scholarly journals Guideline development for prevention of transfusion‐associated graft‐ versus ‐host disease: reduction of indications for irradiated blood components after prestorage leukodepletion of blood components

2021 ◽  
Author(s):  
Johanna C. Wiersum‐Osselton ◽  
Jennichjen Slomp ◽  
J. H. Frederik Falkenburg ◽  
Tessa Geltink ◽  
Hans L. P. Duijnhoven ◽  
...  
Keyword(s):  
Graft Versus Host Disease ◽  
Guideline Development ◽  
Blood Components ◽  
Host Disease ◽  
Graft Versus Host ◽  
Disease Reduction

Guidelines on gamma irradiation of blood components for the prevention of transfusion-associated graft-versus-host disease

1996 ◽  
Vol 6 (3) ◽  
pp. 261-271 ◽  
Author(s):  
J. Chapman ◽  
R. D. Finney ◽  
K. Forman ◽  
P. Kelsey ◽  
S. M. Knowles ◽  
...  
Keyword(s):  
Gamma Irradiation ◽  
Graft Versus Host Disease ◽  
Blood Components ◽  
Host Disease ◽  
Graft Versus Host

scholarly journals Transfusion-associated graftversus- host disease: A brief comment on blood safety

2021 ◽  
Vol 13 (3) ◽  
Author(s):  
Palma Manduzio
Keyword(s):  
Graft Versus Host Disease ◽  
Blood Components ◽  
Blood Safety ◽  
Host Disease ◽  
Graft Versus Host ◽  
Vulnerable Patients

Dear Editor, A recent paper from Dr Elliot published in Transfusion, entitled ‘Missed irradiation of cellular blood components from vulnerable patients: Insight from 10 years of SHOT data’ updates on Transfusion-associated graft-versus-host disease and blood safety [...].

Transfusion associated graft-versus-host disease in DiGeorge syndrome—index case report with survey of screening procedures and use of irradiated blood components

1996 ◽  
Vol 6 (3) ◽  
pp. 222-227 ◽  
Author(s):  
Rodney C. G. Franklin ◽  
Obed Onuzo ◽  
Paul A. Miller ◽  
David Goldblatt ◽  
David Cummins
Keyword(s):  
Graft Versus Host Disease ◽  
Digeorge Syndrome ◽  
Screening Method ◽  
Disease Assessment ◽  
Blood Components ◽  
Host Disease ◽  
Graft Versus Host ◽  
The United Kingdom ◽  
The Republic ◽  
High Level

SummaryMost patients with DiGeorge syndrome require surgery to their heart defect during infancy and are at risk of developing transfusion-associated graft-versus-host disease if non-irradiated blood is used perioperatively. Because of its wide clinical variability, DiGeorge syndrome may not be recognized before surgery and thus a high level of vigilance is required. An infant is described who developed fatal graft-versus-host disease after receiving non-irradiated blood components during surgery for classical tetralogy of Fallot; the postoperative clinical course and autopsy findings were consistent with underlying DiGeorge syndrome. An informal survey of the 18 pediatric cardiology units in the United Kingdom and the Republic of Ireland showed no consensus as to which patients should be screened for DiGeorge syndrome, which screening test to use and to whom irradiated blood components should or should not be given to prevent transfusion associated graft-versus-host disease. Assessment of T-cell numbers appears to be the preferred screening method to determine those who might benefit from receiving such therapy.

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