Inherited predisposition to haematopoietic malignancies: overcoming barriers and exploring opportunities

2020 ◽  
Author(s):  
Amy M. Trottier ◽  
Lucy A. Godley
Keyword(s):  
Inherited Predisposition

RISKS OF ANEMIA DEVELOPMENT IN DONORS ACCORDING TO INHERITED PREDISPOSITION AND REGULARITY OF BLOOD DONATION

2020 ◽  
pp. 72-83
Author(s):  
I.M. Vorotnikov ◽  
V.A. Razin ◽  
I.M. Lamzin ◽  
M.N. Sokolova ◽  
M.E. Khapman ◽  
...  
Keyword(s):  
Blood Donors ◽  
Blood Donation ◽  
Hla Antigens ◽  
Hla Typing ◽  
Main Role ◽  
Inherited Predisposition ◽  
Group 2 ◽  
Student’S T ◽  
A Prospective Study ◽  
Group 1

Anemia is one of the most common complications of blood donation. Thus, the objective of the paper was to assess the risks of anemia development in donors according to the regularity of donation and inherited predisposition. Materials and Methods. The authors carried out a prospective study, which included 241 blood donors, using random sampling and case-control techniques. Depending on blood donation frequency, the donors were divided into 2 groups: Group 1 consisted of 122 people (51.5 %) frequently donating blood; Group 2 included 119 people (48. 5 %) rarely donating blood. We studied the initial indicators of a general blood test and the same indicators a year after the first blood donation. Additionally, we performed HLA typing of donors. Statistica v. 8.0 software package (Stat Soft Inc., USA) was used for statistical analysis. To compare two independent samples, we used a nonparametric Mann-Whitney U-test and a parametric Student’s t-test (depending on the type of distribution). To assess anemia risks, the odds ratio was calculated. Results. One year after the first blood donation, anemia was diagnosed in 13 people (10.6 %) in Group 1 and in 7 people (5.9 %) in Group 2 (p=0.179). A11 and B7 HLA antigens did not increase anemia risks in group 1 (OS=1.257 (95 % CI 0.318–4.973) and OS=0.240 (95 % CI 0.051–1.134, respectively). HLA-antigens A11 and B7 did not increase anemia risks in Group 1 (OR=1.257 (95 % CI 0.318-4.973) and OR=0.240 (95 % CI 0.051–1.134), respectively). In group 2, antigen-A11 was also an insignificant factor (OS=2.902 (95 % CI 0.606-13.889)) for anemia development. Whereas, antigen-B7 increased anemia risks by 14 times (OS=14.364 (95 % CI 1.644-124.011)). Conclusion. In rare blood donors, it is the genetic factor that plays the main role in anemia development. High prevalence rates of anemia in frequent blood donors are probably determined by other factors. Keywords: anemia, blood donors, HLA typing. Механизмы развития анемий и факторы, их индуцирующие, остаются до конца не изученными. Целью исследования стало изучение риска развития анемии у доноров крови в зависимости от частоты донации и наличия наследственной предрасположенности к развитию анемии. Материалы и методы. Проведено проспективное исследование, выполненное методами случайной выборки и «случай-контроль», в которое вошел 241 донор крови. В зависимости от частоты сдачи доноры были поделены на 2 группы: группу 1 составили 122 чел. (51,5 %), часто сдающие кровь; группу 2 – 119 чел. (48,5 %), редко сдающих кровь. Изучались исходные показатели общего анализа крови и через год от начала донации. Дополнительно проводилось HLA-типирование доноров. Статистический анализ осуществлялся с применением программы Statistica v. 8.0 (Stat Soft Inc., США). Для сравнения двух независимых выборок использовался непараметрический U-критерий Манна–Уитни и параметрический t-критерий Стьюдента (в зависимости от типа распределения). Для оценки риска возникновения анемии рассчитывалось отношение шансов. Результаты. Через год с момента первой сдачи крови в группе 1 выявлено 13 чел. (10,6 %) с анемией, в группе 2 – 7 чел. (5,9 %) (р=0,179). Наличие HLA-антигенов А11 и B7 не повышало риск развития анемии в группе 1 (ОШ=1,257 (95 % ДИ 0,318–4,973) и ОШ=0,240 (95 % ДИ 0,051–1,134 соответственно). В группе 2 наличие гена А11 также являлось незначимым фактором (ОШ=2,902 (95 % ДИ 0,606–13,889), присутствие гена В7 в 14 раз повышало риск развития анемии (ОШ=14,364 (95 % ДИ 1,664–124,011). Выводы. Высокий риск развития анемии у редко сдающих кровь доноров обусловливается генетическими факторами. Высокая распространённость анемии у часто сдающих кровь доноров, вероятно, определяется другими факторами. Ключевые слова: анемия, доноры крови, HLA-типирование.

Inherited predisposition to cancer

1990 ◽  
Vol 6 ◽  
pp. 213-218 ◽  
Author(s):  
B.A.J. Ponder
Keyword(s):  
Inherited Predisposition

Inherited predisposition to breast and ovarian cancer in non-Jewish populations in Israel

2017 ◽  
Vol 166 (3) ◽  
pp. 881-885 ◽  
Author(s):  
Jamal Zidan ◽  
Alicia Y. Zhou ◽  
Jeroen van den Akker ◽  
Yael Laitman ◽  
Hagit Schayek ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Breast And Ovarian Cancer ◽  
Inherited Predisposition ◽  
Jewish Populations

Inherited Predisposition of Dogs to Diet-Induced Hypercholesterolemia

1979 ◽  
Vol 109 (10) ◽  
pp. 1715-1719 ◽  
Author(s):  
D. S. Kronfeld ◽  
Kaye Johnson ◽  
Harris Dunlap
Keyword(s):  
Inherited Predisposition

scholarly journals Inherited predisposition to stillbirth: an intergenerational analysis of 26,788 mother-daughter pairs

2019 ◽  
Vol 220 (4) ◽  
pp. 393.e1-393.e7 ◽  
Author(s):  
Andrea M.F. Woolner ◽  
Edwin Amalraj Raja ◽  
Siladitya Bhattacharya ◽  
Peter Danielian ◽  
Sohinee Bhattacharya
Keyword(s):  
Inherited Predisposition

Inherited predisposition to cancer: A historical overview

2004 ◽  
Vol 129C (1) ◽  
pp. 5-22 ◽  
Author(s):  
Henry T. Lynch ◽  
Trudy G. Shaw ◽  
Jane F. Lynch
Keyword(s):  
Historical Overview ◽  
Inherited Predisposition

Hepatocarcinogenesis: A Polygenic Model of Inherited Predisposition to Cancer

1996 ◽  
Vol 82 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Tommaso A. Dragani ◽  
Federico Canzian ◽  
Giacomo Manenti ◽  
Marco A. Pierotti
Keyword(s):  
Genetic Linkage ◽  
Genetic Basis ◽  
Cell Kinetics ◽  
Hepatocellular Cancer ◽  
Strain Differences ◽  
Polygenic Inheritance ◽  
Inherited Predisposition ◽  
Neoplastic Lesions ◽  
C3h Mice ◽  
Resistant Strains

The murine inbred strain C3H provides an experimental model of inherited predisposition to hepatocellular cancer. Hepatocellular neoplastic lesions induced by chemical carcinogens reach a volume 10-100-fold greater in C3H mice than in genetically resistant strains. However, the huge strain differences in tumor size are explained by relatively small differences (10%-30%) in tumor cell kinetics. Genetic linkage experiments in different crosses demonstrated that six unlinked hepatocarcinogen sensitivity ( Hcs) and two hepatocarcinogen resistance ( Hcr) loci determined quantitative variations in susceptibility to hepatocarcinogenesis. Such results provide the genetic basis for the strain variations in susceptibility to hepatocarcinogenesis and demonstrate a new model of polygenic inheritance of predisposition to cancer.

Psychiatric Syndromes Associated with Cerebrovascular Disorders in the African

1958 ◽  
Vol 104 (434) ◽  
pp. 133-143 ◽  
Author(s):  
T. Adeoye Lambo
Keyword(s):  
Environmental Factors ◽  
Cerebrovascular Disorders ◽  
Endogenous Depression ◽  
Personality Factors ◽  
Cerebrovascular Disorder ◽  
Inherited Predisposition ◽  
The Face ◽  
The Subject ◽  
The Relationship

This contribution towards the subject is limited to three of its aspects—namely, the possible aetiological role of inherited predisposition and psychogenic factors (mainly environmental to which the patient is still exposed), the relationship between late endogenous depression and the symptoms of cerebrovascular changes, and prognosis. On the face of it, prognosis of course must ultimately depend on that of the cerebrovascular disorder but apparently hereditary and environmental factors play a more significant role. Inherited predisposition is here assessed in terms of constitutional and personality factors.

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