scholarly journals Acute megakaryoblastic leukaemia with t(1;22)(p13·3;q13·1)/ RBM15‐MKL1 in an adult patient following a non‐mediastinal germ cell tumour

2020 ◽  
Vol 190 (6) ◽  
Author(s):  
Yo Saito ◽  
Shinichi Makita ◽  
Shotaro Chinen ◽  
Momoko Kito ◽  
Takahiro Fujino ◽  
...  
Keyword(s):  
Germ Cell ◽  
Adult Patient ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Megakaryoblastic Leukaemia ◽  
Acute Megakaryoblastic Leukaemia

Non-seminomatous germ-cell tumour associated with acute megakaryoblastic leukaemia

2007 ◽  
Vol 9 (5) ◽  
pp. 329-331 ◽  
Author(s):  
D. Dopico Vázquez ◽  
M. I. Gallegos Sancho ◽  
G. Alonso Curbera ◽  
A. Carral Maseda ◽  
M. Quindós Varela ◽  
...  
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Megakaryoblastic Leukaemia ◽  
Acute Megakaryoblastic Leukaemia

scholarly journals Synchronous Development of Acute Megakaryoblastic Leukaemia and Disseminated Melanoma following Treatment of a Germ Cell Tumour: A Case Report

2021 ◽  
pp. 1638-1644
Author(s):  
Veena Gullapalli ◽  
Hannah Hsu ◽  
Vanita Bhargava ◽  
Peter Presgrave
Keyword(s):  
Germ Cell ◽  
Malignant Transformation ◽  
Germ Cell Tumour ◽  
Liver Lesion ◽  
Cell Tumour ◽  
Metastatic Lesions ◽  
Synchronous Development ◽  
Severe Pancytopenia ◽  
Megakaryoblastic Leukaemia ◽  
Acute Megakaryoblastic Leukaemia

Somatic malignant transformation of germ cell tumours is a well-described but poorly understood phenomenon. It is characterized by differentiation of pluripotent teratoma cells into somatic tumour cells. Following malignant transformation, the most common histologies are sarcomas and primitive neuroectodermal tumours; however, other subtypes have been recognized including melanoma, leukaemia, and renal cell carcinoma. We report a case of a 38-year-old male who had recently completed treatment for a mediastinal germ cell tumour with teratomatous components. He presented several months after completion of chemotherapy with metastatic lesions in his spine and liver accompanied with severe pancytopenia. He was subsequently diagnosed with acute megakaryoblastic leukaemia (AMKL), and a biopsy of a liver lesion was consistent with metastatic melanoma. This case illustrates the simultaneous development of 2 rare malignant entities: mediastinal germ cell tumour-associated AMKL and somatic malignant transformation to melanoma. It also highlights the importance of close surveillance to detect these metastatic sequelae and the emerging role of tumour sequencing to establish targetable pathways.

A suprasellar germ cell tumour presenting with cranial diabetes insipidus

2019 ◽  
Author(s):  
Suhaniya Samarasinghe ◽  
Rebecca Scott ◽  
Michael J Seckl ◽  
Mike Gonzalez ◽  
Richard Harvey ◽  
...  
Keyword(s):  
Germ Cell ◽  
Diabetes Insipidus ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
Cranial Diabetes Insipidus

scholarly journals COVD-01. VINBLASTINE MONOTHERAPY INDUCTION FOR LOCALISED CNS GERMINOMA DURING THE COVID-19 PANDEMIC

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii282-iii282
Author(s):  
Rafael Moleron ◽  
Sara Stoneham ◽  
Thankamma Ajithkumar ◽  
Justin Cross ◽  
James Nicholson ◽  
...  
Keyword(s):  
Germ Cell ◽  
Treatment Options ◽  
Single Agent ◽  
Germ Cell Tumour ◽  
Research Priorities ◽  
Tumour Volume ◽  
Cell Tumour ◽  
Low Grade ◽  
Testicular Seminoma

Abstract INTRODUCTION Patients with localised CNS-germinoma have excellent survival. More recently, intensive inpatient chemotherapy (carboPEI=carboplatin/etoposide/ifosfamide in Europe) has been effectively employed to reduce radiotherapy fields and/or dose. Current research priorities focus on reducing treatment burden and long-term sequelae. Of note, outpatient-based single-agent carboplatin chemotherapy is associated with excellent outcomes in metastatic testicular seminoma (an identical pathology) [Alifrangis,EJC,2020]. Recently, successful vinblastine monotherapy was reported in localised CNS-germinoma [Murray,Neurooncol-Adv,2020]. METHODS Due to the COVID-19 pandemic, adapted UK guidelines for germ-cell-tumour management were distributed, including potential non-standard treatment options that would reduce hospital visits/admissions. A 30-year-old patient presented with a 32mmx30mmx35mm diameter solid+multi-cystic localised pineal CNS lesion, consistent radiologically with a germ-cell-tumour with prominent teratoma component. Investigation revealed negative AFP/HCG markers and biopsy-proven pure germinoma. After appropriate consent, the patient commenced 12-week induction with weekly vinblastine monotherapy (low-grade-glioma dosing [Lassaletta,JCO,2016]), with wk6&12 MRI re-assessment prior to definitive radiotherapy. RESULTS Vinblastine was well-tolerated. After initial 4mg/m2 test-dosing (wk1), standard 6mg/m2 was delivered for wk2, but resulted in asymptomatic neutropenia (nadir 0.3x10^9/l) and missed dosing at wk3. Subsequent doses were 4mg/m2, with no further neutropenia. As expected, MRI showed moderate 40% tumour volume reduction by wk12. Surgical resection of the residual presumed teratoma component was undertaken prior to radiotherapy. CONCLUSION Patients with CNS-germinoma have excellent outcomes and reduction of treatment-effects remains a priority. The exquisite chemosensitivity of germinoma, excellent results from monotherapy for metastatic testicular disease, and early promise of vinblastine monotherapy lend itself to further exploration for CNS-germinoma.

scholarly journals Germ cell tumour chemotherapy

1989 ◽  
Vol 59 (2) ◽  
pp. 156-159 ◽  
Author(s):  
A Horwich
Keyword(s):  
Germ Cell ◽  
Germ Cell Tumour ◽  
Cell Tumour

scholarly journals Germ cell tumour compressing the right atrium

2012 ◽  
Vol 22 (2) ◽  
pp. 86-87 ◽  
Author(s):  
Sait Demirkol ◽  
Oben Baysan ◽  
Turgay Celik ◽  
Bulent Karaman ◽  
Seyfettin Gumus
Keyword(s):  
Germ Cell ◽  
Right Atrium ◽  
Germ Cell Tumour ◽  
Cell Tumour ◽  
The Right
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