ◽  
Rna Seq ◽  
Bioinformatics Tool ◽  
Rich Diversity

ABSTRACTGenomic profiling efforts have revealed a rich diversity of oncogenic fusion genes, and many are emerging as important therapeutic targets. While there are many ways to identify fusion genes from RNA-seq data, visualising these transcripts and their supporting reads remains challenging. Clinker is a bioinformatics tool written in Python, R and Bpipe, that leverages the superTranscript method to visualise fusion genes. We demonstrate the use of Clinker to obtain interpretable visualisations of the RNA-seq data that lead to fusion calls. In addition, we use Clinker to explore multiple fusion transcripts with novel breakpoints within the P2RY8-CRLF2 fusion gene in B-cell Acute Lymphoblastic Leukaemia (B-ALL).Availability and ImplementationClinker is freely available from Github https://github.com/Oshlack/Clinker under a MIT [email protected]

Mature B-cell acute lymphoblastic leukaemia associated with a rare MLL-FOXO4 fusion gene

2012 ◽  
Vol 157 (6) ◽  
pp. 651-651 ◽  
Author(s):  
Leon Lim ◽  
Kok-Siong Chen ◽  
Shekhar Krishnan ◽  
Leena Gole ◽  
Hany Ariffin
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Fusion Gene

Screening for the P2RY8-CRLF2 fusion gene in childhood acute lymphoblastic leukaemia

2011 ◽  
Vol 223 (03) ◽  
Author(s):  
M Morak ◽  
R Joas ◽  
S Fischer ◽  
A Attarbaschi ◽  
G Mann ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Fusion Gene ◽  
Childhood Acute Lymphoblastic Leukaemia

CKLF and IL1B transcript levels at diagnosis are predictive of relapse in children with pre‐B‐cell acute lymphoblastic leukaemia

2021 ◽  
Vol 193 (1) ◽  
pp. 171-175
Author(s):  
Stephen Fitter ◽  
Alanah L. Bradey ◽  
Chung Hoow Kok ◽  
Jacqueline E. Noll ◽  
Vicki J. Wilczek ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Transcript Levels

Detection of dicentric chromosome (9;20) in paediatric B-cell acute lymphoblastic leukaemia: prognostic significance

2014 ◽  
Vol 94 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Mathilde Letouzey ◽  
Dominique Penther ◽  
Catherine Roche-Lestienne ◽  
Brigitte Nelken ◽  
Catherine Devoldère ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
B Cell ◽  
Lymphoblastic Leukaemia ◽  
Prognostic Significance ◽  
Dicentric Chromosome
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