Clinical features of vitamin B12 deficiency mimicking thrombotic microangiopathy

2020 ◽  
Vol 191 (5) ◽  
pp. 938-941
Author(s):  
Anita G. Koshy ◽  
Jason A. Freed
Keyword(s):  
Vitamin B12 ◽  
Clinical Features ◽  
Thrombotic Microangiopathy ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals Severe Vitamin B12 Deficiency in Pregnancy Mimicking HELLP Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Shravya Govindappagari ◽  
Michelle Nguyen ◽  
Megha Gupta ◽  
Ramy M. Hanna ◽  
Richard M. Burwick
Keyword(s):  
Vitamin B12 ◽  
Pernicious Anemia ◽  
Thrombotic Microangiopathy ◽  
Hellp Syndrome ◽  
Atypical Hemolytic Uremic Syndrome ◽  
Vitamin B12 Deficiency ◽  
Severe Vitamin ◽  
Elevated Liver Enzymes ◽  
B12 Deficiency ◽  
In Pregnancy

Severe vitamin B12 deficiency may present with hematologic abnormalities that mimic thrombotic microangiopathy disorders such as hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. We report a patient diagnosed with severe vitamin B12 deficiency, following termination of pregnancy for suspected preeclampsia and HELLP syndrome at 21 weeks’ gestation. When hemolysis and thrombocytopenia persisted after delivery, testing was performed to rule out other etiologies of thrombotic microangiopathy, including atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, and vitamin B12 deficiency. This work-up revealed undetectable vitamin B12 levels and presence of intrinsic factor antibodies, consistent with pernicious anemia. Parenteral B12 supplementation was initiated, with subsequent improvement in hematologic parameters. Our case emphasizes the importance of screening for B12 deficiency in pregnancy, especially in at-risk women with unexplained anemia or thrombocytopenia. Moreover, providers should consider B12 deficiency and pernicious anemia in the differential diagnosis of pregnancy-associated thrombotic microangiopathy.

Thrombotic Microangiopathy-Like Hemolysis in Vitamin B12 Deficiency-Related Macrocytic Anemia

2018 ◽  
Vol 64 (04/2018) ◽  
Author(s):  
Masayoshi Yamanishi ◽  
Shigeru Koba ◽  
Takaaki Jo ◽  
Tohru Kotera ◽  
Shinsaku Imashuku
Keyword(s):  
Vitamin B12 ◽  
Thrombotic Microangiopathy ◽  
Macrocytic Anemia ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals Life-threatening Pseudo-thrombotic Microangiopathy Caused by Severe Vitamin B12 Deficiency

2021 ◽  
Vol 9 (11) ◽  
pp. 532-534
Author(s):  
Ziad Abuhelwa ◽  
Talal Khan ◽  
Rana Daas ◽  
Sami Ghazaleh ◽  
Ragheb Assaly
Keyword(s):  
Vitamin B12 ◽  
Thrombotic Microangiopathy ◽  
Vitamin B12 Deficiency ◽  
Severe Vitamin ◽  
Life Threatening ◽  
B12 Deficiency

scholarly journals Vitamin B12 deficiency presenting as pseudo-thrombotic microangiopathy: a case report and literature review

2019 ◽  
Vol Volume 11 ◽  
pp. 127-131 ◽  
Author(s):  
Yazan Fahmawi ◽  
Yesica Campos ◽  
Moh'd Khushman ◽  
Omar Alkharabsheh ◽  
Ashish Manne ◽  
...  
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Vitamin B12 ◽  
Thrombotic Microangiopathy ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency

scholarly journals Vitamin B12 deficiency and metabolism-mediated thrombotic microangiopathy (MM-TMA)

2020 ◽  
Vol 59 (1) ◽  
pp. 102717 ◽  
Author(s):  
Waleed Sabry ◽  
Mohamed Elemary ◽  
Thierry Burnouf ◽  
Jerard Seghatchian ◽  
Hadi Goubran
Keyword(s):  
Vitamin B12 ◽  
Thrombotic Microangiopathy ◽  
Vitamin B12 Deficiency ◽  
B12 Deficiency
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