scholarly journals Increased regulatory T cell graft content is associated with improved outcome in haematopoietic stem cell transplantation: a systematic review

2017 ◽  
Vol 176 (3) ◽  
pp. 448-463 ◽  
Author(s):  
Sheila A. Fisher ◽  
Abigail Lamikanra ◽  
Carolyn Dorée ◽  
Betty Gration ◽  
Pat Tsang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Regulatory T Cell ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
Improved Outcome

scholarly journals Allogeneic haematopoietic stem cell transplantation for the treatment of adult T-cell leukaemia/lymphoma

2003 ◽  
Vol 120 (2) ◽  
pp. 304-309 ◽  
Author(s):  
Masahiro Kami ◽  
Tamae Hamaki ◽  
Shigesaburo Miyakoshi ◽  
Naoko Murashige ◽  
Yoshinobu Kanda ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
Cell Leukaemia

scholarly journals Role of Haematopoietic Stem Cell Transplantation in Peripheral T-Cell Lymphoma

Cancers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 3125
Author(s):  
Chathuri Abeyakoon ◽  
Carrie van der Weyden ◽  
Sean Harrop ◽  
Amit Khot ◽  
Michael Dickinson ◽  
...  
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Haematopoietic Stem Cell ◽  
Phase Ii Studies

Peripheral T-cell lymphomas (PTCLs) are distinct pathological entities with clinical advancements lagging behind their B-cell lymphoma counterpart. Frequently aggressive in their clinical behaviour, clinicians are constantly challenged with low complete remission rates, early relapses and failure to achieve long-term responses despite aggressive first-line chemotherapy, resulting in poor overall survival in the majority of patients. There is currently no consensus regarding the optimal therapy for PTCL and treatment approaches are mainly derived from prospective phase II studies, registry data and retrospective studies. Despite its biological heterogeneity, a less than satisfactory “one-size-fits-all” approach has been adopted to date. Although its role remains controversial, for many years, haematopoietic stem cell transplantation has been adopted by clinicians with the aim of overcoming poor outcomes by consolidating responses. In this review, we aim to define the role of both autologous and allogeneic stem cell transplantation in PTCL in both frontline and salvage settings, especially in the context of recent advancements in this field.

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