scholarly journals Diagnostic value of whole-body ultra-low dose computed tomography in comparison with spinal magnetic resonance imaging in the assessment of disease in multiple myeloma

2017 ◽  
Vol 177 (3) ◽  
pp. 395-403 ◽  
Author(s):  
Davide Ippolito ◽  
Cammillo Talei Franzesi ◽  
Sara Spiga ◽  
Valeria Besostri ◽  
Sara Pezzati ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Multiple Myeloma ◽  
Magnetic Resonance ◽  
Low Dose ◽  
Diagnostic Value ◽  
Whole Body ◽  
Resonance Imaging ◽  
Spinal Magnetic Resonance Imaging ◽  
Low Dose Computed Tomography

scholarly journals Whole Body Low Dose Computed Tomography (WBLDCT) Can Be Comparable to Whole-Body Magnetic Resonance Imaging (WBMRI) in the Assessment of Multiple Myeloma

Diagnostics ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 857
Author(s):  
Davide Ippolito ◽  
Teresa Giandola ◽  
Cesare Maino ◽  
Davide Gandola ◽  
Maria Ragusi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Multiple Myeloma ◽  
Magnetic Resonance ◽  
Low Dose ◽  
Whole Body ◽  
Resonance Imaging ◽  
Lesion Number ◽  
Low Dose Computed Tomography ◽  
Ct And Mri

Aim of the study is to compare the agreement between whole-body low-dose computed tomography (WBLDCT) and magnetic resonance imaging (WBMRI) in the evaluation of bone marrow involvement in patients with multiple myeloma (MM). Patients with biopsy-proven MM, who underwent both WBLDCT and WBMRI were retrospectively enrolled. After identifying the presence of focal bone involvement (focal infiltration pattern), the whole skeleton was divided into five anatomic districts (skull, spine, sternum and ribs, pelvis, and limbs). Patients were grouped according to the number and location of the lytic lesions (<5, 5–20, and >20) and Durie and Salmon staging system. The agreement between CT and MRI regarding focal pattern, staging, lesion number, and distribution was assessed using the Cohen Kappa statistics. The majority of patients showed focal involvement. According to the distribution of the focal lesions and Durie Salmon staging, the agreement between CT and MRI was substantial or almost perfect (all κ > 0.60). The agreement increased proportionally with the number of lesions in the pelvis and spine (κ = 0.373 to κ = 0.564, and κ = 0.469–0.624), while for the skull the agreement proportionally decreased without reaching a statistically significant difference (p > 0.05). In conclusion, WBLDCT showed an almost perfect agreement in the evaluation of focal involvement, staging, lesion number, and distribution of bone involvement in comparison with WBMRI.

scholarly journals Imaging in multiple myeloma: How? When?

Blood ◽  
2019 ◽  
Vol 133 (7) ◽  
pp. 644-651 ◽  
Author(s):  
Elena Zamagni ◽  
Paola Tacchetti ◽  
Michele Cavo
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Multiple Myeloma ◽  
Magnetic Resonance ◽  
Imaging Modality ◽  
Response To Therapy ◽  
Whole Body ◽  
Bone Lesions ◽  
Resonance Imaging ◽  
Pet Ct

Abstract Bone disease is the most frequent feature of multiple myeloma (MM) and represents a marker of end-organ damage; it is used to establish the diagnosis and to dictate the immediate need for therapy. For this reason, imaging plays a significant role in the management of MM patients. Although conventional radiography has traditionally been the standard imaging modality, its low sensitivity in detecting osteolytic lesions and inability to evaluate response to therapy has called for the use of more sophisticated techniques, such as whole-body low-dose computed tomography (WBLDCT), whole-body magnetic resonance imaging, and 18F-fluorodeoxyglucose–positron emission tomography/computed tomography (PET/CT). In this review, the advantages, indications of use, and applications of the 3 techniques in the management of patients with MM in different settings will be discussed. The European Myeloma Network and the European Society for Medical Oncology guidelines have recommended WBLDCT as the imaging modality of choice for the initial assessment of MM-related lytic bone lesions. Magnetic resonance imaging is the gold-standard imaging modality for detection of bone marrow involvement, whereas PET/CT provides valuable prognostic data and is the preferred technique for assessment of response to therapy. Standardization of most of the techniques is ongoing.

Diagnostic value of whole-body low-dose computed tomography (WBLDCT) in bone lesions detection in patients with multiple myeloma (MM)

2013 ◽  
Vol 82 (12) ◽  
pp. 2322-2327 ◽  
Author(s):  
Davide Ippolito ◽  
Valeria Besostri ◽  
Pietro Andrea Bonaffini ◽  
Fausto Rossini ◽  
Alessandro Di Lelio ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Multiple Myeloma ◽  
Low Dose ◽  
Diagnostic Value ◽  
Whole Body ◽  
Bone Lesions ◽  
Low Dose Computed Tomography

scholarly journals Emphysema Quantification in Inflation-Fixed Lungs Using Low-Dose Computed Tomography and 3He Magnetic Resonance Imaging

2010 ◽  
Vol 34 (5) ◽  
pp. 773-779 ◽  
Author(s):  
David S. Gierada ◽  
Jason C. Woods ◽  
Richard E. Jacob ◽  
Andrew J. Bierhals ◽  
Cliff K. Choong ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Magnetic Resonance ◽  
Low Dose ◽  
Resonance Imaging ◽  
Low Dose Computed Tomography
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