The vasculopathic cord between pre‐eclampsia and kidney function in sickle cell disease

2021 ◽  
Author(s):  
Santosh L. Saraf
Keyword(s):  
Sickle Cell Disease ◽  
Kidney Function ◽  
Sickle Cell ◽  
Cell Disease

Erythropoietin Levels in Patients with Sickle Cell Disease Not in Vaso-Occlusive Crisis

Blood ◽  
2012 ◽  
Vol 120 (21) ◽  
pp. 3242-3242
Author(s):  
Dianne Pulte ◽  
Srikanth Nagalla ◽  
Jaime Caro
Keyword(s):  
Sickle Cell Disease ◽  
Kidney Function ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Hemoglobin Level ◽  
Laboratory Evaluation ◽  
Cell Disease ◽  
Chronic Anemia ◽  
Number Of Patients ◽  
Erythropoietin Level

Abstract Abstract 3242 Background: Previous studies of erythropoietin production in sickle cell disease have shown that patients with sickle cell disease generally have an erythropoietin level in the lower end of the expected range. However, this finding was based on a relatively small number of patients including some who were in crisis when the erythropoietin level was drawn. A crisis might affect erythropoietin level by increasing inflammation beyond background and if the patient is transfused, the erythropoietin may not be well correlated with the apparent hemoglobin or hematocrit. In this study, we examine erythropoietin levels in patients with sickle cell disease seen in the outpatient clinic and not in crisis when the level was drawn. Methods: Patients receiving outpatient care at the Thomas Jefferson University Cardeza Sickle Center underwent laboratory evaluation as part of routine standard of care for their disease. Hemoglobin level, creatinine, erythropoietin level, lactate dehydrogenase, and reticulocyte count were extracted anonymously from patient charts for evaluation of erythropoietin in sickle patients in the outpatient setting without crisis and correlation of level with kidney function, hemoglobin level, and ongoing hemolysis. Results: Forty-eight measurements of erythropoietin from 39 unique patients were extracted. Two were not included as chart review suggested that the patient was in crisis when the values were obtained. Of the remaining 36 patients, three patients had SC disease, four sickle-thalassemia, the rest sickle cell anemia. Three patients received exogenous erythropoietin for hypoplastic anemia or chronic renal failure complicating sickle cell disease. Of the remaining 30 patients, creatinine ranged from 0.2–1.8. Erythropoietin was higher than the normal range for most patients, as would be expected in a chronic anemia. Erythropoietin level was roughly correlated with hemoglobin, but some patients had erythropoietin levels much lower than expected for their hemoglobin (figure). Erythropoietin was not well correlated with creatinine or with hemolysis. Hemoglobin was higher for patients with SC disease than for sickle cell anemia or sickle-thalassemia, but erythropoietin levels were not significantly different between disease types. Conclusions: Patients with sickle cell disease who are not in crisis have erythropoietin levels that are elevated, but lower than expected for a healthy patient with chronic anemia, with a greater lack in patients with sickle cell anemia as compared to SC disease. Erythropoietin did not correlate well with kidney function as measured by creatinine or calculated glomerular filtration rate, suggesting that current measures of kidney damage may not be entirely adequate to detect early kidney disease in sickle cell disease. Disclosures: No relevant conflicts of interest to declare.

scholarly journals The prevalence of hypertension and abnormal kidney function in children with sickle cell disease –a cross sectional review

2013 ◽  
Vol 14 (1) ◽  
Author(s):  
Prasad Bodas ◽  
Alex Huang ◽  
Mary Ann O’Riordan ◽  
John R Sedor ◽  
Katherine MacRae Dell
Keyword(s):  
Sickle Cell Disease ◽  
Kidney Function ◽  
Sickle Cell ◽  
Cell Disease ◽  
Cross Sectional

scholarly journals Kidney function, urinalysis abnormalities and correlates in equatorial Africans with sickle cell disease

2012 ◽  
Vol 6 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Francois Folefack Kaze ◽  
Andre-Pascal Kengne ◽  
Leonel Christophe Atanga ◽  
Marcel Monny Lobe ◽  
Alain Patrick Menanga ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Kidney Function ◽  
Sickle Cell ◽  
Cell Disease

scholarly journals Kidney Function Decline among Black Patients with Sickle Cell Trait and Sickle Cell Disease: An Observational Cohort Study

2019 ◽  
Vol 31 (2) ◽  
pp. 393-404 ◽  
Author(s):  
Kabir O. Olaniran ◽  
Andrew S. Allegretti ◽  
Sophia H. Zhao ◽  
Maureen M. Achebe ◽  
Nwamaka D. Eneanya ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Kidney Function ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Cell Disease ◽  
Hemoglobin S ◽  
Black Patients ◽  
Kidney Function Decline ◽  
Egfr Decline

BackgroundSickle cell trait and sickle cell disease are thought to be independent risk factors for CKD, but the trajectory and predictors of kidney function decline in patients with these phenotypes are not well understood.MethodsOur multicenter, observational study used registry data (collected January 2005 through June 2018) and included adult black patients with sickle cell trait or disease (exposures) or normal hemoglobin phenotype (reference) status (ascertained by electrophoresis) and at least 1 year of follow-up and three eGFR values. We used linear mixed models to evaluate the difference in the mean change in eGFR per year.ResultsWe identified 1251 patients with sickle cell trait, 230 with sickle cell disease, and 8729 reference patients, with a median follow-up of 8 years. After adjustment, eGFR declined significantly faster in patients with sickle cell trait or sickle cell disease compared with reference patients; it also declined significantly faster in patients with sickle cell disease than in patients with sickle cell trait. Male sex, diabetes mellitus, and baseline eGFR ≥90 ml/min per 1.73 m2 were associated with faster eGFR decline for both phenotypes. In sickle cell trait, low hemoglobin S and elevated hemoglobin A were associated with faster eGFR decline, but elevated hemoglobins F and A2 were renoprotective.ConclusionsSickle cell trait and disease are associated with faster eGFR decline in black patients, with faster decline in sickle cell disease. Low hemoglobin S was associated with faster eGFR decline in sickle cell trait but may be confounded by concurrent hemoglobinopathies. Prospective and mechanistic studies are needed to develop best practices to attenuate eGFR decline in such patients.

scholarly journals Effects of renin‐angiotensin blockade and APOL1 on kidney function in sickle cell disease

eJHaem ◽  
2021 ◽  
Author(s):  
Jin Han ◽  
Andrew Srisuwananukorn ◽  
Binal N. Shah ◽  
Robert E. Molokie ◽  
James P. Lash ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Kidney Function ◽  
Sickle Cell ◽  
Cell Disease ◽  
Renin Angiotensin ◽  
Angiotensin Blockade

Hemolysis in sickle cell disease

1974 ◽  
Vol 133 (4) ◽  
pp. 624-631 ◽  
Author(s):  
T. A. Bensinger
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease
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