scholarly journals Minimal residual disease assessed by multi-parameter flow cytometry is highly prognostic in adult patients with acute lymphoblastic leukaemia

2015 ◽  
Vol 172 (3) ◽  
pp. 392-400 ◽  
Author(s):  
Farhad Ravandi ◽  
Jeffrey L. Jorgensen ◽  
Susan M. O'Brien ◽  
Elias Jabbour ◽  
Deborah A. Thomas ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Residual Disease ◽  
Adult Patients ◽  
Minimal Residual

scholarly journals Detection of minimal residual disease in B-lineage acute lymphoblastic leukaemia by quantitative flow cytometry

1998 ◽  
Vol 101 (1) ◽  
pp. 158-164 ◽  
Author(s):  
Nahla Farahat ◽  
Alison Morilla ◽  
Kwasi Owusu-Ankomah ◽  
Ricardo Morilla ◽  
C. Ross Pinkerton ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Residual Disease ◽  
B Lineage ◽  
Minimal Residual ◽  
Quantitative Flow

Flow cytometric minimal residual disease assessment of peripheral blood in acute lymphoblastic leukaemia patients has potential for early detection of relapsed extramedullary disease

2018 ◽  
Vol 71 (7) ◽  
pp. 653-658 ◽  
Author(s):  
Alissa Keegan ◽  
Karry Charest ◽  
Ryan Schmidt ◽  
Debra Briggs ◽  
Daniel J Deangelo ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukaemia ◽  
Minimal Residual Disease ◽  
Lymphoblastic Leukaemia ◽  
Peripheral Blood ◽  
Residual Disease ◽  
Diagnostic Value ◽  
Disease Assessment ◽  
Extramedullary Disease ◽  
Systemic Relapse ◽  
Minimal Residual

ObjectivesTo evaluate peripheral blood (PB) for minimal residual disease (MRD) assessment in adults with acute lymphoblastic leukaemia (ALL).MethodsWe analysed 76 matched bone marrow (BM) aspirate and PB specimens independently for the presence of ALL MRD by six-colour flow cytometry (FC).ResultsThe overall rate of BM MRD-positivity was 24% (18/76) and PB was also MRD-positive in 22% (4/18) of BM-positive cases. We identified two cases with evidence of leukaemic cells in PB at the time of the extramedullary relapse that were interpreted as MRD-negative in BM.ConclusionsThe use of PB MRD as a non-invasive method for monitoring of systemic relapse may have added clinical and diagnostic value in patients with high risk of extramedullary disease.

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