scholarly journals Focal splenic lesions in indolent B‐NHL: association with high grade transformation and safe percutaneous biopsy

2020 ◽  
Vol 189 (4) ◽  
Author(s):  
Farheen Mir ◽  
Charlotte Wilding ◽  
Naami Mcaddy ◽  
Nicholas Butterfield ◽  
Larissa Sena ◽  
...  
Keyword(s):  
Percutaneous Biopsy ◽  
High Grade ◽  
High Grade Transformation ◽  
Focal Splenic Lesions

scholarly journals Tumour-Infiltrating Lymphocytes (TILs) and PD-L1 Expression Correlate with Lymph Node Metastasis, High-Grade Transformation and Shorter Metastasis-Free Survival in Patients with Acinic Cell Carcinoma (AciCC) of the Salivary Glands

Cancers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 965
Author(s):  
Selina Hiss ◽  
Markus Eckstein ◽  
Patricia Segschneider ◽  
Konstantinos Mantsopoulos ◽  
Heinrich Iro ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Lymph Node Metastases ◽  
Immune Cell ◽  
High Grade ◽  
Free Survival ◽  
Node Metastasis ◽  
Node Metastases ◽  
High Grade Transformation ◽  
Infiltrating Lymphocytes

Objectives: The aim of this study was to assess the number of tumour-infiltrating lymphocytes (TILs) and the expression of Programmed Cell Death 1 Ligand 1 (PD-L1) in Acinic Cell Carcinoma (AciCC) of the salivary glands, to enable a correlation with clinico-pathological features and to analyse their prognostic impact. Methods: This single centre retrospective study represents a cohort of 36 primary AciCCs with long-term clinical follow-up. Immunohistochemically defined immune cell subtypes, i.e., those expressing T-cell markers (CD3, CD4 and CD8) or a B-cell marker (CD20) were characterized on tumour tissue sections. The number of TILs was quantitatively evaluated using software for digital bioimage analysis (QuPath). PD-L1 expression on the tumour cells and on immune cells was assessed immunohistochemically employing established scoring criteria: tumour proportion score (TPS), Ventana immune cell score (IC-Score) and combined positive score (CPS). Results: Higher numbers of tumour-infiltrating T- and B- lymphocytes were significantly associated with high-grade transformation. Furthermore, higher counts of T-lymphocytes correlated with node-positive disease. There was a significant correlation between higher levels of PD-L1 expression and lymph node metastases as well as the occurrence of high-grade transformation. Moreover, PD-L1 CPS was associated with poor prognosis regarding metastasis-free survival (p = 0.049). Conclusions: The current study is the first to demonstrate an association between PD-L1 expression and lymph node metastases as well as grading in AciCCs. In conclusion, increased immune cell infiltration of T and B cells as well as higher levels of PD-L1 expression in AciCC in association with high-grade transformation, lymph node metastasis and unfavourable prognosis suggests a relevant interaction between tumour cells and immune cell infiltrates in a subset of AciCCs, and might represent a rationale for immune checkpoint inhibition.

scholarly journals Incidence, management, and outcome of high-grade transformation of nodular lymphocyte predominant hodgkin lymphoma: Long-term outcomes from a 30-year experience

2015 ◽  
Vol 90 (6) ◽  
pp. E103-E110 ◽  
Author(s):  
Toby A. Eyre ◽  
Kevin Gatter ◽  
Graham P. Collins ◽  
Georgina W. Hall ◽  
Caroline Watson ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
High Grade ◽  
Long Term Outcomes ◽  
High Grade Transformation

scholarly journals High-Grade Transformation of Acinic Cell Carcinoma: Potentially Underrecognized and Inadequately Treated

2016 ◽  
Vol 94 (4) ◽  
pp. 946
Author(s):  
A.V. Chintakuntlawar ◽  
W. Shon ◽  
M. Erickson-Johnson ◽  
E. Bilodeau ◽  
S. Jenkins ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

ESR1 hotspot mutations in endometrial stromal sarcoma with high-grade transformation and endocrine treatment

2021 ◽  
Author(s):  
Kimberly Dessources ◽  
Kathryn M. Miller ◽  
Elizabeth Kertowidjojo ◽  
Arnaud Da Cruz Paula ◽  
Youran Zou ◽  
...  
Keyword(s):  
Endometrial Stromal Sarcoma ◽  
Endocrine Treatment ◽  
High Grade ◽  
Stromal Sarcoma ◽  
Hotspot Mutations ◽  
High Grade Transformation

High-grade transformation of acinic cell carcinoma: an inadequately treated entity?

2016 ◽  
Vol 121 (5) ◽  
pp. 542-549.e1 ◽  
Author(s):  
Ashish V. Chintakuntlawar ◽  
Wonwoo Shon ◽  
Michele Erickson-Johnson ◽  
Elizabeth Bilodeau ◽  
Sarah M. Jenkins ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Acinic Cell ◽  
High Grade Transformation

Adenoid cystic carcinoma with high-grade transformation forming spindle cell component of the submandibular gland

2019 ◽  
Vol 46 (6) ◽  
pp. 934-939 ◽  
Author(s):  
Masaru Miyazaki ◽  
Mikiko Aoki ◽  
Kaori Koga ◽  
Makoto Hamasaki ◽  
Yoshikazu Sugiyama ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Spindle Cell ◽  
High Grade ◽  
Cell Component ◽  
Spindle Cell Component ◽  
Adenoid Cystic ◽  
High Grade Transformation

High-grade Transformation of Low-grade B-cell Lymphoma

2016 ◽  
Vol 40 (1) ◽  
pp. e1-e16 ◽  
Author(s):  
Rose Lou Marie C. Agbay ◽  
Sanam Loghavi ◽  
L. Jeffrey Medeiros ◽  
Joseph D. Khoury
Keyword(s):  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Low Grade ◽  
High Grade ◽  
High Grade Transformation
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