Role of mitochondrial membrane permeabilization and depolarization in platelet apoptosis

2017 ◽  
Vol 181 (2) ◽  
pp. 281-285 ◽  
Author(s):  
Valery Leytin ◽  
Armen V. Gyulkhandanyan ◽  
John Freedman
Keyword(s):  
Mitochondrial Membrane ◽  
Membrane Permeabilization ◽  
Platelet Apoptosis ◽  
Mitochondrial Membrane Permeabilization

scholarly journals Carbon Monoxide Targeting Mitochondria

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Cláudia S. F. Queiroga ◽  
Ana S. Almeida ◽  
Helena L. A. Vieira
Keyword(s):  
Carbon Monoxide ◽  
Cell Death ◽  
Mitochondrial Membrane ◽  
Cell Metabolism ◽  
Membrane Permeabilization ◽  
Biological Functions ◽  
Cellular Target ◽  
Cellular Source ◽  
Mitochondrial Membrane Permeabilization

Mitochondria present two key roles on cellular functioning: (i) cell metabolism, being the main cellular source of energy and (ii) modulation of cell death, by mitochondrial membrane permeabilization. Carbon monoxide (CO) is an endogenously produced gaseoustransmitter, which presents several biological functions and is involved in maintaining cell homeostasis and cytoprotection. Herein, mitochondrion is approached as the main cellular target of carbon monoxide (CO). In this paper, two main perspectives concerning CO modulation of mitochondrial functioning are evaluated. First, the role of CO on cellular metabolism, in particular oxidative phosphorylation, is discussed, namely, on: cytochromecoxidase activity, mitochondrial respiration, oxygen consumption, mitochondrial biogenesis, and general cellular energetic status. Second, the mitochondrial pathways involved in cell death inhibition by CO are assessed, in particular the control of mitochondrial membrane permeabilization.

scholarly journals Role of mitochondrial membrane permeabilization in apoptosis and cancer

Oncogene ◽  
2004 ◽  
Vol 23 (16) ◽  
pp. 2850-2860 ◽  
Author(s):  
Judith Henry-Mowatt ◽  
Caroline Dive ◽  
Jean-Claude Martinou ◽  
Dominic James
Keyword(s):  
Mitochondrial Membrane ◽  
Membrane Permeabilization ◽  
Mitochondrial Membrane Permeabilization

scholarly journals Dynamics of outer mitochondrial membrane permeabilization during apoptosis

2009 ◽  
Vol 16 (4) ◽  
pp. 613-623 ◽  
Author(s):  
M Rehm ◽  
H J Huber ◽  
C T Hellwig ◽  
S Anguissola ◽  
H Dussmann ◽  
...  
Keyword(s):  
Mitochondrial Membrane ◽  
Membrane Permeabilization ◽  
Outer Mitochondrial Membrane ◽  
Mitochondrial Membrane Permeabilization

Involvement of the biogenic active amine agmatine in mitochondrial membrane permeabilization and release of pro-apoptotic factors

Amino Acids ◽  
2019 ◽  
Vol 52 (2) ◽  
pp. 161-169 ◽  
Author(s):  
Pamela Martinis ◽  
Silvia Grancara ◽  
Yuta Kanamori ◽  
Aída Nelly García-Argáez ◽  
Elena Pacella ◽  
...  
Keyword(s):  
Mitochondrial Membrane ◽  
Membrane Permeabilization ◽  
Mitochondrial Membrane Permeabilization ◽  
Apoptotic Factors
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