scholarly journals Clinical characteristics of human platelet antigen (HPA)‐1a and HPA‐5b alloimmunised pregnancies and the association between platelet HPA‐5b antibodies and symptomatic fetal neonatal alloimmune thrombocytopenia

2021 ◽  
Author(s):  
Thijs W. de Vos ◽  
Leendert Porcelijn ◽  
Suzanne Hofstede‐van Egmond ◽  
Eva Pajkrt ◽  
Dick Oepkes ◽  
...  
Keyword(s):  
Clinical Characteristics ◽  
Human Platelet ◽  
Platelet Antigen ◽  
Human Platelet Antigen ◽  
Alloimmune Thrombocytopenia

Human platelet antigen typing of neonatal alloimmune thrombocytopenia patients using whole genome amplified DNA and a 5′-nuclease assay

Transfusion ◽  
2009 ◽  
Vol 49 (5) ◽  
pp. 953-958 ◽  
Author(s):  
Alina G. Lemnrau ◽  
Sandra Cardoso ◽  
Lisa E. Creary ◽  
Colin Brown ◽  
Marcos Miretti ◽  
...  
Keyword(s):  
Human Platelet ◽  
Whole Genome ◽  
Platelet Antigen ◽  
Human Platelet Antigen ◽  
Alloimmune Thrombocytopenia ◽  
Nuclease Assay

Neonatal alloimmune thrombocytopenia caused by an antibody specific for a newly identified allele of human platelet antigen-7

Transfusion ◽  
2010 ◽  
Vol 50 (6) ◽  
pp. 1276-1284 ◽  
Author(s):  
Yangsook Koh ◽  
Atsuko Taniue ◽  
Hiroyuki Ishii ◽  
Nobuki Matsuyama ◽  
Etsuko Amakishi ◽  
...  
Keyword(s):  
Human Platelet ◽  
Platelet Antigen ◽  
Human Platelet Antigen ◽  
Alloimmune Thrombocytopenia

A Screening and Intervention Program Reducing Mortality and Serious Morbidity Associated with Neonatal Alloimmune Thrombocytopenia.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 1232-1232
Author(s):  
Jens Kjeldsen-Kragh ◽  
Mette K. Killie ◽  
Geir Tomter ◽  
Elzbieta Golebiowska ◽  
Helene Pedersen ◽  
...  
Keyword(s):  
Platelet Count ◽  
Intervention Program ◽  
Human Platelet ◽  
Fetal Brain ◽  
University Hospital ◽  
Severe Thrombocytopenia ◽  
Platelet Antigen ◽  
Human Platelet Antigen ◽  
Alloimmune Thrombocytopenia

Abstract Background: Neonatal alloimmune thrombocytopenia (NAIT) is most frequently caused by antibodies against the human platelet antigen (HPA) 1a. The objective of the present study was to identify HPA 1a negative women, and to offer them an intervention program aimed to reduce morbidity and mortality of NAIT. Methods: A total of 100,448 pregnant women were HPA 1 typed. The HPA 1a negative women were screened for anti-HPA 1a, which was quantified when present. Immunized women were referred to a university hospital for clinical follow-up, including ultrasonographic examination of the fetal brain. Caesarean section was performed 2–4 weeks prior to term with platelets from HPA 1bb donors reserved for immediate transfusion if petechiae were present and/or if platelet count was < 35 × 109/L. Results: Of all women typed 2.1% were HPA 1a negative. Anti-HPA 1a was detected in 210 of 1,990 HPA 1a negative women. A total of 170 pregnancies in 154 HPA 1a negative women were managed according to the intervention program. These women gave birth to 161 HPA 1a positive children of whom 55 had severe thrombocytopenia (<50 × 109/L) including two with ICH. There were no intrauterine deaths. In 13 previously published prospective studies comprising 131,465 women of whom 2,290 were HPA 1a negative, there were 10 cases with severe NAIT-related complications (3 intrauterine deaths and 7 neonates with ICH), which are significantly higher than in our study (p < 0.05). Conclusions: The screening and intervention program seems to reduce mortality and serious morbidity associated with NAIT.

scholarly journals Anti-Human Platelet Antigen-1a Immunoglobulin G Preparation Intended to Prevent Fetal and Neonatal Alloimmune Thrombocytopenia

PLoS ONE ◽  
2016 ◽  
Vol 11 (9) ◽  
pp. e0162973 ◽  
Author(s):  
Ying-Jan Weng ◽  
Anne Husebekk ◽  
Björn Skogen ◽  
Mette Kjaer ◽  
Liang-Tzung Lin ◽  
...  
Keyword(s):  
Immunoglobulin G ◽  
Human Platelet ◽  
Platelet Antigen ◽  
Human Platelet Antigen ◽  
Alloimmune Thrombocytopenia

HLA-DRB3*01:01 is a predictor of immunization against human platelet antigen-1a but not of the severity of fetal and neonatal alloimmune thrombocytopenia

Transfusion ◽  
2016 ◽  
Vol 57 (3) ◽  
pp. 533-540 ◽  
Author(s):  
Sandra Wienzek-Lischka ◽  
Inke R. König ◽  
Eva-Maria Papenkort ◽  
Holger Hackstein ◽  
Sentot Santoso ◽  
...  
Keyword(s):  
Human Platelet ◽  
Platelet Antigen ◽  
Human Platelet Antigen ◽  
Alloimmune Thrombocytopenia
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