scholarly journals Non‐myeloablative human leukocyte antigen‐matched related donor transplantation in sickle cell disease: outcomes from three independent centres

2021 ◽  
Vol 192 (4) ◽  
pp. 761-768
Author(s):  
Mohsen Alzahrani ◽  
Moussab Damlaj ◽  
Neal Jeffries ◽  
Bader Alahmari ◽  
Avani Singh ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Human Leukocyte Antigen ◽  
Sickle Cell ◽  
Human Leukocyte ◽  
Cell Disease ◽  
Leukocyte Antigen ◽  
Disease Outcomes ◽  
Related Donor

Human leukocyte antigen distribution and genomic ancestry in Brazilian patients with sickle cell disease

HLA ◽  
2017 ◽  
Vol 90 (4) ◽  
pp. 211-218 ◽  
Author(s):  
M. C. F. da Silva-Malta ◽  
P. S. Rodrigues ◽  
L. W. Zuccherato ◽  
F. C. B. de Souza ◽  
E. M. F. L. Domingues ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Human Leukocyte Antigen ◽  
Sickle Cell ◽  
Human Leukocyte ◽  
Cell Disease ◽  
Leukocyte Antigen

scholarly journals Related Donor Human Leukocyte Antigen Typing: Developing a Process for Utilization of Buccal Swabs Versus Blood Tubes

2016 ◽  
Vol 22 (3) ◽  
pp. S457-S458
Author(s):  
Kim Schmit-Pokorny ◽  
Cathy Gebhart ◽  
Sophia Hauxwell ◽  
Jeanine Schademann ◽  
JoAnn Tate
Keyword(s):  
Human Leukocyte Antigen ◽  
Human Leukocyte ◽  
Human Leukocyte Antigen Typing ◽  
Leukocyte Antigen ◽  
Buccal Swabs ◽  
Related Donor

scholarly journals Matched-related donor transplantation for sickle cell disease: report from the Center for International Blood and Transplant Research

2007 ◽  
Vol 137 (5) ◽  
pp. 479-485 ◽  
Author(s):  
Julie A. Panepinto ◽  
Mark C. Walters ◽  
Jeanette Carreras ◽  
Judith Marsh ◽  
Christopher N. Bredeson ◽  
...  
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Related Donor

scholarly journals Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes

2007 ◽  
Vol 83 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Laura M. De Castro ◽  
Jude C. Jonassaint ◽  
Felicia L. Graham ◽  
Allison Ashley-Koch ◽  
Marilyn J. Telen
Keyword(s):  
Pulmonary Hypertension ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Disease Outcomes

scholarly journals Evidence-Based Minireview: In young children with severe sickle cell disease, do the benefits of HLA-identical sibling donor HCT outweigh the risks?

Hematology ◽  
2021 ◽  
Vol 2021 (1) ◽  
pp. 190-195
Author(s):  
Niketa Shah ◽  
Lakshmanan Krishnamurti
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Medical Condition ◽  
Human Leukocyte ◽  
Female Child ◽  
Cell Transplant ◽  
Cell Disease ◽  
Hematopoietic Stem ◽  
Febrile Episodes ◽  
First Year Of Life

Abstract In case 1, a 14-month-old male child with sickle cell disease (SCD) was referred for evaluation for an allogeneic hematopoietic stem cell transplant (HCT). The patient had a history of dactylitis 3 times in his first year of life and febrile episodes twice at the consult. His 4-year-old sister was found to be human leukocyte antigen (HLA) identical. The patient was started on hydroxyurea (HU) at 2.5 years of age. His parents again sought consultation when he was 5 years old because of concerns about his medical condition. At the time, the patient had experienced 2 vaso-occlusive pain episodes (VOEs) requiring hospitalization during the previous 2 years. He had also experienced intermittent pain crises requiring rest at home for 2 to 3 days. The child has not attended school in person due to the COVID-19 pandemic. The family is considering HCT but is ambivalent about it because of potential toxicity. In case 2, an 8-year-old female child is 3 years out from HCT for SCD from her HLA-identical sibling. Before HCT, despite receiving HU, she had experienced >5 VOEs requiring hospitalization and 2 episodes of acute chest syndromes in the previous 3 years. She had also been missing almost 50 days of school days each year. After HCT, she is now attending school regularly and participating in all normal age-appropriate activities. The parents believe that HCT has been transformative in their child's life.

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