International external quality assessment for measurements of direct oral anticoagulants: results and recommendations

2019 ◽  
Vol 188 (3) ◽  
pp. 460-464
Author(s):  
Martine J. Hollestelle ◽  
Piet Meijer
Keyword(s):  
Quality Assessment ◽  
External Quality Assessment ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
External Quality

scholarly journals 109Accuracy of test results for Direct Oral Anticoagulants (DOACs) and Warfarin- importance of External Quality Assessment (EQA)

EP Europace ◽  
2017 ◽  
Vol 19 (suppl_1) ◽  
pp. i46-i46
Author(s):  
DP Kitchen ◽  
A W-C Chow ◽  
S Munroe-Peart ◽  
L Brown ◽  
I Jennings ◽  
...  
Keyword(s):  
Quality Assessment ◽  
External Quality Assessment ◽  
Oral Anticoagulants ◽  
Direct Oral Anticoagulants ◽  
Test Results ◽  
External Quality

scholarly journals The versatility of external quality assessment for the surveillance of laboratory and in vitro diagnostic performance: SARS-CoV-2 viral genome detection in Austria

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Christoph Buchta ◽  
Jeremy V. Camp ◽  
Jovana Jovanovic ◽  
Peter Chiba ◽  
Elisabeth Puchhammer-Stöckl ◽  
...  
Keyword(s):  
Quality Assessment ◽  
External Quality Assessment ◽  
False Negative ◽  
Positive Sample ◽  
Performance Criteria ◽  
External Quality ◽  
Assay Sensitivity ◽  
Dilution Series ◽  
Test Systems

Abstract Objectives External quality assessment (EQA) schemes provide information on individual and general analytical performance of participating laboratories and test systems. The aim of this study was to investigate the use and performance of SARS-CoV-2 virus genome detection systems in Austrian laboratories and their preparedness to face challenges associated with the pandemic. Methods Seven samples were selected to evaluate performance and estimate variability of reported results. Notably, a dilution series was included in the panel as a measure of reproducibility and sensitivity. Several performance criteria were evaluated for individual participants as well as in the cohort of all participants. Results A total of 109 laboratories participated and used 134 platforms, including 67 different combinations of extraction and PCR platforms and corresponding reagents. There were no false positives and 10 (1.2%) false negative results, including nine in the weakly positive sample (C t ∼35.9, ∼640 copies/mL). Twenty (22%) laboratories reported results of mutation detection. Twenty-five (19%) test systems included amplification of human RNA as evidence of proper sampling. The overall linearity of C t values from individual test systems for the dilution series was good, but inter-assay variability was high. Both operator-related and systematic failures appear to have caused incorrect results. Conclusions Beyond providing certification for participating laboratories, EQA provides the opportunity for participants to evaluate their performance against others so that they may improve operating procedures and test systems. Well-selected EQA samples offer additional inferences to be made about assay sensitivity and reproducibility, which have practical applications.

Commutability of possible external quality assessment materials for progesterone measurement

2021 ◽  
Vol 87 ◽  
pp. 39-45
Author(s):  
Xilian Yi ◽  
Yufei Wang ◽  
Tianjiao Zhang ◽  
Jie Zeng ◽  
Haijian Zhao ◽  
...  
Keyword(s):  
Quality Assessment ◽  
External Quality Assessment ◽  
External Quality

Appropriateness of cholesterol and triglycerides reporting checked by External Quality Assessment programs

2003 ◽  
Vol 333 (2) ◽  
pp. 221-230 ◽  
Author(s):  
Sandra Secchiero ◽  
Laura Sciacovelli ◽  
Lorena Zardo ◽  
Mario Plebani
Keyword(s):  
Quality Assessment ◽  
External Quality Assessment ◽  
External Quality
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