scholarly journals Myeloma impairs mature osteoblast function but causes early expansion of osteo-progenitors: temporal changes in bone physiology and gene expression in the KMS12BM model

2015 ◽  
Vol 172 (1) ◽  
pp. 64-79 ◽  
Author(s):  
Deepika Kassen ◽  
Darren Lath ◽  
Anna Lach ◽  
Holly Evans ◽  
Andy Chantry ◽  
...  
Keyword(s):  
Gene Expression ◽  
Temporal Changes ◽  
Osteoblast Function ◽  
Mature Osteoblast ◽  
Bone Physiology

scholarly journals Temporal changes in DNA methylation and RNA expression in a small song bird: within- and between-tissue comparisons

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Melanie Lindner ◽  
Irene Verhagen ◽  
Heidi M. Viitaniemi ◽  
Veronika N. Laine ◽  
Marcel E. Visser ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Methylation ◽  
Environmental Conditions ◽  
Brain Regions ◽  
Temporal Changes ◽  
Egg Laying ◽  
Gene Body ◽  
Cpg Site ◽  
Repeated Sampling ◽  
Over Time

Abstract Background DNA methylation is likely a key mechanism regulating changes in gene transcription in traits that show temporal fluctuations in response to environmental conditions. To understand the transcriptional role of DNA methylation we need simultaneous within-individual assessment of methylation changes and gene expression changes over time. Within-individual repeated sampling of tissues, which are essential for trait expression is, however, unfeasible (e.g. specific brain regions, liver and ovary for reproductive timing). Here, we explore to what extend between-individual changes in DNA methylation in a tissue accessible for repeated sampling (red blood cells (RBCs)) reflect such patterns in a tissue unavailable for repeated sampling (liver) and how these DNA methylation patterns are associated with gene expression in such inaccessible tissues (hypothalamus, ovary and liver). For this, 18 great tit (Parus major) females were sacrificed at three time points (n = 6 per time point) throughout the pre-laying and egg-laying period and their blood, hypothalamus, ovary and liver were sampled. Results We simultaneously assessed DNA methylation changes (via reduced representation bisulfite sequencing) and changes in gene expression (via RNA-seq and qPCR) over time. In general, we found a positive correlation between changes in CpG site methylation in RBCs and liver across timepoints. For CpG sites in close proximity to the transcription start site, an increase in RBC methylation over time was associated with a decrease in the expression of the associated gene in the ovary. In contrast, no such association with gene expression was found for CpG site methylation within the gene body or the 10 kb up- and downstream regions adjacent to the gene body. Conclusion Temporal changes in DNA methylation are largely tissue-general, indicating that changes in RBC methylation can reflect changes in DNA methylation in other, often less accessible, tissues such as the liver in our case. However, associations between temporal changes in DNA methylation with changes in gene expression are mostly tissue- and genomic location-dependent. The observation that temporal changes in DNA methylation within RBCs can relate to changes in gene expression in less accessible tissues is important for a better understanding of how environmental conditions shape traits that temporally change in expression in wild populations.

Temporal changes in regeneration-associated gene expression in cryopreserved rat vascular grafts

2003 ◽  
Vol 35 (1) ◽  
pp. 506-508
Author(s):  
T Kiji ◽  
Y Dohi ◽  
K Nishizaki ◽  
H Sakaguchi ◽  
S Nagasaka ◽  
...  
Keyword(s):  
Gene Expression ◽  
Vascular Grafts ◽  
Temporal Changes

scholarly journals Temporal changes in the gene expression heterogeneity during brain development and aging

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Ulaş Işıldak ◽  
Mehmet Somel ◽  
Janet M. Thornton ◽  
Handan Melike Dönertaş
Keyword(s):  
Gene Expression ◽  
Brain Development ◽  
Temporal Changes ◽  
Gene Expression Heterogeneity ◽  
Development And Aging

scholarly journals Temporal changes in mouse aortic wall gene expression during the development of elastase-induced abdominal aortic aneurysms

2006 ◽  
Vol 43 (5) ◽  
pp. 1010-1020 ◽  
Author(s):  
Sarah J. Van Vickle-Chavez ◽  
William S. Tung ◽  
Tarek S. Absi ◽  
Terri L. Ennis ◽  
Dongli Mao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Aortic Wall ◽  
Abdominal Aortic Aneurysms ◽  
Temporal Changes ◽  
Aortic Aneurysms ◽  
Abdominal Aortic

scholarly journals Temporal Changes in Gene Expression after Injury in the Rat Retina

2004 ◽  
Vol 45 (8) ◽  
pp. 2737 ◽  
Author(s):  
Fe´lix Va´zquez-Chona ◽  
Bong K. Song ◽  
Eldon E. Geisert
Keyword(s):  
Gene Expression ◽  
Temporal Changes ◽  
Rat Retina

Temporal changes in gene expression following cryogenic rat brain injury

1998 ◽  
Vol 55 (1) ◽  
pp. 9-19 ◽  
Author(s):  
Julia L. Cook ◽  
Victor Marcheselli ◽  
Jawed Alam ◽  
Prescott L. Deininger ◽  
Nicolas G. Bazan
Keyword(s):  
Gene Expression ◽  
Brain Injury ◽  
Rat Brain ◽  
Temporal Changes
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