scholarly journals Point‐of‐care haemoglobin testing in African hospitals: a neglected essential diagnostic test

2021 ◽  
Author(s):  
Sophie Uyoga ◽  
Elizabeth C. George ◽  
Imelda Bates ◽  
Peter Olupot‐Olupot ◽  
Yami Chimalizeni ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Point Of Care ◽  
Haemoglobin Testing

scholarly journals The diagnostic accuracy of isothermal nucleic acid point-of-care tests for human coronaviruses: A systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Pakpoom Subsoontorn ◽  
Manupat Lohitnavy ◽  
Chuenjid Kongkaew
Keyword(s):  
Systematic Review ◽  
Diagnostic Accuracy ◽  
Diagnostic Test ◽  
Point Of Care ◽  
Meta Analysis ◽  
Isothermal Amplification ◽  
Diagnostic Test Accuracy ◽  
Test Accuracy ◽  
Index Test ◽  
Point Of Care Tests

AbstractMany recent studies reported coronavirus point-of-care tests (POCTs) based on isothermal amplification. However, the performances of these tests have not been systematically evaluated. Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy was used as a guideline for conducting this systematic review. We searched peer-reviewed and preprint articles in PubMed, BioRxiv and MedRxiv up to 28 September 2020 to identify studies that provide data to calculate sensitivity, specificity and diagnostic odds ratio (DOR). Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was applied for assessing quality of included studies and Preferred Reporting Items for a Systematic Review and Meta-analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA) was followed for reporting. We included 81 studies from 65 research articles on POCTs of SARS, MERS and COVID-19. Most studies had high risk of patient selection and index test bias but low risk in other domains. Diagnostic specificities were high (> 0.95) for included studies while sensitivities varied depending on type of assays and sample used. Most studies (n = 51) used reverse transcription loop-mediated isothermal amplification (RT-LAMP) to diagnose coronaviruses. RT-LAMP of RNA purified from COVID-19 patient samples had pooled sensitivity at 0.94 (95% CI: 0.90–0.96). RT-LAMP of crude samples had substantially lower sensitivity at 0.78 (95% CI: 0.65–0.87). Abbott ID Now performance was similar to RT-LAMP of crude samples. Diagnostic performances by CRISPR and RT-LAMP on purified RNA were similar. Other diagnostic platforms including RT- recombinase assisted amplification (RT-RAA) and SAMBA-II also offered high sensitivity (> 0.95). Future studies should focus on the use of un-bias patient cohorts, double-blinded index test and detection assays that do not require RNA extraction.

scholarly journals Innovative point-of-care molecular diagnostic test for COVID-19 in India

2020 ◽  
Vol 1 (7) ◽  
pp. e277
Author(s):  
Nivedita Gupta ◽  
Salaj Rana ◽  
Harpreet Singh
Keyword(s):  
Diagnostic Test ◽  
Point Of Care ◽  
Molecular Diagnostic ◽  
Molecular Diagnostic Test

scholarly journals Closing the loop on test results to reduce communication failures: a rapid review of evidence, practice and patient perspectives

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Breanna Wright ◽  
Alyse Lennox ◽  
Mark L. Graber ◽  
Peter Bragge
Keyword(s):  
Diagnostic Test ◽  
Point Of Care ◽  
Patient Perspectives ◽  
Audit And Feedback ◽  
Rapid Review ◽  
Test Results ◽  
Multiple Perspectives ◽  
Communication Breakdown ◽  
Closing The Loop ◽  
Test Result

Abstract Background Communication failures involving test results contribute to issues of patient harm and sentinel events. This article aims to synthesise review evidence, practice insights and patient perspectives addressing problems encountered in the communication of diagnostic test results. Methods The rapid review identified ten systematic reviews and four narrative reviews. Five practitioner interviews identified insights into interventions and implementation, and a citizen panel with 15 participants explored the patient viewpoint. Results The rapid review provided support for the role of technology to ensure effective communication; behavioural interventions such as audit and feedback could be effective in changing clinician behaviour; and point-of-care tests (bedside testing) eliminate the communication breakdown problem altogether. The practice interviews highlighted transparency, and clarifying the lines of responsibility as central to improving test result communication. Enabling better information sharing, implementing adequate planning and utilising technology were also identified in the practice interviews as viable strategies to improve test result communication. The citizen panel highlighted technology as critical to improving communication of test results to both health professionals and patients. Patients also highlighted the importance of having different ways of accessing test results, which is particularly pertinent when ensuring suitability for vulnerable populations. Conclusions This paper draws together multiple perspectives on the problem of failures in diagnostic test results communication to inform appropriate interventions. Across the three studies, technology was identified as the most feasible option for closing the loop on test result communication. However, the importance of clear, consistent communication and more streamlined processes were also key elements that emerged. Review registration The protocol for the rapid review was registered with PROSPERO CRD42018093316.

My Patient is Short of Breath: Have They Got a Pneumothorax?

Ultrasound ◽  
2011 ◽  
Vol 19 (4) ◽  
pp. 230-235 ◽  
Author(s):  
David Lewis
Keyword(s):  
Emergency Department ◽  
Critical Care ◽  
Diagnostic Test ◽  
Chest Radiograph ◽  
Chest Radiography ◽  
Care Setting ◽  
Imaging Modality ◽  
Point Of Care ◽  
First Line ◽  
Resuscitation Room

Clinical diagnosis of pneumothorax in the emergency department (ED) resuscitation room can be difficult and in certain circumstances chest radiography is either impractical or the delay is unacceptable. The diagnosis must also be considered in other clinical areas such as critical care, theatres, respiratory units and acute medical units. Erect chest radiography is the standard first-line diagnostic test for pneumothorax in the ED, but the sensitivity is low (59–81%). For many patients in ED, critical care and theatre, an erect chest radiograph is not possible as the patient must remain supine. The sensitivity for a supine chest radiograph has been reported as being 45–75%. Ultrasound has been shown to be more sensitive than chest radiography in the diagnosis of pneumothorax in certain settings. This paper outlines the evidence for ultrasound in the diagnosis of pneumothorax in the point of care setting; it describes the technique and discusses the clinical application of this imaging modality.

scholarly journals Diagnostic test accuracy of point-of-care procalcitonin to diagnose serious bacterial infections in children

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Thomas Waterfield ◽  
◽  
Julie-Ann Maney ◽  
Mark D Lyttle ◽  
James P McKenna ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Bacterial Infections ◽  
Point Of Care ◽  
Area Under The Curve ◽  
Final Analysis ◽  
Diagnostic Test Accuracy ◽  
Trial Registration ◽  
Test Accuracy ◽  
Reactive Protein ◽  
Serious Bacterial Infections

Abstract Background The National Institute for Health and Care Excellence (NICE) have called for research into the role of biomarkers, and specifically procalcitonin (PCT), for the early diagnosis of serious bacterial infections (SBI) in children. The aim of this study was to compare the diagnostic test accuracy of C-reactive protein (CRP) and PCT for the diagnosis of SBI in children. Methods Data was collected prospectively from four UK emergency departments (ED) between November 2017 and June 2019. Consecutive children under 18 years of age with fever and features of possible sepsis and/or meningitis were eligible for inclusion. The index tests were PCT and CRP and the reference standard was the confirmation of SBI. Results 213 children were included in the final analysis. 116 participants (54.5%) were male, and the median age was 2 years, 9 months. Parenteral antibiotics were given to 100 (46.9%), three (1.4%) were admitted to a paediatric intensive care unit and there were no deaths. There were ten (4.7%) confirmed SBI. The area under the curve for PCT and CRP for the detection of SBI was identical at 0.70. Conclusions There was no difference in the performance of PCT and CRP for the recognition of SBI in this cohort. Trial registration Registered at https://www.clinicaltrials.gov (trial registration: NCT03378258) on the 19th of December 2017.

Isothermal Recombinase Polymerase Amplification-Lateral Flow Point-of-Care Diagnostic Test for Heartland Virus

2020 ◽  
Author(s):  
Thomas R. Shelite ◽  
Nathen E. Bopp ◽  
Abelardo Moncayo ◽  
Erin S. Reynolds ◽  
Saravanan Thangamani ◽  
...  
Keyword(s):  
Diagnostic Test ◽  
Point Of Care ◽  
Lateral Flow ◽  
Recombinase Polymerase Amplification

scholarly journals Rapid Point-of-Care Diagnostic Test for Syphilis in High-Risk Populations, Manaus, Brazil

2009 ◽  
Vol 15 (4) ◽  
pp. 647-649 ◽  
Author(s):  
Meritxell Sabidó ◽  
Adele S. Benzaken ◽  
Ệnio José de Andrade Rodrigues ◽  
Philippe Mayaud
Keyword(s):  
High Risk ◽  
Diagnostic Test ◽  
Point Of Care ◽  
High Risk Populations
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