scholarly journals Residual disease detected by flow cytometry is an independent predictor of survival in childhood acute myeloid leukaemia; results of the NOPHO-AML 2004 study

2016 ◽  
Vol 174 (4) ◽  
pp. 600-609 ◽  
Author(s):  
Anne Tierens ◽  
Elizabeth Bjørklund ◽  
Sanna Siitonen ◽  
Hanne Vibeke Marquart ◽  
Gitte Wulff -Juergensen ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Residual Disease ◽  
Independent Predictor ◽  
Acute Myeloid

Minimal residual disease evaluation by flow cytometry is a complementary tool to cytogenetics for treatment decisions in acute myeloid leukaemia

2016 ◽  
Vol 40 ◽  
pp. 1-9 ◽  
Author(s):  
María-Belén Vidriales ◽  
Estefanía Pérez-López ◽  
Carlota Pegenaute ◽  
Marta Castellanos ◽  
José-Juan Pérez ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Minimal Residual Disease ◽  
Residual Disease ◽  
Treatment Decisions ◽  
Minimal Residual ◽  
Acute Myeloid

Aberrant Expression of CD Markers in Acute Myeloid Leukaemia

2018 ◽  
Vol 2 (01) ◽  
pp. 14-16
Author(s):  
Abul Kalam Azad ◽  
Md. Rafiquzzaman Khan ◽  
ABM Hasan Habib ◽  
Md. Abdul Wadud Miah ◽  
Masuda Begum
Keyword(s):  
Flow Cytometry ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Acute Leukaemia ◽  
Antigen Expression ◽  
Aberrant Expression ◽  
Female Ratio ◽  
Cd Antigen ◽  
Cd Markers ◽  
Acute Myeloid

Background: Aberrant expression of cluster differentiation (CD) antigen marker is associated with poor outcome of acute leukaemia. Objective: Aim of this study is to determine the frequency and pattern of aberrant expression of CD markers in acute myeloid leukaemia patients in Bangladesh. Methods: This retrospective data analysis was conducted in the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) to assess the frequency of aberrant CD antigen expression in acute myeloid leukaemia from October 2016 to September 2017. During this period, we did one hundred flow cytometry of acute leukaemia patients and among them we found 48 acute myeloid Leukaemia (AML) who were included in this study. Result: Mean age of patients was 35 years (SD­ +14 years; Rang 3 to 50 years) with male: female ratio of 0.92. Four colour flow cytometry was done on fresh bone marrow aspirates and peripheral blood. Among 48 AML patients, aberrant CD expression was observed in 58% cases.  CD5 and cCD79a lymphoid markers were seen to be expressed in 32% cases of AML. Aberrant cCD3 and CD7 were expressed in 29% and 25% cases respectively and aberrant CD10, CD19, cCD22 were expressed in 11%, 3%, 3% cases acute myeloid leukaemia patients respectively. Conclusion: Aberrant CD antigen expression is not uncommon in AML patients of Bangladeshi population that may adversely affect the treatment outcome of the disease.

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