New prognosis score including absolute lymphocyte/monocyte ratio, red blood cell distribution width and beta‐2 microglobulin in patients with diffuse large B‐cell lymphoma treated with R‐CHOP: Spanish Lymphoma Group Experience (GELTAMO)

2019 ◽  
Vol 188 (6) ◽  
pp. 888-897 ◽  
Author(s):  
Leyre Bento ◽  
Antonio Díaz‐López ◽  
Gilberto Barranco ◽  
Ana M. Martín‐Moreno ◽  
Mónica Baile ◽  
...  
Keyword(s):  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Beta 2 Microglobulin ◽  
Group Experience ◽  
Prognosis Score ◽  
Red Blood Cell Distribution ◽  
Large B Cell

scholarly journals Prognostic significance of the red blood cell distribution width in diffuse large B-cell lymphoma patients

Oncotarget ◽  
2017 ◽  
Vol 8 (25) ◽  
pp. 40724-40731 ◽  
Author(s):  
Shujuan Zhou ◽  
Fang Fang ◽  
Huiyao Chen ◽  
Wei Zhang ◽  
Yang Chen ◽  
...  
Keyword(s):  
Blood Cell ◽  
B Cell ◽  
Cell Lymphoma ◽  
Prognostic Significance ◽  
B Cell Lymphoma ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Red Blood Cell Distribution ◽  
Large B Cell

scholarly journals Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

BMC Cancer ◽  
2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Manman Li ◽  
Hailong Xia ◽  
Huimin Zheng ◽  
Yafeng Li ◽  
Jun Liu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Cell Lymphoma ◽  
Predictive Ability ◽  
B Cell Lymphoma ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Kaplan Meier ◽  
Red Blood Cell Distribution ◽  
Large B Cell

Abstract Background Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients. However, their prognostic values in patients with diffuse large B-cell lymphoma (DLBCL) need to be further explored. Methods Healthy donors (n = 130) and patients with DLBCL (n = 349) were included and evaluated retrospectively in this study. The prognostic influence of clinical and pathological factors including RDW and PLT on overall survival (OS) and progression-free survival (PFS) were studied by Kaplan-Meier curves. To evaluate the independent prognostic relevance of RDW and PLT, univariate and multivariate Cox proportional hazards regression models were applied. The adjusted IPI model was established based on the results of multivariate analysis, and verified by Harrell’s C statistical analysis. Results Kaplan-Meier curves indicated that an elevated RDW value and thrombocytopenia are poor factors for OS (P < 0.001, P = 0.006) and PFS (P = 0.003, P < 0.001) in DLBCL patients. Multivariate analysis confirmed that elevated RDW value (HR = 2.026, 95%CI = 1.263–3.250, P = 0.003) and decreased PLT count (HR =1.749, 95%CI = 1.010–3.028, P = 0.046) were both independent prognostic factors. The c-index of IPI and NCCN-IPI were increased when RDW level and PLT were supplemented in our cohort. Conclusions Our study shows that elevated RDW level and decreased PLT are independent poor prognostic factors in newly diagnosed DLBCL patients. Adding RDW and PLT to the IPI score may improve its predictive ability, and the adjusted IPI may be more powerful in predicting the survival of DLBCL patients in the rituximab era.

scholarly journals Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

2019 ◽  
Author(s):  
Manman Li ◽  
Hailong Xia ◽  
Huimin Zheng ◽  
Yafeng Li ◽  
Jun Liu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Red Blood Cell Distribution ◽  
Large B Cell

Abstract Background: Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients . However, their prognostic values in patients with diffuse large B-cell lymphoma (DLBCL) need to be further explored. Methods: Healthy donors (n=130) and patients with DLBCL (n=349) were included and evaluated retrospectively in this study. The prognostic influence of clinical and pathological factors including RDW and PLT on overall survival (OS) and progression-free survival (PFS) were studied by Kaplan-Meier curves . To evaluate the independent prognostic relevance of RDW and PLT, univariate and multivariate Cox proportional hazards regression models were applied. The adjusted IPI model was established based on the results of multivariate analysis, and verified by Harrell's C statistical analysis. Results: Kaplan-Meier curves indicated that an elevated RDW value and thrombocytopenia are poor factors for OS (P<0.001, P=0.006) and PFS (P=0.003, P<0.001) in DLBCL patients. Multivariate analysis confirmed that elevated RDW value (HR=2.026, 95%CI= 1.263-3.250, P=0.003) and decreased PLT count (HR =1.749, 95%CI=1.010-3.028, P=0.046) were both independent prognostic factors. The c-index of IPI and NCCN-IPI were increased when RDW level and PLT were supplemented in our cohort. Conclusions: Our study shows that elevated RDW level and decreased PLT are independent poor prognostic factors in newly diagnosed DLBCL patients. Adding RDW and PLT to the IPI score may improve its predictive ability, and the adjusted IPI may be more powerful in predicting the survival of DLBCL patients in the rituximab era. Keywords : prognosis, diffuse large B-cell lymphoma ( DLBCL ), red blood cell distribution width (RDW), platelet count (PLT)

scholarly journals Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

2019 ◽  
Author(s):  
Manman Li ◽  
Hailong Xia ◽  
Huimin Zheng ◽  
Yafeng Li ◽  
Jun Liu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Red Blood Cell Distribution ◽  
Large B Cell

Abstract Background: Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients . However, their prognostic values in patients with diffuse large B-cell lymphoma (DLBCL) need to be further explored. Methods: Healthy donors (n=130) and patients with DLBCL (n=349) were included and evaluated retrospectively in this study. The prognostic influence of clinical and pathological factors including RDW and PLT on overall survival (OS) and progression-free survival (PFS) were studied by Kaplan-Meier curves . To evaluate the independent prognostic relevance of RDW and PLT, univariate and multivariate Cox proportional hazards regression models were applied. The adjusted IPI model was established based on the results of multivariate analysis, and verified by Harrell's C statistical analysis. Results: Kaplan-Meier curves indicated that an elevated RDW value and thrombocytopenia are poor factors for OS (P<0.001, P=0.006) and PFS (P=0.003, P<0.001) in DLBCL patients. Multivariate analysis confirmed that elevated RDW value (HR=2.026, 95%CI= 1.263-3.250, P=0.003) and decreased PLT count (HR =1.749, 95%CI=1.010-3.028, P=0.046) were both independent prognostic factors. The c-index of IPI and NCCN-IPI were increased when RDW level and PLT were supplemented in our cohort. Conclusions: Our study shows that elevated RDW level and decreased PLT are independent poor prognostic factors in newly diagnosed DLBCL patients. Adding RDW and PLT to the IPI score may improve its predictive ability, and the adjusted IPI may be more powerful in predicting the survival of DLBCL patients in the rituximab era. Keywords : prognosis, diffuse large B-cell lymphoma ( DLBCL ), red blood cell distribution width (RDW), platelet count (PLT)

scholarly journals Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

2019 ◽  
Author(s):  
Manman Li ◽  
Hailong Xia ◽  
Huimin Zheng ◽  
Yafeng Li ◽  
Jun Liu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Red Blood Cell Distribution ◽  
Large B Cell

Abstract Background: Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients . However, their prognostic values in patients with diffuse large B-cell lymphoma (DLBCL) need to be further explored. Methods: Healthy donors (n=130) and patients with DLBCL (n=349) were included and evaluated retrospectively in this study. The prognostic influence of clinical and pathological factors including RDW and PLT on overall survival (OS) and progression-free survival (PFS) were studied by Kaplan-Meier curves . To evaluate the independent prognostic relevance of RDW and PLT, univariate and multivariate Cox proportional hazards regression models were applied. The adjusted IPI model was established based on the results of multivariate analysis, and verified by Harrell's C statistical analysis. Results: Kaplan-Meier curves indicated that an elevated RDW value and thrombocytopenia are poor factors for OS (P<0.001, P=0.006) and PFS (P=0.003, P<0.001) in DLBCL patients. Multivariate analysis confirmed that elevated RDW value (HR=2.026, 95%CI= 1.263-3.250, P=0.003) and decreased PLT count (HR =1.749, 95%CI=1.010-3.028, P=0.046) were both independent prognostic factors. The c-index of IPI and NCCN-IPI were increased when RDW level and PLT were supplemented in our cohort. Conclusions: Our study shows that elevated RDW level and decreased PLT are independent poor prognostic factors in newly diagnosed DLBCL patients. Adding RDW and PLT to the IPI score may improve its predictive ability, and the adjusted IPI may be more powerful in predicting the survival of DLBCL patients in the rituximab era. Keywords : prognosis, diffuse large B-cell lymphoma ( DLBCL ), red blood cell distribution width (RDW), platelet count (PLT)

scholarly journals Red blood cell distribution width and platelet counts are independent prognostic factors and improve the predictive ability of IPI score in diffuse large B-cell lymphoma patients

2019 ◽  
Author(s):  
Manman Li ◽  
Hailong Xia ◽  
Huimin Zheng ◽  
Yafeng Li ◽  
Jun Liu ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Red Blood Cell Distribution ◽  
Large B Cell

Abstract Elevated red blood cell distribution width (RDW) and decreased platelet count (PLT) can be clinically relevant to the prognosis in cancer patients . However, their prognostic value in patients with diffuse large B-cell lymphoma (DLBCL) is needed to be further explored. Healthy donors (n=130) and patients with DLBCL (n=349) were included and evaluated retrospectively in the study. The prognostic influence of clinical and pathological factors including RDW and PLT on OS and PFS were studied by Kaplan-Meier curves . To evaluate the independent prognostic relevance of RDW and PLT, univariate and multivariate Cox proportional hazards regression models were applied. The adjusted IPI model was established based on the results of multivariate analysis, and verified by Harrell's C statistical analysis. Kaplan-Meier curves indicated elevated RDW value and thrombocytopenia are poor factors for OS (P<0.001, P=0.006) and PFS (P=0.003, P<0.001) in DLBCL patients. Multivariate analysis confirmed that elevated RDW value (HR=2.026, 95%CI= 1.263-3.250, P=0.003) and decreased PLT (HR =1.749, 95%CI=1.010-3.028, P=0.046) both were independent prognostic factors. The c-index of IPI and NCCN-IPI was increased when RDW level and PLT were supplemented in our cohort. Our study shows that elevated RDW level and decreased PLT are independent poor prognostic factors in newly diagnosed DLBCL patients. Adding RDW and PLT to the IPI score may improve its predictive ability, and the adjusted IPI may be more powerful in predicting the survival of DLBCL patients in the rituximab era. Keywords : prognosis, diffuse large B-cell lymphoma ( DLBCL ), red blood cell distribution width (RDW), platelet count (PLT)

scholarly journals PROGNOSTIC VALUE OF RED CELL DISTRIBUTION WIDTH AT DIAGNOSIS (RDW) IN DIFFUSE LARGE B‐CELL LYMPHOMA

2021 ◽  
Vol 39 (S2) ◽  
Author(s):  
J.M. Raya ◽  
P. López‐García ◽  
C. D. Reyes ◽  
M.J. Rodríguez‐Salazar ◽  
C. De Bonis ◽  
...  
Keyword(s):  
B Cell ◽  
Prognostic Value ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Red Cell Distribution Width ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Prognostic value of absolute lymphocyte/monocyte ratio, red cell distribution width and neutrophil/ lymphocyte ratio in diffuse large B-cell lymphoma patients

2021 ◽  
Vol 67 (3) ◽  
pp. 61-68
Author(s):  
Kawa Muhamedamin Hasan ◽  
Ahmed Yassin Elmeshhedany
Keyword(s):  
Cell Lymphoma ◽  
Performance Status ◽  
B Cell Lymphoma ◽  
Rank Test ◽  
Red Cell ◽  
Cell Distribution ◽  
Distribution Width ◽  
Log Rank Test ◽  
Large B Cell Lymphoma ◽  
Large B Cell

Diffuse large B-cell lymphoma (DLBCL) is an aggressive and rapid-growing form of non-Hodgkin lymphoma (NHL). The objective of this research was to assess the predictive role of lymphocyte to monocyte ratio (LMR), red cell distribution width (RDW) and neutrophil to lymphocyte ratio (NLR) values in the survival of DLBCL patients. A retrospective analysis of 136 DLBCL patients admitted to Nanakali Hospital for blood diseases and oncology from 2010-2020 was done. We assessed the correlation of LMR, RDW and NLR with patients’ characteristics and the impact on survival by the Kaplan–Meier method, the log-rank test, and Cox regression models for multivariate analysis. The complete remission rate was 61.7%, with a 5- year overall survival (OS) and progression-free survival (PFS) of 59.5% and 60%, respectively. The Log-rank test showed that LMR was significantly correlated with Ann Arbor staging (p= 0.040). There is a significant association between RDW and Eastern Cooperative Oncology Group performance status (ECOG-performance status) (p= 0.022), B symptoms (p= 0.026), Revised International prognostic index (R-IPI) (p= 0.004), lactate dehydrogenase (LDH) (p= 0.021), and beta 2 microglobulin (B2MG) (p= 0.007), whereas NLR had a significant correlation with LDH only (p=0.016). There were no significant differences in the 5-year OS or PFS in patients with different levels of RDW, LMR, and NLR. LMR, RDW and NLR were correlated with many of patients’ characteristics. However, none of the LMR, RDW and NLR did possess value to predict OS and PFS, and they cannot be used as biomarkers for survival evaluation of DLBCL.

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