scholarly journals Coagulation factor V G1691A, factor II G20210A and methylenetetrahydrofolate reductase C677T gene mutations do not play a major role in symptomatic neonatal arterial ischaemic stroke

2016 ◽  
Vol 180 (2) ◽  
pp. 290-292 ◽  
Author(s):  
Juan Arnaez ◽  
Gemma Arca ◽  
Ana Martín-Ancel ◽  
Alfredo Garcia-Alix
Keyword(s):  
Ischaemic Stroke ◽  
Methylenetetrahydrofolate Reductase ◽  
Gene Mutations ◽  
Coagulation Factor ◽  
Factor V ◽  
Factor Ii ◽  
Factor V G1691a ◽  
Arterial Ischaemic Stroke ◽  
Coagulation Factor V

Identification of three F5 gene mutations associated with inherited coagulation factor V deficiency in two Chinese pedigrees

Haemophilia ◽  
2004 ◽  
Vol 10 (3) ◽  
pp. 264-270 ◽  
Author(s):  
Q.-H. Fu ◽  
R.-F. Zhou ◽  
L.-G. Liu ◽  
W.-B. Wang ◽  
W.-M. Wu ◽  
...  
Keyword(s):  
Gene Mutations ◽  
Coagulation Factor ◽  
Factor V ◽  
Factor V Deficiency ◽  
Coagulation Factor V

scholarly journals Association of Factor II G20210A, Factor V G1691A and methylenetetrahydrofolate reductase C677T gene polymorphism with different forms of myocardial infarction: ST segment elevation and non-ST segment elevation

2020 ◽  
Vol 77 (10) ◽  
pp. 1041-1047
Author(s):  
Milica Cucuz-Jokic ◽  
Vesna Ilic ◽  
Bojana Cikota-Aleksic ◽  
Slobodan Obradovic ◽  
Zvonko Magic
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery ◽  
Methylenetetrahydrofolate Reductase ◽  
Mthfr C677t ◽  
Factor V ◽  
St Segment Elevation ◽  
St Segment ◽  
Factor Ii ◽  
Factor V G1691a ◽  
St Elevation

Background/Aim. Coagulation Factor II G20210A and Factor V G1691A variants are moderately associated with coronary artery disease. Polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene C677T is associated with myocardial infarction (MI) in some ethnical groups. At the present time there are rare studies which try to differentiate two forms of MI, ST-elevation MI (STEMI) and non ST-elevation MI (NSTEMI) according to the genetic background. The aim of the study was investigate the association of polymorphisms of Factor II G20210A, Factor V G1691A and MTHFR C677T with different forms of MI: STEMI and NSTEMI. Methods. The study included 82 patients, divided into two cohorts: patients with STEMI (49 patients) and NSTEMI (33 patients). Genetic factors that would be different in those two entities, included in response to plaque rupture and occlusion of coronary artery, were examined. The peripheral blood lymphocytes were used as DNA source. Genotypes were determined on the polymerase chain reaction (PCR) based methodology. Results. The frequency of MTHFR C677T CT genotype was higher in the patients with NSTEMI in comparison with the patients with STEMI [odds ratio (OR) 3.33; 95% confidence interval (CI) 1.22?9.15; p = 0.02]. Logistic regression analysis shows MTHFR CT genotype as an independent prognostic factor for development of NSTEMI (OR 3.15; 95% CI 1.20?8.29; p = 0.02). There were no differences between two patients groups in frequency of Factor II G20210A and Factor V G1691A gene polymorphism. Conclusion. MTHFR C677T CT genotype was significantly associated with the NSTEMI development examined patients.

Prevalence of coagulation factor II G20210A and factor V G1691A Leiden polymorphisms in Chechans, a genetically isolated population in Jordan

2012 ◽  
Vol 39 (9) ◽  
pp. 9133-9138 ◽  
Author(s):  
Rana Dajani ◽  
Raja Fatahallah ◽  
Abdelrahman Dajani ◽  
Mohammad Al-Shboul ◽  
Yousef Khader
Keyword(s):  
Coagulation Factor ◽  
Factor V ◽  
Isolated Population ◽  
Factor Ii ◽  
Factor V G1691a

scholarly journals The Association of Coagulation Factor V (Leiden) and Factor II (Prothrombin) Mutations with Stroke

2014 ◽  
Vol 16 (11) ◽  
Author(s):  
Maryam Pirhoushiaran ◽  
Mohammad Reza Ghasemi ◽  
Javad Hami ◽  
Peyman Zargari ◽  
Payam Sasan nezhad ◽  
...  
Keyword(s):  
Factor V Leiden ◽  
Coagulation Factor ◽  
Factor V ◽  
Factor Ii ◽  
Coagulation Factor V

Factor II G20210A and Factor V G1691A Gene Mutations and Peripheral Arterial Occlusive Disease

2000 ◽  
Vol 83 (01) ◽  
pp. 20-22 ◽  
Author(s):  
Herwig Köppel ◽  
Marianne Brodmann ◽  
Edmund Pabst ◽  
Katharina Schallmoser ◽  
Hermann Toplak ◽  
...  
Keyword(s):  
Peripheral Arterial Occlusive Disease ◽  
Gene Mutations ◽  
Arterial Occlusive Disease ◽  
Occlusive Disease ◽  
Factor V ◽  
Factor Ii ◽  
Factor V G1691a ◽  
Factor V Gene ◽  
Prothrombin Gene ◽  
Peripheral Arterial

SummaryG to A mutations at positions 20210 of the prothrombin gene (F2) and 1691 of the factor V gene (F5) are established risk factors for venous thrombosis. Several factors associated with coagulation and/or fibrinolysis have been associated with arterial occlusive disease, but the role of F2 20210A and F5 1691A for arterial occlusive disease remains unclear.To investigate if F2 20210A and F5 1691A are associated with peripheral arterial occlusive disease (PAOD).We analyzed the prevalence of F2 20210A and F5 1691A alleles in 336 patients with documented PAOD at Fontaine stage II – IV and 300 controls without vascular disease. Allele frequencies in patients and controls were 0.013 and 0.022 for F2 20210A, and 0.042 and 0.045 for F5 1691, respectively, both differences being not statistically significant.Our data suggest that mutations F2 G20210A and F5 G1691A are not associated with PAOD.

Coagulation Factor V Leiden Mutation Was Detected in the Patients with Activated Protein C Resistance in Thailand

1998 ◽  
Vol 80 (08) ◽  
pp. 344-345 ◽  
Author(s):  
Pasra Arnutti ◽  
Motofumi Hiyoshi ◽  
Wichai Prayoonwiwat ◽  
Oytip Nathalang ◽  
Chamaiporn Suwanasophon ◽  
...  
Keyword(s):  
Protein C ◽  
Activated Protein C ◽  
Factor V Leiden ◽  
Coagulation Factor ◽  
Factor V ◽  
Activated Protein C Resistance ◽  
Factor V Leiden Mutation ◽  
Coagulation Factor V
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