Detection mode of childhood acute lymphoblastic leukaemia relapse and its effect on survival: a Nordic population‐based cohort study

2021 ◽  
Author(s):  
Karen S. Jensen ◽  
Trausti Oskarsson ◽  
Päivi M. Lähteenmäki ◽  
Trond Flaegstad ◽  
Kjeld Schmiegelow ◽  
...  
Keyword(s):  
Cohort Study ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Population Based ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Detection Mode ◽  
Leukaemia Relapse

scholarly journals National, clinical cohort study of late effects among survivors of acute lymphoblastic leukaemia: the ALL-STAR study protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e045543
Author(s):  
Liv Andrés-Jensen ◽  
Mette Tiedemann Skipper ◽  
Kristian Mielke Christensen ◽  
Pia Hedegaard Johnsen ◽  
Katrine Aagaard Myhr ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Dental Health ◽  
Population Based ◽  
Psychosocial Treatment ◽  
Self Report ◽  
Metabolic Disturbances ◽  
Childhood All

IntroductionMore than 90% of patients diagnosed with childhood acute lymphoblastic leukaemia (ALL) today will survive. However, half of the survivors are expected to experience therapy-related chronic or late occurring adverse effects, reducing quality of life. Insight into underlying risk trajectories is warranted. The aim of this study is to establish a Nordic, national childhood ALL survivor cohort, to be investigated for the total somatic and psychosocial treatment-related burden as well as associated risk factors, allowing subsequent linkage to nation-wide public health registers.Methods and analysisThis population-based observational cohort study includes clinical follow-up of a retrospective childhood ALL survivor cohort (n=475), treated according to a common Nordic ALL protocol during 2008–2018 in Denmark. The study includes matched controls. Primary endpoints are the cumulative incidence and cumulative burden of 197 health conditions, assessed through self-report and proxy-report questionnaires, medical chart validation, and clinical examinations. Secondary endpoints include organ-specific outcome, including cardiovascular and pulmonary function, physical performance, neuropathy, metabolic disturbances, hepatic and pancreatic function, bone health, oral and dental health, kidney function, puberty and fertility, fatigue, and psychosocial outcome. Therapy exposure, acute toxicities, and host genome variants are explored as risk factors.Ethics and disseminationThe study is approved by the Regional Ethics Committee for the Capital Region in Denmark (H-18035090/H-20006359) and by the Danish Data Protection Agency (VD-2018–519). Results will be published in peer-reviewed journals and are expected to guide interventions that will ameliorate the burden of therapy without compromising the chance of cure.

scholarly journals Childhood acute lymphoblastic leukaemia relapse with atypical localised presentation mimicking ankle trauma in a 28-year-old man

2019 ◽  
Vol 12 (5) ◽  
pp. e228541
Author(s):  
Charlie Weige Zhao ◽  
Vinit Singh ◽  
Vasundhara Singh
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Paediatric Cancer ◽  
Ankle Pain ◽  
Childhood All ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Ankle Trauma ◽  
High Index Of Suspicion ◽  
Leukaemia Relapse

Acute lymphoblastic leukaemia (ALL) is a common paediatric cancer with a tendency to relapse, usually within 3 years of remission. Most patients present with hepatomegaly, splenomegaly, pallor, fever and bruising. Localised muskuloskeletal presentation is extremely rare. Here, we present a case of leukaemia relapse in the bone marrow of a 28-year-old man 9 years after achieving remission, presenting only with ankle pain and normal routine labs besides mild hypercalcemia, and no signs of disease in common bone marrow biopsy sites. This highly localised presentation is unusual and would hopefully inform clinicians to have a high index of suspicion for relapse in an adult patient who has had childhood ALL.

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