scholarly journals Immature platelets in COVID‐19 infection

2021 ◽  
Author(s):  
Robert W. Maitta
Keyword(s):  
Immature Platelets

scholarly journals Immature platelets as a biomarker for disease severity and mortality in COVID‐19 patients

2021 ◽  
Author(s):  
Daniel Welder ◽  
Haekyung Jeon‐Slaughter ◽  
Bilal Ashraf ◽  
Sung‐Hee Choi ◽  
Weina Chen ◽  
...  
Keyword(s):  
Disease Severity ◽  
Immature Platelets

Immature platelet values indicate impaired megakaryopoietic activity in neonatal early-onset thrombocytopenia

2010 ◽  
Vol 103 (05) ◽  
pp. 1016-1021 ◽  
Author(s):  
Hannes Hammer ◽  
Christoph Bührer ◽  
Christof Dame ◽  
Malte Cremer ◽  
Andreas Weimann
Keyword(s):  
Bone Marrow ◽  
Flow Cytometry ◽  
Intensive Care ◽  
Early Onset ◽  
Absolute Number ◽  
Severe Thrombocytopenia ◽  
Platelet Counts ◽  
Immature Platelet Fraction ◽  
Neonatal Thrombocytopenia ◽  
Immature Platelets

SummaryNewly released platelets, referred to as immature platelets, can be reliably quantified based on their RNA content by flow cytometry in an automated blood analyser. The absolute number of immature platelets (IPF#) and the immature platelet fraction (IPF%) reflect megakaryopoietic activity. We aimed to analyse the implication of these parameters in analysing the pathomechanism of early-onset neonatal thrombocytopenia. Platelet counts and IPF were determined at day 1 to 3 (d1 to d3) in 857 neonates admitted to intensive care. In thrombocytopenic patients (platelet counts<150 x 109/l, n=129), IPF# was significantly lower (8.5 ± 2.7 x 109/l), than in non-thrombocytopenic neonates (9.5 ± 3.6 x 109/l, n=682, p<0.05). IPF% was significantly higher in thrombocytopenic (9.3 ± 7.9%) vs. non-thrombocytopenic neonates (4.1 ± 1.8%, p<0.001). While neonates with early-onset infection (n=134) had lower platelet counts (199 ± 75 x 109/l) compared to controls (230 ± 68 x 109/l, n=574, p<0.01), there were no differences in IPF# or IPF%. Likewise, “small for gestational age” infants (SGA, n=149) had lower platelet counts at d1 (199 ± 75 x 109/l, p<0.001) than controls, but no differences in IPF. A trend towards lower IPF# was detected if SGA infants with platelet counts <100 x 109/l (5.4 ± 3.9 x 109/l, n=11) and thrombocytopenic neonates with infection (9.9 ± 7.3 x 109/l, n=10, p=0.11) were compared. The evaluation of IPF# indicates that thrombocytopenia in neonates is likely due to a combination of increased platelet consumption and inadequate megakaryopoietic response by the neonatal bone marrow. Furthermore, SGA neonates with moderate and severe thrombocytopenia might have a pronounced suppression of megakaryopoiesis compared to neonates with infection.

Immature Platelets and Risk of Cardiovascular Events among Patients with Ischemic Heart Disease: A Systematic Review

2020 ◽  
Author(s):  
Julie Faber ◽  
Anne-Mette Hvas ◽  
Steen Dalby Kristensen ◽  
Erik Lerkevang Grove ◽  
Kasper Adelborg
Keyword(s):  
Systematic Review ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Cardiovascular Events ◽  
Ischemic Heart ◽  
Cochrane Library ◽  
Coronary Syndrome ◽  
Immature Platelet Fraction ◽  
Immature Platelets ◽  
Stable Cad

Abstract Background Immature platelets are larger and may be more thrombogenic than mature platelets. This systematic review included studies on the association between mean platelet volume (MPV), immature platelet count (IPC), and immature platelet fraction (IPF) and the risk of major cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) or stable coronary artery disease (CAD). Methods The literature search included studies in PubMed, Embase, Web of Science, and Cochrane Library. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. Effect estimates that included multivariate adjusted odds ratios, relative risks, or hazard ratios were extracted. Results Forty-two studies were identified. High MPV was positively associated with MACE in 20 of 26 studies of patients with ACS, four of five studies in patients with stable CAD, and in all six studies comprising a combined population with ACS and stable CAD. Using continuous models of MPV in patients with ACS, effect estimates varied from 0.90 (95% confidence interval [CI]: 0.95–1.03) to 1.66 (95% CI: 1.32–2.09). The strength of these associations was broadly similar among patients with stable CAD and in combined populations. Five studies investigated IPC or IPF as exposures and all reported positive associations with MACE among patients with ACS, stable CAD, or in combined populations. Conclusion This review demonstrated clear evidence for positive associations between measures of immature platelets and subsequent risk of MACE in acute and stable ischemic heart disease patients.

Immature platelets: a review of the available evidence

2020 ◽  
Vol 195 ◽  
pp. 43-50
Author(s):  
Naoufal Benlachgar ◽  
Kamal Doghmi ◽  
Azlarab Masrar ◽  
El Mehdi Mahtat ◽  
Hicham Harmouche ◽  
...  
Keyword(s):  
Immature Platelets

scholarly journals Mature and immature platelets during the first week after birth and incidence of patent ductus arteriosus

2020 ◽  
Vol 30 (6) ◽  
pp. 769-773 ◽  
Author(s):  
Hannes Sallmon ◽  
Boris Metze ◽  
Petra Koehne ◽  
Bernd Opgen-Rhein ◽  
Katja Weiss ◽  
...  
Keyword(s):  
Platelet Count ◽  
Birth Weight ◽  
Patent Ductus Arteriosus ◽  
Very Low Birth Weight ◽  
Ductus Arteriosus ◽  
Postnatal Life ◽  
Platelet Counts ◽  
Immature Platelet Fraction ◽  
Immature Platelets ◽  
Patent Ductus

AbstractBackground:Thrombocytopenia is a risk factor for patent ductus arteriosus. Immature and mature platelets exhibit distinct haemostatic properties; however, whether platelet maturity plays a role in postnatal, ductus arteriosus closure is unknown.Methods:In this observational study, counts of immature and mature platelets (=total platelet count − immature platelet count) were assessed on days 1, 3, and 7 of life in very low birth weight infants (<1500 g birth weight). We performed echocardiographic screening for haemodynamically significant patent ductus arteriosus on day 7.Results:Counts of mature platelets did not differ on day 1 in infants with (n = 24) and without (n = 45) haemodynamically significant patent ductus arteriosus, while infants with significant patent ductus arteriosus exhibited lower counts of mature platelet on postnatal days 3 and 7. Relative counts of immature platelets (fraction, in %) were higher in infants with patent ductus arteriosus on day 7 but not on days 1 and 3. Receiver operating characteristic curve analysis unraveled associations between both lower mature platelet counts and higher immature platelet fraction (percentage) values on days 3 and 7, with haemodynamically significant ductus arteriosus. Logistic regression analysis revealed that mature platelet counts, but not immature platelet fraction values, were independent predictors of haemodynamically significant patent ductus arteriosus.Conclusion:During the first week of postnatal life, lower counts of mature platelets and higher immature platelet fraction values are associated with haemodynamically significant patent ductus arteriosus. Lower counts of mature platelet were found to be independent predictors of haemodynamically significant patent ductus arteriosus.

Impact of diabetes on immature platelets fraction and its relationship with platelet reactivity in patients receiving dual antiplatelet therapy

2016 ◽  
Vol 42 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Monica Verdoia ◽  
Patrizia Pergolini ◽  
Matteo Nardin ◽  
Roberta Rolla ◽  
Lucia Barbieri ◽  
...  
Keyword(s):  
Antiplatelet Therapy ◽  
Dual Antiplatelet Therapy ◽  
Platelet Reactivity ◽  
Immature Platelets

scholarly journals P6042Establishing Syto 13 as an alternative dye for the cytometric evaluation of RNA-rich immature platelets

2017 ◽  
Vol 38 (suppl_1) ◽  
Author(s):  
M. Cederqvist ◽  
C. Stratz ◽  
T. Nuhrenberg ◽  
L. Hille ◽  
F.-J. Neumann ◽  
...  
Keyword(s):  
Immature Platelets ◽  
Syto 13
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