scholarly journals Graft‐versus‐host disease and graft‐versus‐leukaemia effects in secondary acute myeloid leukaemia: a retrospective, multicentre registry analysis from the Acute Leukaemia Working Party of the EBMT

2019 ◽  
Vol 188 (3) ◽  
pp. 428-437
Author(s):  
Frédéric Baron ◽  
Myriam Labopin ◽  
Bipin N. Savani ◽  
Eric Beohou ◽  
Dietger Niederwieser ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Graft Versus Host Disease ◽  
Acute Leukaemia ◽  
Working Party ◽  
Host Disease ◽  
Graft Versus Host ◽  
Registry Analysis ◽  
Acute Myeloid

Eosinophil chimerism in the differential diagnosis between DEK-NUP214-positive acute myeloid leukaemia relapse and chronic graft-versus-host disease

2015 ◽  
Vol 68 (11) ◽  
pp. 950-952 ◽  
Author(s):  
Clarissa Lima e Moura de Souza ◽  
Carolina Bonet Bub ◽  
Margareth Afonso Torres ◽  
Elvira Deolinda Rodrigues Pereira Velloso ◽  
Paulo Augusto Achucarro Silveira ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Leukaemia Relapse ◽  
Acute Myeloid

scholarly journals A fast and fatal course of bronchiectasis: an unusual rare expression of chronic graft versus host disease. A case report

2016 ◽  
Vol 23 (1) ◽  
pp. 54-59
Author(s):  
Violeta Labžentytė ◽  
Silvija Zemnickienė ◽  
Edvardas Danila ◽  
Virginija Šileikienė ◽  
Rolandas Zablockis ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Ct Scan ◽  
Myeloid Leukaemia ◽  
Graft Versus Host Disease ◽  
Host Disease ◽  
Graft Versus Host ◽  
Allogeneic Bmt ◽  
Fast Progression ◽  
Fatal Course ◽  
Acute Myeloid

Introduction. We report a case of a patient with acute myeloid leukaemia whose treatment with bone marrow transplantation (BMT) was followed by chronic graft versus host disease (GVHD) with lung involvement and bronchiectasis. This report illustrates an unusual course of a fast progression of the bronchiectasis due to BMT. Case description. A  33-year-old female was diagnosed with acute myeloid leukaemia. An allogeneic BMT was performed. One month after the  transplantation, acute GVHD with skin involvement occurred. Treatment with prednisolone and mycophenolate mofetil (MMF) has been started. Nine months later, the patient was examined by a pulmonologist due to progressive dyspnoea. A pulmonary computed tomography (CT) scan showed normal parenchyma of the lungs and no changes to the bronchi. A CT scan performed 7 months later revealed bronchiectasis for the first time. No clinical response was associated with the treatment and the patient’s respiratory status progressively deteriorated. During the  final hospitalization, a CT scan performed 1 year later revealed huge cystic bronchiectasis in both lungs. Despite the prophylaxis and treatment of GVHD and aggressive antimicrobial therapy, the patient died one year after the diagnosis of bronchiectasis. Conclusions. This case demonstrates that a fast and fatal course of bronchiectasis, that occurs after BMT, should always be considered as a possible manifestation of chronic graft versus host disease (cGVHD) following allogeneic BMT.

scholarly journals Allogeneic haemopoietic transplantation for acute myeloid leukaemia in second complete remission: a registry report by the Acute Leukaemia Working Party of the EBMT

Leukemia ◽  
2019 ◽  
Vol 34 (1) ◽  
pp. 87-99 ◽  
Author(s):  
Maria H. Gilleece ◽  
Myriam Labopin ◽  
Bipin N. Savani ◽  
Ibrahim Yakoub-Agha ◽  
Gerard Socié ◽  
...  
Keyword(s):  
Complete Remission ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Leukaemia ◽  
Working Party ◽  
Registry Report ◽  
Acute Myeloid

Aberrant Expression of CD Markers in Acute Myeloid Leukaemia

2018 ◽  
Vol 2 (01) ◽  
pp. 14-16
Author(s):  
Abul Kalam Azad ◽  
Md. Rafiquzzaman Khan ◽  
ABM Hasan Habib ◽  
Md. Abdul Wadud Miah ◽  
Masuda Begum
Keyword(s):  
Flow Cytometry ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Leukaemia ◽  
Antigen Expression ◽  
Aberrant Expression ◽  
Female Ratio ◽  
Cd Antigen ◽  
Cd Markers ◽  
Acute Myeloid

Background: Aberrant expression of cluster differentiation (CD) antigen marker is associated with poor outcome of acute leukaemia. Objective: Aim of this study is to determine the frequency and pattern of aberrant expression of CD markers in acute myeloid leukaemia patients in Bangladesh. Methods: This retrospective data analysis was conducted in the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) to assess the frequency of aberrant CD antigen expression in acute myeloid leukaemia from October 2016 to September 2017. During this period, we did one hundred flow cytometry of acute leukaemia patients and among them we found 48 acute myeloid Leukaemia (AML) who were included in this study. Result: Mean age of patients was 35 years (SD­ +14 years; Rang 3 to 50 years) with male: female ratio of 0.92. Four colour flow cytometry was done on fresh bone marrow aspirates and peripheral blood. Among 48 AML patients, aberrant CD expression was observed in 58% cases.  CD5 and cCD79a lymphoid markers were seen to be expressed in 32% cases of AML. Aberrant cCD3 and CD7 were expressed in 29% and 25% cases respectively and aberrant CD10, CD19, cCD22 were expressed in 11%, 3%, 3% cases acute myeloid leukaemia patients respectively. Conclusion: Aberrant CD antigen expression is not uncommon in AML patients of Bangladeshi population that may adversely affect the treatment outcome of the disease.

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