scholarly journals Treatment efficacy for adult persistent immune thrombocytopenia: a systematic review and network meta‐analysis

2019 ◽  
Vol 188 (3) ◽  
pp. 450-459 ◽  
Author(s):  
Teeraya Puavilai ◽  
Kunlawat Thadanipon ◽  
Sasivimol Rattanasiri ◽  
Atiporn Ingsathit ◽  
Mark McEvoy ◽  
...  
Keyword(s):  
Systematic Review ◽  
Treatment Efficacy ◽  
Immune Thrombocytopenia ◽  
Meta Analysis

Therapies for Onychomycosis

2015 ◽  
Vol 105 (4) ◽  
pp. 357-366 ◽  
Author(s):  
Aditya K. Gupta ◽  
Deanne Daigle ◽  
Maryse Paquet
Keyword(s):  
Systematic Review ◽  
Clinical Practice ◽  
Treatment Efficacy ◽  
Meta Analysis ◽  
Pulse Therapy ◽  
Controlled Trials ◽  
Review Of The Literature ◽  
Mycological Cure ◽  
Randomized Controlled ◽  
Topical Treatments

New therapies for onychomycosis continue to be developed, yet treatments are seldom directly compared in randomized controlled trials. The objective of this study was to compare the rates of mycological cure for oral and topical onychomycosis treatments using network meta-analysis. A systematic review of the literature on onychomycosis treatments published before March 25, 2013, was performed, and data were analyzed using network meta-analysis. Terbinafine, 250 mg, therapy was significantly superior to all treatments except itraconazole, 400 mg, pulse therapy; itraconazole, 200 mg, therapy was significantly superior to fluconazole and the topical treatments; and fluconazole, efinaconazole, ciclopirox, terbinafine nail solution, and amorolfine treatments were significantly superior to only placebo. These results support the superiority of 12-week continuous terbinafine, 250 mg, therapy and itraconazole, 400 mg, pulse therapy (1 week per month for 3 months) while suggesting the equivalence of topical therapies. These results reflect findings from the literature and treatment efficacy observed in clinical practice.

scholarly journals Methotrexate for the Treatment of Pediatric Crohn’s Disease: A Systematic Review and Meta-analysis

2018 ◽  
Vol 24 (10) ◽  
pp. 2135-2141 ◽  
Author(s):  
Ruben J Colman ◽  
Rachel C Lawton ◽  
Marla C Dubinsky ◽  
David T Rubin
Keyword(s):  
Systematic Review ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Combination Therapy ◽  
Treatment Efficacy ◽  
Clinical Remission ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Free Text ◽  
Pediatric Ibd

Abstract Background Methotrexate (MTX) is an immunomodulator used for the treatment of pediatric inflammatory bowel disease (IBD). There are currently no RCTs that assess the treatment efficacy of methotrexate within the pediatric IBD patient population. This systematic review and meta-analysis assesses the efficacy of MTX therapy among the existing pediatric literature. Methods A systematic literature search was performed using MEDLINE and the Cochrane library from inception until March 2016. Synonyms for ‘pediatric’, ‘methotrexate’ and ‘IBD’ were utilized as both free text and MESH search terms. The studies included contained clinical remission (CR) rates for MTX treatment of pediatric IBD patients 18 yrs old, as mono- or combination therapy. Case studies with <10 patients were excluded. Quality assessment was performed with the Newcastle-Ottawa Scale. Meta-analysis calculated pooled CR rates. A random-effects meta-analysis with forest plots was performed using R. Results Fourteen (11 monotherapy, 1 combination therapy, 2 both; n = 886 patients) observational studies were eligible out of 202 studies. No interventional studies were identified. The pooled achieved CR rate for pediatric CD patients on monotherapy within 3-6 months was 57.7% (95% CI 48.2-66.6%), (P =0.22; I2 = 29.8%). The CR was 37.1% (95% CI 29.5-45.5%), (P = 0.20; I2 = 37.4%) for maintenance therapy at 12 months. Sub-analysis could not identify CR differences between MTX administration types, thiopurine exposure. Conclusions This meta-analysis demonstrated that, over 50% of pediatric Crohn’s disease patients induced with methotrexate achieved clinical remission, while 12-month remission rate was only 37%. Prospective controlled interventional trials should assess treatment efficacy among patient subgroups.

scholarly journals Comparison of up-front treatments for newly diagnosed immune thrombocytopenia -a systematic review and network meta-analysis

Haematologica ◽  
2017 ◽  
Vol 103 (1) ◽  
pp. 163-171 ◽  
Author(s):  
Yasuyuki Arai ◽  
Tomoyasu Jo ◽  
Hiroyuki Matsui ◽  
Tadakazu Kondo ◽  
Akifumi Takaori-Kondo
Keyword(s):  
Systematic Review ◽  
Immune Thrombocytopenia ◽  
Meta Analysis ◽  
Newly Diagnosed

scholarly journals The sensitivity and specificity of platelet autoantibody testing in immune thrombocytopenia: a systematic review and meta‐analysis of a diagnostic test

2019 ◽  
Vol 17 (5) ◽  
pp. 787-794 ◽  
Author(s):  
John R. Vrbensky ◽  
Joyce E. Moore ◽  
Donald M. Arnold ◽  
James W. Smith ◽  
John G. Kelton ◽  
...  
Keyword(s):  
Systematic Review ◽  
Diagnostic Test ◽  
Sensitivity And Specificity ◽  
Immune Thrombocytopenia ◽  
Meta Analysis

scholarly journals Treatment Efficacy for Non-Cardiovascular Chest Pain: A Systematic Review and Meta-Analysis

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104722 ◽  
Author(s):  
Jakob M. Burgstaller ◽  
Boris F. Jenni ◽  
Johann Steurer ◽  
Ulrike Held ◽  
Maria M. Wertli
Keyword(s):  
Systematic Review ◽  
Chest Pain ◽  
Treatment Efficacy ◽  
Meta Analysis
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