scholarly journals Sphingosine kinase‐2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl‐1

2020 ◽  
Vol 190 (3) ◽  
pp. 405-417 ◽  
Author(s):  
Francis R. LeBlanc ◽  
Jennifer M. Pearson ◽  
Su‐Fern Tan ◽  
HeeJin Cheon ◽  
Jeffrey C. Xing ◽  
...  
Keyword(s):  
Sphingosine Kinase ◽  
Large Granular Lymphocyte ◽  
Sphingosine Kinase 2 ◽  
Large Granular Lymphocyte Leukaemia

Apoptotic cell extrusion depends on single-cell synthesis of sphingosine-1-phosphate by sphingosine kinase 2

2021 ◽  
Vol 1866 (4) ◽  
pp. 158888
Author(s):  
Bruno Jaime Santacreu ◽  
Daniela Judith Romero ◽  
Lucila Gisele Pescio ◽  
Estefanía Tarallo ◽  
Norma Beatriz Sterin-Speziale ◽  
...  
Keyword(s):  
Single Cell ◽  
Apoptotic Cell ◽  
Sphingosine Kinase ◽  
Sphingosine Kinase 2 ◽  
Sphingosine 1 Phosphate ◽  
Cell Synthesis ◽  
Cell Extrusion

scholarly journals ABC294640, A Novel Sphingosine Kinase 2 Inhibitor, Induces Oncogenic Virus–Infected Cell Autophagic Death and Represses Tumor Growth

2017 ◽  
Vol 16 (12) ◽  
pp. 2724-2734 ◽  
Author(s):  
Lu Dai ◽  
Aiping Bai ◽  
Charles D. Smith ◽  
Paulo C. Rodriguez ◽  
Fangyou Yu ◽  
...  
Keyword(s):  
Infected Cell ◽  
Tumor Growth ◽  
Sphingosine Kinase ◽  
Oncogenic Virus ◽  
Virus Infected Cell ◽  
Sphingosine Kinase 2

Islet Co-Expression of CD133 and ABCB5 in Human Retinoblastoma Specimens

2021 ◽  
Author(s):  
Marco Zschoche ◽  
Sergej Skosyrski ◽  
Neele Babst ◽  
Mahdy Ranjbar ◽  
Felix Rommel ◽  
...  
Keyword(s):  
Treatment Resistance ◽  
Sphingosine Kinase ◽  
Immunohistochemical Analysis ◽  
Pcr Analysis ◽  
Sphingosine Kinase 1 ◽  
Rt Pcr ◽  
Beam Radiation ◽  
Sphingosine Kinase 2 ◽  
Human Retinoblastoma

Abstract Background The role of CD133 und ABCB5 is discussed in treatment resistance in several types of cancer. The objective of this study was to evaluate whether CD133+/ABCB5+ colocalization differs in untreated, in beam radiation treated, and in chemotherapy treated retinoblastoma specimens. Additionally, CD133, ABCB5, sphingosine kinase 1, and sphingosine kinase 2 gene expression was analyzed in WERI-RB1 (WERI RB1) and etoposide-resistant WERI RB1 subclones (WERI ETOR). Methods Active human untreated retinoblastoma specimens (n = 12), active human retinoblastoma specimens pretreated with beam radiation before enucleation (n = 8), and active human retinoblastoma specimens pretreated with chemotherapy before enucleation (n = 7) were investigated for localization and expression of CD133 and ABCB5 by immunohistochemistry. Only specimens with IIRC D, but not E, were included in this study. Furthermore, WERI RB1 and WERI ETOR cell lines were analyzed for CD133, ABCB5, sphingosine kinase 1, and sphingosine kinase 2 by the real-time polymerase chain reaction (RT-PCR). Results Immunohistochemical analysis revealed the same amount of CD133+/ABCB5+ colocalization islets in untreated and treated human retinoblastoma specimens. Quantitative RT-PCR analysis showed a statistically significant upregulation of CD133 in WERI ETOR (p = 0.002). No ABCB5 expression was detected in WERI RB1 and WERI ETOR. On the other hand, SPHK1 (p = 0.0027) and SPHK2 (p = 0.017) showed significant downregulation in WERI ETOR compared to WERI RB1. Conclusions CD133+/ABCB5+ co-localization islets were noted in untreated and treated human retinoblastoma specimens. Therefore, we assume that CD133+/ABCB5+ islets might play a role in retinoblastoma genesis, but not in retinoblastoma treatment resistance.

Sphingosine Kinase 2 (SPHK2)

2018 ◽  
pp. 5119-5128
Author(s):  
Heidi Neubauer ◽  
Stuart Pitson
Keyword(s):  
Sphingosine Kinase ◽  
Sphingosine Kinase 2

scholarly journals Regulation of p21 Expression by Sphingosine Kinase 2

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Nitai C Hait ◽  
Sheldon Milstien ◽  
Sarah Spiegel
Keyword(s):  
Sphingosine Kinase ◽  
Sphingosine Kinase 2
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