The promise and role of point of care testing to reduce the global burden of sickle cell disease through early diagnosis and linkage to care

2021 ◽  
Author(s):  
Daniel Dexter ◽  
Patrick T. McGann
Keyword(s):  
Sickle Cell Disease ◽  
Early Diagnosis ◽  
Sickle Cell ◽  
Point Of Care ◽  
Linkage To Care ◽  
Global Burden ◽  
Cell Disease ◽  
Point Of Care Testing

Preliminary Evaluation of a Point-of-Care Testing Device (SickleSCAN™) in Screening for Sickle Cell Disease

Hemoglobin ◽  
2017 ◽  
Vol 41 (2) ◽  
pp. 77-82 ◽  
Author(s):  
Maxwell M. Nwegbu ◽  
Hezekiah A. Isa ◽  
Biyaya B. Nwankwo ◽  
Chinedu C. Okeke ◽  
Uduak J. Edet-Offong ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Point Of Care ◽  
Preliminary Evaluation ◽  
Testing Device ◽  
Cell Disease ◽  
Point Of Care Testing

scholarly journals Newborn Screening for Sickle Cell Disease Using Point-of-Care Testing in Low-Income Setting

PEDIATRICS ◽  
2019 ◽  
Vol 144 (4) ◽  
pp. e20184105 ◽  
Author(s):  
Ofelia A. Alvarez ◽  
Tally Hustace ◽  
Mimose Voltaire ◽  
Alejandro Mantero ◽  
Ulrick Liberus ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Newborn Screening ◽  
Sickle Cell ◽  
Low Income ◽  
Point Of Care ◽  
Cell Disease ◽  
Point Of Care Testing ◽  
Low Income Setting

scholarly journals Validation of a novel point of care testing device for sickle cell disease

BMC Medicine ◽  
2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Julie Kanter ◽  
Marilyn J. Telen ◽  
Carolyn Hoppe ◽  
Christopher L. Roberts ◽  
Jason S. Kim ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Point Of Care ◽  
Testing Device ◽  
Cell Disease ◽  
Point Of Care Testing

scholarly journals Diagnostic Accuracy of HemotypeSC as a Point-of-Care Testing Device for Sickle Cell Disease: Findings from a Southwestern State in Nigeria and Implications for Patient Care in Resource-Poor Settings of sub-Saharan Africa

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110167
Author(s):  
Oladele S. Olatunya ◽  
Dulcinea M. Albuquerque ◽  
Adeniyi F. Fagbamigbe ◽  
Opeyemi A. Faboya ◽  
Ayotunde E. Ajibola ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sensitivity And Specificity ◽  
Sickle Cell ◽  
Point Of Care ◽  
Sub Saharan Africa ◽  
Testing Device ◽  
Cell Disease ◽  
Point Of Care Testing ◽  
Predictive Values ◽  
Sub Saharan

This study aimed to determine the performance of a rapid, point-of-care testing device (HemotypeSC)™ for diagnosing sickle cell disease (SCD) relative to 2 commonly-used methods compared to DNA polymerase chain reaction (PCR) as the reference standard. The diagnostic performance of (HemotypeSC)™ in diagnosing SCD and determining various other Hb genotypes relative to high performance liquid chromatography (HPLC) and cellulose acetate Hb electrophoresis in alkaline buffer (CAE) was investigated among 156 participants aged 4 to 23 years in Ekiti, Southwest Nigeria. PCR was considered as the reference method/gold standard. The sensitivity and specificity for SS, SC, AS, AC, and AA genotypes by HemotypeSC and HPLC when compared with PCR, were each 100%. Similarly, their positive and negative predictive values were each 100%. However, sensitivity and specificity for identifying these Hb genotypes by CAE were 100, 100, 96.5, 0, 99.2%, and 99, 100, 92.9, 0, 91.7%. Also, CAE did not identify any of the 2 HbAC individuals that were correctly identified by PCR and both HemotypeSC, and HPLC, thus representing 100% HbAC misdiagnosis. In conclusion, this study shows that HemotypeSC has perfect concordance with PCR and 100% accuracy in diagnosing SCD in the population tested. Its ease of use, accuracy and other attributes make it suitable for use in sub-Saharan Africa for rapid determination of Hb genotypes.

Communicating sickle cell disease point-of-care testing results

2020 ◽  
Vol 7 (10) ◽  
pp. e708-e709
Author(s):  
Cheedy Jaja ◽  
Robert W Gibson ◽  
Joseph Edem-Hotah
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Point Of Care ◽  
Cell Disease ◽  
Point Of Care Testing

scholarly journals HemoTypeSC, a low-cost point-of-care testing device for sickle cell disease: Promises and challenges

2019 ◽  
Vol 78 ◽  
pp. 22-28 ◽  
Author(s):  
Obiageli Nnodu ◽  
Hezekiah Isa ◽  
Maxwell Nwegbu ◽  
Chinatu Ohiaeri ◽  
Samuel Adegoke ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Point Of Care ◽  
Low Cost ◽  
Testing Device ◽  
Cell Disease ◽  
Point Of Care Testing

scholarly journals Antiphospholipid Antibodies in Sickle Cell Disease: A Systematic Review and Exploratory Meta-Analysis

2021 ◽  
Vol 27 ◽  
pp. 107602962110029
Author(s):  
Mira Merashli ◽  
Alessia Arcaro ◽  
Maria Graf ◽  
Matilde Caruso ◽  
Paul R. J. Ames ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Antiphospholipid Antibodies ◽  
Meta Analysis ◽  
Age Groups ◽  
Anticardiolipin Antibodies ◽  
Cell Disease ◽  
Pooled Prevalence ◽  
The Relationship

The relationship between antiphospholipid antibodies (aPL) and sickle cell disease (SCD) has never been systematically addressed. Our aim was to evaluate potential links between SCD and aPL in all age groups. EMBASE/PubMed was screened from inception to May 2020 and Peto odds ratios for rare events were calculated. The pooled prevalence (PP) of IgG anticardiolipin antibodies (aCL) was higher in individuals with SCD than in controls (27.9% vs 8.7%, P < 0.0001), that of IgM aCL was similar in the two groups (2.9% vs 2.7%); only individuals with SCD were positive for lupus anticoagulant (LA) (7.7% vs 0%, P < 0.0001). The PP of leg ulcers was similar between aPL positive and negative individuals (44% vs 53%) and between patients in acute crisis and stable patients (5.6% vs 7.3%). Reporting of aPL as a binary outcome and not as a titer precluded further interpretation. The results indicate that a prospective case-control study with serial measurements of a panel of aPL in SCD patients might be warranted, in order to understand further the possible pathogenic role of aPL in SCD.

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