scholarly journals Longitudinal trend analysis of serum transferrin receptor‐1 level in a cohort of patients affected by non‐transfusion dependent thalassaemia

2019 ◽  
Vol 186 (5) ◽  
Author(s):  
Paolo Ricchi ◽  
Massimiliano Ammirabile ◽  
Silvia Costantini ◽  
Anna Spasiano ◽  
Patrizia Cinque ◽  
...  
Keyword(s):  
Trend Analysis ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor ◽  
Longitudinal Trend ◽  
Transferrin Receptor 1

scholarly journals Soluble serum transferrin receptor and transferrin receptor-ferritin index in anemia of chronic kidney disease

2006 ◽  
Vol 35 (8) ◽  
pp. 520-543 ◽  
Author(s):  
Sandra Margetic ◽  
Elizabeta Topic ◽  
Andrea Tesija-Kuna ◽  
Ines Vukasovic
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

scholarly journals Erythroblastic Inclusions in Dominantly Inherited β Thalassemias

Blood ◽  
1997 ◽  
Vol 89 (1) ◽  
pp. 322-328 ◽  
Author(s):  
P. Joy Ho ◽  
Sunitha N. Wickramasinghe ◽  
David C. Rees ◽  
Matthew J. Lee ◽  
Ayed Eden ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Inclusion Bodies ◽  
Serum Transferrin ◽  
Mrna Transcript ◽  
Globin Chain ◽  
Prominent Feature ◽  
Ineffective Erythropoiesis ◽  
Serum Transferrin Receptor ◽  
Globin Chains ◽  
Cellular Pathology

While the precipitation of unstable variant β-globin chains has been implicated as a major pathogenic mechanism in dominantly inherited β thalassemia, their instability and presence in intra-erythroblastic inclusions have not been conclusively shown. We report the investigation of two cases of dominantly inherited β thalassemia due to heterozygosity for the β-codon 121 G-T mutation. In one case, we were able to demonstrate the presence of an abnormal β-globin chain in both peripheral blood reticulocytes and bone marrow erythroblasts, and to assess its stability in relation to the substantial amounts of mutant β mRNA transcript. The serum transferrin receptor (TfR) level was markedly increased, an indication of increased erythropoietic activity. In both cases, we could show by immunoelectron microscopy that the intra-erythroblastic inclusion bodies, a prominent feature of diseases in this category, contained not only precipitated α-globin chains, but also β chains. The data confirm previous suggestions that the cellular pathology underlying this group of β thalassemias is related to the synthesis of highly unstable β-globin chain variants, which fail to form functional tetramers and precipitate intracellularly with the concomitant excess α chains, leading to increased ineffective erythropoiesis.

scholarly journals Serum Transferrin Receptor Levels in Different Stages of Iron Deficiency

Blood ◽  
1997 ◽  
Vol 90 (3) ◽  
pp. 1332-1333
Author(s):  
E. Gimferrer ◽  
J. Ubeda ◽  
M.T. Royo ◽  
G.J. Marigó ◽  
N. Marco ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

EPO, red cells, and serum transferrin receptor in continuous and intermittent hypoxia

2000 ◽  
Vol 32 (4) ◽  
pp. 800-804 ◽  
Author(s):  
PENTTI O. KOISTINEN ◽  
HEIKKI RUSKO ◽  
KERTTU IRJALA ◽  
ALLAN RAJAM??KI ◽  
KENNETH PENTTINEN ◽  
...  
Keyword(s):  
Transferrin Receptor ◽  
Intermittent Hypoxia ◽  
Red Cells ◽  
Serum Transferrin ◽  
Serum Transferrin Receptor

scholarly journals Increased Serum Transferrin Saturation Is Associated with Lower Serum Transferrin Receptor Concentration

1999 ◽  
Vol 45 (12) ◽  
pp. 2191-2199 ◽  
Author(s):  
Anne C Looker ◽  
Mark Loyevsky ◽  
Victor R Gordeuk
Keyword(s):  
Iron Deficiency ◽  
Iron Overload ◽  
Transferrin Receptor ◽  
Iron Status ◽  
Transferrin Saturation ◽  
Reference Interval ◽  
Serum Transferrin ◽  
Reactive Protein ◽  
Serum Transferrin Receptor ◽  
Health And Nutrition

Abstract Background: Serum transferrin receptor (sTfR) concentrations are increased in iron deficiency. We wished to examine whether they are decreased in the presence of potential iron-loading conditions, as reflected by increased transferrin saturation (TS) on a single occasion. Methods: We compared sTfR concentrations between 570 controls with normal iron status and 189 cases with increased serum TS on a single occasion; these latter individuals may be potential cases of iron overload. Cases and controls were selected from adults who had been examined in the third National Health and Nutrition Examination Survey (1988–1994) and for whom excess sera were available to perform sTfR measurements after the survey’s completion. Increased TS was defined as >60% for men and >55% for women; normal iron status was defined as having no evidence of iron deficiency, iron overload, or inflammation indicated by serum ferritin, TS, erythrocyte protoporphyrin, and C-reactive protein. Results: Mean sTfR and mean log sTfR:ferritin were ∼10% and 24% lower, respectively, in cases than in controls (P <0.002). Cases were significantly more likely to have an sTfR value <2.9 mg/L, the lower limit of the reference interval, than were controls (odds ratio = 1.8; 95% confidence interval, 1.04–2.37). Conclusion: Our results support previous studies that suggested that sTfR may be useful for assessing high iron status in populations.

scholarly journals Serum Transferrin Receptor and Its Ratio to Serum Ferritin in the Diagnosis of Iron Deficiency

Blood ◽  
1997 ◽  
Vol 89 (3) ◽  
pp. 1052-1057 ◽  
Author(s):  
Kari Punnonen ◽  
Kerttu Irjala ◽  
Allan Rajamäki
Keyword(s):  
Bone Marrow ◽  
Iron Deficiency ◽  
Transferrin Receptor ◽  
Laboratory Tests ◽  
Bone Marrow Examination ◽  
Deficiency Anemia ◽  
Serum Transferrin ◽  
Iron Stores ◽  
Serum Transferrin Receptor ◽  
Reference Limits

Abstract The objective of the study was to evaluate the diagnostic efficiency of laboratory tests, including serum transferrin receptor (TfR) measurements, in the diagnosis of iron depletion. The patient population consisted of 129 consecutive anemic patients at the University Hospital of Turku who were given a bone marrow examination. Of these patients, 48 had iron deficiency anemia (IDA), 64 anemia of chronic disease (ACD), and 17 patients had depleted iron stores and an infectious or an inflammatory condition (COMBI). Depletion of iron stores was defined as a complete absence of stainable iron in the bone marrow examination. Serum TfR concentrations were elevated in the vast majority of the IDA and COMBI patients, while in the ACD patients, the levels were within the reference limits reported earlier for healthy subjects. TfR measurement thus provided a reliable diagnosis of iron deficiency anemia (AUCROC 0.98). Serum ferritin measurement also distinguished between IDA patients and ACD patients. However, the optimal decision limit for evaluation of ferritin measurements was considerably above the conventional lower reference limits, complicating the interpretation of this parameter. Calculation of the ratio TfR/log ferritin (TfR-F Index) is a way of combining TfR and ferritin results. This ratio provided an outstanding parameter for the identification of patients with depleted iron stores (AUCROC 1.00). In anemic patients, TfR measurement is a valuable noninvasive tool for the diagnosis of iron depletion, and offers an attractive alternative to more conventional laboratory tests in the detection of depleted iron stores.

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