scholarly journals Maturation-associated gene expression profiles along normal human bone marrow monopoiesis

2017 ◽  
Vol 176 (3) ◽  
pp. 464-474 ◽  
Author(s):  
Fabiana V. Mello ◽  
Liliane R. Alves ◽  
Marcelo G. P. Land ◽  
Cristina Teodósio ◽  
María-Luz Sanchez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Normal Human ◽  
Normal Human Bone Marrow

scholarly journals Maturation-associated gene expression profiles during normal human bone marrow erythropoiesis

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Fabiana V. Mello ◽  
Marcelo G. P. Land ◽  
Elaine. S. Costa ◽  
Cristina Teodósio ◽  
María-Luz Sanchez ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Normal Human ◽  
Normal Human Bone Marrow

scholarly journals TGFβ1-Induced Differentiation of Human Bone Marrow-Derived MSCs Is Mediated by Changes to the Actin Cytoskeleton

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Mona Elsafadi ◽  
Muthurangan Manikandan ◽  
Sami Almalki ◽  
Mohammad Mobarak ◽  
Muhammad Atteya ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Actin Cytoskeleton ◽  
Expression Profiles ◽  
Adipogenic Differentiation ◽  
Gene Expression Profiles ◽  
Cell Types ◽  
Cytochalasin D ◽  
Human Bone ◽  
Human Bone Marrow

TGFβ is a potent regulator of several biological functions in many cell types, but its role in the differentiation of human bone marrow-derived skeletal stem cells (hMSCs) is currently poorly understood. In the present study, we demonstrate that a single dose of TGFβ1 prior to induction of osteogenic or adipogenic differentiation results in increased mineralized matrix or increased numbers of lipid-filled mature adipocytes, respectively. To identify the mechanisms underlying this TGFβ-mediated enhancement of lineage commitment, we compared the gene expression profiles of TGFβ1-treated hMSC cultures using DNA microarrays. In total, 1932 genes were upregulated, and 1298 genes were downregulated. Bioinformatics analysis revealed that TGFβl treatment was associated with an enrichment of genes in the skeletal and extracellular matrix categories and the regulation of the actin cytoskeleton. To investigate further, we examined the actin cytoskeleton following treatment with TGFβ1 and/or cytochalasin D. Interestingly, cytochalasin D treatment of hMSCs enhanced adipogenic differentiation but inhibited osteogenic differentiation. Global gene expression profiling revealed a significant enrichment of pathways related to osteogenesis and adipogenesis and of genes regulated by both TGFβ1 and cytochalasin D. Our study demonstrates that TGFβ1 enhances hMSC commitment to either the osteogenic or adipogenic lineages by reorganizing the actin cytoskeleton.

scholarly journals Microvesicle Induction of Prostate Specific Gene Expression in Normal Human Bone Marrow Cells

2010 ◽  
Vol 184 (5) ◽  
pp. 2165-2171 ◽  
Author(s):  
Joseph F. Renzulli ◽  
Michael Del Tatto ◽  
Gerri Dooner ◽  
Jason Aliotta ◽  
Lisa Goldstein ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Specific Gene ◽  
Specific Gene Expression ◽  
Normal Human ◽  
Normal Human Bone Marrow ◽  
Marrow Cells

FRACTIONATION OF NORMAL HUMAN BONE MARROW ON ALBUMIN GRADIENTS

1974 ◽  
Vol 52 (5) ◽  
pp. 767-778 ◽  
Author(s):  
KA Rickard ◽  
L Dunleavy ◽  
R Brown ◽  
H Kronenberg
Keyword(s):  
Bone Marrow ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Normal Human ◽  
Normal Human Bone Marrow

The effect of vanocomycin and teicoplanin on normal human bone marrow progenitor cells

1992 ◽  
Vol 30 (4) ◽  
pp. 559-560
Author(s):  
R. DE BOCK ◽  
D. VAN BOCKSTAELE ◽  
H. SNOECK ◽  
F. LARDON ◽  
M. PEETERMANS
Keyword(s):  
Bone Marrow ◽  
Progenitor Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Bone Marrow Progenitor Cells ◽  
Bone Marrow Progenitor ◽  
Normal Human ◽  
Normal Human Bone Marrow

Activators and inhibitors of fibrinolysis in normal human bone marrow

1995 ◽  
Vol 6 (2) ◽  
pp. 167
Author(s):  
Nicola A. McWilliam ◽  
Nuala A. Booth ◽  
Linda A. Robbie ◽  
Bruce Bennett
Keyword(s):  
Bone Marrow ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Normal Human ◽  
Normal Human Bone Marrow
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