scholarly journals Analysis of high-resolution human leucocyte antigen allele polymorphism in 3788 Han Chinese patients with leukaemia

2017 ◽  
Vol 181 (2) ◽  
pp. 278-281
Author(s):  
Kuanzhen Liao ◽  
Zhongzheng Zheng ◽  
Lan Yang ◽  
Liping Wang ◽  
Ningjuan Wang ◽  
...  
Keyword(s):  
High Resolution ◽  
Human Leucocyte Antigen ◽  
Han Chinese ◽  
Chinese Patients ◽  
Allele Polymorphism ◽  
Human Leucocyte Antigen Allele

Human leucocyte antigen association of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis with severe ocular complications in Han Chinese

2021 ◽  
pp. bjophthalmol-2020-317105
Author(s):  
Kevin Sheng-Kai Ma ◽  
Wen Hung Chung ◽  
Yi-Jen Hsueh ◽  
Shin-Yi Chen ◽  
Katsushi Tokunaga ◽  
...  
Keyword(s):  
Toxic Epidermal Necrolysis ◽  
Allele Frequency ◽  
Carrier Frequency ◽  
Human Leucocyte Antigen ◽  
Han Chinese ◽  
Chinese Patients ◽  
Stevens Johnson Syndrome ◽  
Ocular Complications ◽  
Hla Polymorphism ◽  
Johnson Syndrome

Background/aimsStevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) induced by cold medicine (CM) may result in severe ocular complications (SOCs). The purpose of this study was to investigate the human leucocyte antigen (HLA) polymorphism pattern in CM-induced patients with SJS/TEN developing SOCs.MethodsAll participants, including patients with SJS/TEN (n=33) and control patients (n=98), were enrolled through visits to the clinic from 2016 to 2017. SOCs were diagnosed (n=26) via a chart review or eye examination. Patient saliva was collected with commercialised kits and genotyped with PCR assays followed by hybridisation with sequence-specific oligonucleotide (SSO) probes (PCR-SSO) using commercial bead-based typing kits.ResultsIn all patients with SJS/TEN with SOCs, the HLA-A*02:07 carrier frequency was significantly higher than that in controls (OR=3.24, 95% CI=1.09 to 9.60, p=0.049), as was the genotype frequency (OR=3.89, 95% CI=1.49 to 10.16, p=0.007). In patients with CM-SJS/TEN with SOCs, the HLA-A*02:07 carrier frequency was higher than that in controls (OR=5.56, 95% CI=1.52 to 20.00, p=0.016), as was the allele frequency (OR=6.67, 95% CI=2.33 to 20.00, p=0.001). In patients with CM-SJS/TEN with SOCs, the HLA-B*46:01 allele frequency was significantly higher than that in controls (OR=3.85, 95% CI=1.52 to 10.00, p=0.008).ConclusionsThe HLA-A*02:07 and HLA-B*46:01 alleles were significantly associated with SOCs among Han Chinese patients with CM-SJS/TEN. These findings demonstrate the genetic diversity in SJS pathogenesis among different ethnic groups.

scholarly journals Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abram Bunya Kamiza ◽  
Wen-Chang Wang ◽  
Jeng-Fu You ◽  
Reiping Tang ◽  
Huei-Tzu Chien ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lynch Syndrome ◽  
Cumulative Risk ◽  
Germline Mutations ◽  
Han Chinese ◽  
Chinese Patients ◽  
Mutation Carriers ◽  
Amsterdam Criteria ◽  
Cumulative Risks ◽  
Age And Sex

AbstractPatients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%–89.9%) and 76.7% (95% CI = 37.2%–99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%–57.7%) and 49.3% (95% CI = 21.9%–84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.

Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis

Allergy ◽  
2010 ◽  
Vol 66 (3) ◽  
pp. 420-427 ◽  
Author(s):  
H. Zhang ◽  
Y. Guo ◽  
W. Wang ◽  
M. Shi ◽  
X. Chen ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Han Chinese ◽  
Chinese Patients

Glycan Biomarkers for Rheumatoid Arthritis and Its Remission Status in Han Chinese Patients

2016 ◽  
Vol 20 (6) ◽  
pp. 343-351 ◽  
Author(s):  
Andrea Sebastian ◽  
Mohamed Ali Alzain ◽  
Collins Otieno Asweto ◽  
Haicheng Song ◽  
Liufu Cui ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Han Chinese ◽  
Chinese Patients ◽  
Remission Status

Leukoaraiosis and NIHSS score help to differentiate subtypes of intracranial branch atheromatous disease in Southern Han Chinese patients with stroke

2013 ◽  
Vol 34 (10) ◽  
pp. 1727-1733 ◽  
Author(s):  
Xuejiao Men ◽  
Aimin Wu ◽  
Bingjun Zhang ◽  
Haiyan Li ◽  
Lei Zhang ◽  
...  
Keyword(s):  
Han Chinese ◽  
Chinese Patients ◽  
Nihss Score ◽  
Branch Atheromatous Disease
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