Prognostic value of minimal residual disease measured by fusion‐gene transcript in infants with KMT2A ‐rearranged acute lymphoblastic leukaemia treated according to the MLL‐Baby protocol

2021 ◽  
Author(s):  
Grigory Tsaur ◽  
Alexander Popov ◽  
Tatiana Riger ◽  
Anatoly Kustanovich ◽  
Alexander Solodovnikov ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Prognostic Value ◽  
Residual Disease ◽  
Fusion Gene ◽  
Gene Transcript ◽  
Minimal Residual

Prognostic value of minimal residual disease in relapsed childhood acute lymphoblastic leukaemia

The Lancet ◽  
2001 ◽  
Vol 358 (9289) ◽  
pp. 1239-1241 ◽  
Author(s):  
Cornelia Eckert ◽  
Andrea Biondi ◽  
Karlheinz Seeger ◽  
Giovanni Cazzaniga ◽  
Reinhard Hartmann ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Prognostic Value ◽  
Residual Disease ◽  
Childhood Acute Lymphoblastic Leukaemia ◽  
Minimal Residual

Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood

The Lancet ◽  
1998 ◽  
Vol 352 (9142) ◽  
pp. 1731-1738 ◽  
Author(s):  
Jacques JM van Dongen ◽  
Taku Seriu ◽  
E Renate Panzer-Grümayer ◽  
Andrea Biondi ◽  
Marja J Pongers-Willemse ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Prognostic Value ◽  
Residual Disease ◽  
Minimal Residual

Prognostic value of minimal residual disease in acute lymphoblastic leukaemia in childhood

The Lancet ◽  
1999 ◽  
Vol 353 (9154) ◽  
pp. 752 ◽  
Author(s):  
Tomoko Matsumura ◽  
Masahiro Kami ◽  
Toshiki Saito ◽  
Hisashi Sakamaki ◽  
Hisamaru Hirai
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Prognostic Value ◽  
Residual Disease ◽  
Minimal Residual

Flow cytometric minimal residual disease assessment of peripheral blood in acute lymphoblastic leukaemia patients has potential for early detection of relapsed extramedullary disease

2018 ◽  
Vol 71 (7) ◽  
pp. 653-658 ◽  
Author(s):  
Alissa Keegan ◽  
Karry Charest ◽  
Ryan Schmidt ◽  
Debra Briggs ◽  
Daniel J Deangelo ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Peripheral Blood ◽  
Residual Disease ◽  
Diagnostic Value ◽  
Disease Assessment ◽  
Extramedullary Disease ◽  
Systemic Relapse ◽  
Minimal Residual

ObjectivesTo evaluate peripheral blood (PB) for minimal residual disease (MRD) assessment in adults with acute lymphoblastic leukaemia (ALL).MethodsWe analysed 76 matched bone marrow (BM) aspirate and PB specimens independently for the presence of ALL MRD by six-colour flow cytometry (FC).ResultsThe overall rate of BM MRD-positivity was 24% (18/76) and PB was also MRD-positive in 22% (4/18) of BM-positive cases. We identified two cases with evidence of leukaemic cells in PB at the time of the extramedullary relapse that were interpreted as MRD-negative in BM.ConclusionsThe use of PB MRD as a non-invasive method for monitoring of systemic relapse may have added clinical and diagnostic value in patients with high risk of extramedullary disease.

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