scholarly journals Risk factors for Burkitt lymphoma: a nested case-control study in the UK Clinical Practice Research Datalink

2018 ◽  
Vol 181 (4) ◽  
pp. 505-514 ◽  
Author(s):  
Parisa Karimi ◽  
Brenda M. Birmann ◽  
Lesley A. Anderson ◽  
Charlene M. McShane ◽  
Shahinaz M. Gadalla ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Practice ◽  
Burkitt Lymphoma ◽  
Case Control Study ◽  
Case Control ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
The Uk ◽  
Nested Case Control ◽  
Control Study

scholarly journals Depression in individuals who subsequently develop inflammatory bowel disease: a population-based nested case–control study

Gut ◽  
2020 ◽  
pp. gutjnl-2020-322308 ◽  
Author(s):  
Jonathan Blackwell ◽  
Sonia Saxena ◽  
Irene Petersen ◽  
Matthew Hotopf ◽  
Hanna Creese ◽  
...  
Keyword(s):  
Case Control Study ◽  
Conditional Logistic Regression ◽  
Subsequent Development ◽  
Case Control ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Gi Symptoms ◽  
Nested Case Control ◽  
Incident Cases ◽  
Control Study

ObjectiveDepression is a potential risk factor for developing IBD. This association may be related to GI symptoms occurring before diagnosis. We aimed to determine whether depression, adjusted for pre-existing GI symptoms, is associated with subsequent IBD.DesignWe conducted a nested case–control study using the Clinical Practice Research Datalink identifying incident cases of UC and Crohn’s disease (CD) from 1998 to 2016. Controls without IBD were matched for age and sex. We measured exposure to prevalent depression 4.5–5.5 years before IBD diagnosis. We created two sub-groups with prevalent depression based on whether individuals had reported GI symptoms before the onset of depression. We used conditional logistic regression to derive ORs for the risk of IBD depending on depression status.ResultsWe identified 10 829 UC cases, 4531 CD cases and 15 360 controls. There was an excess of prevalent depression 5 years before IBD diagnosis relative to controls (UC: 3.7% vs 2.7%, CD 3.7% vs 2.9%). Individuals with GI symptoms prior to the diagnosis of depression had increased adjusted risks of developing UC and CD compared with those without depression (UC: OR 1.47, 95% CI 1.21 to 1.79; CD: OR 1.41, 95% CI 1.04 to 1.92). Individuals with depression alone had similar risks of UC and CD to those without depression (UC: OR 1.13, 95% CI 0.99 to 1.29; CD: OR 1.12, 95% CI 0.91 to 1.38).ConclusionsDepression, in the absence of prior GI symptoms, is not associated with subsequent development of IBD. However, depression with GI symptoms should prompt investigation for IBD.

scholarly journals Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink

Rheumatology ◽  
2018 ◽  
Vol 57 (6) ◽  
pp. 1002-1010 ◽  
Author(s):  
Fiona A Pearce ◽  
Peter C Lanyon ◽  
Richard A Watts ◽  
Matthew J Grainge ◽  
Abhishek Abhishek ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Granulomatosis With Polyangiitis ◽  
Case Control Study ◽  
Case Control ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Control Study

scholarly journals Novel insights into the aetiology of granulomatosis with polyangiitis—a case–control study using the Clinical Practice Research Datalink

Rheumatology ◽  
2018 ◽  
Vol 57 (10) ◽  
pp. 1873-1873
Author(s):  
Fiona A Pearce ◽  
Peter C Lanyon ◽  
Richard A Watts ◽  
Matthew J Grainge ◽  
Abhishek Abhishek ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Granulomatosis With Polyangiitis ◽  
Case Control Study ◽  
Case Control ◽  
Practice Research ◽  
Clinical Practice Research Datalink ◽  
Control Study
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