Upregulation of AKR1C1 in mesenchymal stromal cells promotes the survival of acute myeloid leukaemia cells

2020 ◽  
Vol 189 (4) ◽  
pp. 694-706 ◽  
Author(s):  
Yajing Jiang ◽  
Ying Li ◽  
Jingying Cheng ◽  
Jiao Ma ◽  
Qinghua Li ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Acute Myeloid

scholarly journals Daratumumab inhibits acute myeloid leukaemia metabolic capacity by blocking mitochondrial transfer from mesenchymal stromal cells

Haematologica ◽  
2020 ◽  
pp. haematol.2019.242974 ◽  
Author(s):  
Jayna J Mistry ◽  
Jamie A Moore ◽  
Prakritt Kumar ◽  
Christopher R Marlein ◽  
Charlotte Hellmich ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Metabolic Capacity ◽  
Mitochondrial Transfer ◽  
Acute Myeloid

scholarly journals An ex vivo investigation of interactions between primary acute myeloid leukaemia and mesenchymal stromal cells yields novel therapeutic targets

2020 ◽  
Vol 190 (4) ◽  
Author(s):  
Avirup Chowdhury ◽  
Sandra Loaiza ◽  
Eva Yebra‐Fernandez ◽  
Elisabet Nadal‐Melsio ◽  
Jane F. Apperley ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Ex Vivo ◽  
Therapeutic Targets ◽  
Acute Myeloid ◽  
Novel Therapeutic

scholarly journals Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells

2021 ◽  
Author(s):  
Nuria Vilaplana-Lopera ◽  
Ruba Almaghrabi ◽  
Grigorios Papatzikas ◽  
Elena González ◽  
Alan Cunningham ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Adjuvant Therapy ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Transcriptome Analysis ◽  
Stromal Cells ◽  
Oxygen Species ◽  
Nmr Studies ◽  
Metabolic Interactions ◽  
Acute Myeloid

SummaryAcute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, it is unclear whether AML cells could establish beneficial metabolic interactions with stromal cells. Here, we identify a novel metabolic crosstalk between AML and stromal cells where AML cells prompt stromal cells to secrete acetate for their own consumption. By performing transcriptome analysis and tracer-based NMR studies, we show that stromal cells present a higher rate of glycolysis, and that the secreted acetate derives from pyruvate via a reactive oxygen species (ROS)-mediated process. Our data also reveals that AML cells transfer ROS to stromal cells using gap junctions. Overall, we present a unique metabolic communication between AML and stromal cells that could be exploited as adjuvant therapy.

The acute myeloid leukaemia market

2019 ◽  
Vol 19 (4) ◽  
pp. 233-234
Author(s):  
Jorrit Schaefer ◽  
Sorcha Cassidy ◽  
Rachel M. Webster
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Myeloid
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