Cerebral and skeletal muscle tissue oxygenation during exercise challenge in children and young adults with sickle cell anaemia

2021 ◽  
Author(s):  
Christina M. Barriteau ◽  
Abraham Chiu ◽  
Mark Rodeghier ◽  
Robert I. Liem
Keyword(s):  
Skeletal Muscle ◽  
Young Adults ◽  
Sickle Cell ◽  
Muscle Tissue ◽  
Sickle Cell Anaemia ◽  
Tissue Oxygenation ◽  
Skeletal Muscle Tissue ◽  
Exercise Challenge ◽  
Children And Young Adults

scholarly journals Developmental Profile of Sleep and Its Potential Impact on Daytime Functioning from Childhood to Adulthood in Sickle Cell Anaemia

2020 ◽  
Vol 10 (12) ◽  
pp. 981
Author(s):  
Melanie Kölbel ◽  
Fenella J. Kirkham ◽  
Dagmara Dimitriou
Keyword(s):  
Young Adults ◽  
Sickle Cell ◽  
Sleep Disturbances ◽  
Sickle Cell Anaemia ◽  
Limb Movement ◽  
Sleep Onset Latency ◽  
Sleep Habits ◽  
Daytime Functioning ◽  
Children And Young Adults ◽  
Night Waking

Young individuals with sickle cell anaemia (SCA) experience sleep disturbances and often experience daytime tiredness, which in turn may impact on their daytime functioning and academic attainment, but there are few longitudinal data. Methods: Data on sleep habits and behaviour were taken on the same day as an in-hospital polysomnography. This study assesses the developmental sleep profiles of children and young adults aged 4–23 years old with SCA. We examined retrospective polysomnography (PSG) and questionnaire data. Results: A total of 256 children with a median age of 10.67 years (130 male) were recruited and 179 returned for PSG 1.80–6.72 years later. Later bedtimes and a decrease in total sleep time (TST) were observed. Sleep disturbances, e.g., parasomnias and night waking, were highest in preschool children and young adults at their first visit. Participants with lower sleep quality, more movement during the night and increased night waking experienced daytime sleepiness, potentially an indicator of lower daytime functioning. Factors influencing sleep quantity included age, hydroxyurea prescription, mean overnight oxygen saturation, sleep onset latency, periodic limb movement, socioeconomic status and night waking. Conclusion: Sleep serves an important role for daytime functioning in SCA; hence, quantitative (i.e., PSG for clinical symptoms, e.g., sleep-disordered breathing, nocturnal limb movement) and qualitative (i.e., questionnaires for habitual sleep behaviour) assessments of sleep should be mutually considered to guide interventions.

scholarly journals Some Experiences in Managing Sickle-cell Anaemia in Children and Young Adults, Using Alkalis and Magnesium

BMJ ◽  
1964 ◽  
Vol 2 (5403) ◽  
pp. 226-229 ◽  
Author(s):  
K. Hugh-Jones ◽  
H. Lehmann ◽  
J. M. McAlister
Keyword(s):  
Young Adults ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Children And Young Adults

scholarly journals The acute phase inflammatory response to maximal exercise testing in children and young adults with sickle cell anaemia

2015 ◽  
Vol 171 (5) ◽  
pp. 854-861 ◽  
Author(s):  
Robert I. Liem ◽  
Kasiemobi Onyejekwe ◽  
Marie Olszewski ◽  
Chisalu Nchekwube ◽  
Frank P. Zaldivar ◽  
...  
Keyword(s):  
Young Adults ◽  
Inflammatory Response ◽  
Sickle Cell ◽  
Acute Phase ◽  
Exercise Testing ◽  
Sickle Cell Anaemia ◽  
Maximal Exercise ◽  
Children And Young Adults

scholarly journals Comparison of regional skeletal muscle tissue oxygenation in college athletes and sedentary control subjects using quantitative BOLD MR imaging

2016 ◽  
Vol 4 (16) ◽  
pp. e12903 ◽  
Author(s):  
Mitchel R. Stacy ◽  
Christopher M. Caracciolo ◽  
Maolin Qiu ◽  
Prasanta Pal ◽  
Tyler Varga ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mr Imaging ◽  
Muscle Tissue ◽  
College Athletes ◽  
Tissue Oxygenation ◽  
Skeletal Muscle Tissue ◽  
Sedentary Control ◽  
Control Subjects

scholarly journals Recycled algae-based carbon materials as electroconductive 3D printed skeletal muscle tissue engineering scaffolds

2021 ◽  
Vol 32 (7) ◽  
Author(s):  
Selva Bilge ◽  
Emre Ergene ◽  
Ebru Talak ◽  
Seyda Gokyer ◽  
Yusuf Osman Donar ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Tissue Engineering ◽  
Electrical Stimulation ◽  
Muscle Tissue ◽  
Carbonaceous Material ◽  
Hydrothermal Carbonization ◽  
Skeletal Muscle Tissue ◽  
Myotube Formation ◽  
3D Printed

AbstractSkeletal muscle is an electrically and mechanically active tissue that contains highly oriented, densely packed myofibrils. The tissue has self-regeneration capacity upon injury, which is limited in the cases of volumetric muscle loss. Several regenerative therapies have been developed in order to enhance this capacity, as well as to structurally and mechanically support the defect site during regeneration. Among them, biomimetic approaches that recapitulate the native microenvironment of the tissue in terms of parallel-aligned structure and biophysical signals were shown to be effective. In this study, we have developed 3D printed aligned and electrically active scaffolds in which the electrical conductivity was provided by carbonaceous material (CM) derived from algae-based biomass. The synthesis of this conductive and functional CM consisted of eco-friendly synthesis procedure such as pre-carbonization and multi-walled carbon nanotube (MWCNT) catalysis. CM obtained from biomass via hydrothermal carbonization (CM-03) and its ash form (CM-03K) were doped within poly(ɛ-caprolactone) (PCL) matrix and 3D printed to form scaffolds with aligned fibers for structural biomimicry. Scaffolds were seeded with C2C12 mouse myoblasts and subjected to electrical stimulation during the in vitro culture. Enhanced myotube formation was observed in electroactive groups compared to their non-conductive counterparts and it was observed that myotube formation and myotube maturity were significantly increased for CM-03 group after electrical stimulation. The results have therefore showed that the CM obtained from macroalgae biomass is a promising novel source for the production of the electrically conductive scaffolds for skeletal muscle tissue engineering.

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