scholarly journals Brefeldin A exerts differential effects on anaplastic lymphoma kinase positive anaplastic large cell lymphoma and classical Hodgkin lymphoma cell lines

2015 ◽  
Vol 170 (6) ◽  
pp. 837-846 ◽  
Author(s):  
Takashi Toda ◽  
Mariko Watanabe ◽  
Junji Kawato ◽  
Marshall E. Kadin ◽  
Masaaki Higashihara ◽  
...  
Keyword(s):  
Hodgkin Lymphoma ◽  
Anaplastic Large Cell Lymphoma ◽  
Anaplastic Lymphoma Kinase ◽  
Cell Lymphoma ◽  
Brefeldin A ◽  
Large Cell ◽  
Classical Hodgkin Lymphoma ◽  
Anaplastic Lymphoma ◽  
Hodgkin Lymphoma Cell ◽  
Large Cell Lymphoma

scholarly journals Usefulness of BATF3 Immunohistochemistry in Diagnosing Classical Hodgkin Lymphoma

Diagnostics ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1123
Author(s):  
Julian Benckendorff ◽  
Johanna Kuchar ◽  
Frank Leithäuser ◽  
Malena Zahn ◽  
Peter Möller
Keyword(s):  
Transcription Factor ◽  
Western Blot ◽  
Hodgkin Lymphoma ◽  
Anaplastic Large Cell Lymphoma ◽  
Diagnostic Marker ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Classical Hodgkin Lymphoma ◽  
Highly Sensitive ◽  
Large Cell Lymphoma

It is well recognized that the AP-1 transcription factor BATF3 is constitutively expressed in Hodgkin/Reed-Sternberg (HRS) cells, but its potential as a diagnostic marker for classical Hodgkin lymphoma (cHL) has not yet been addressed. In this study, we performed immunohistochemistry and analyzed the BATF3 expression in lymphoma cells on 218 lymphoma samples belonging to 14 different lymphoma entities. We observed varying degrees of BATF3 expression in nearly half of the cases (n = 100) with BATF3 expression being a constitutive feature of cHL (n = 53) and anaplastic large cell lymphoma (ALCL). By scoring BATF3 expression (BATF3-score) we observed constitutively high BATF3-scores in cHL and ALCL and low to moderate BATF3-scores in all other entities examined. Western blot analysis confirmed BATF3 protein expression in cell lysates from cHL cell lines (n = 7). Thus, BATF3 can be considered a useful IHC marker for the diagnosis of cHL as it is highly sensitive and sufficiently specific when analyzed by BATF3-scoring.

Primary Anaplastic Lymphoma Kinase–Negative Anaplastic Large Cell Lymphoma of the Brain in a Patient With Acquired Immunodeficiency Syndrome

2004 ◽  
Vol 128 (3) ◽  
pp. 324-327
Author(s):  
Edward H. Rowsell ◽  
Nazila Zekry ◽  
Boleslaw H. Liwnicz ◽  
Jeffrey D. Cao ◽  
Qin Huang ◽  
...  
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Acquired Immunodeficiency Syndrome ◽  
Anaplastic Lymphoma Kinase ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Anaplastic Lymphoma ◽  
Acquired Immunodeficiency ◽  
Large Cell Lymphoma ◽  
Immunodeficiency Syndrome ◽  
The Brain

Abstract Anaplastic large cell lymphoma is a unique diagnostic subcategory of the T-cell lymphomas in the current World Health Organization classification. Representing approximately 3% of adult and 10% to 30% of childhood non-Hodgkin lymphomas, anaplastic large cell lymphoma classically consists of CD30+ large lymphoid cells with abundant cytoplasm and pleomorphic, often horseshoe-shaped or kidney-shaped nuclei. Among the reported nodal and extranodal sites of occurrence, the gastrointestinal tract and central nervous system have rarely been noted. We report a case of primary anaplastic lymphoma kinase–negative anaplastic large cell lymphoma in the brain of a 46-year-old patient with acquired immunodeficiency syndrome. T-cell lineage was confirmed by T-cell receptor γ chain gene rearrangements using polymerase chain reaction, and extra copies of the anaplastic lymphoma kinase gene of chromosome 2 were demonstrated by fluorescence in situ hybridization analysis. To our knowledge, primary anaplastic large cell lymphoma of the brain has not previously been reported in acquired immunodeficiency syndrome.

The Small Cell Variant of Anaplastic Large Cell Lymphoma

2010 ◽  
Vol 134 (11) ◽  
pp. 1706-1710 ◽  
Author(s):  
Thomas A. Summers ◽  
Joel T. Moncur
Keyword(s):  
Anaplastic Large Cell Lymphoma ◽  
Anaplastic Lymphoma Kinase ◽  
Cell Lymphoma ◽  
Large Cell ◽  
Short Review ◽  
Small Cell ◽  
Anaplastic Lymphoma ◽  
Small Cell Variant ◽  
Large Cell Lymphoma ◽  
Cell Variant

Abstract Anaplastic large cell lymphomas constitute a heterogeneous group of hematopoietic neoplasms that are characterized by immunopositivity for CD30 and the presence, in varying degrees, of large, pleomorphic “hallmark” cells. Primary systemic anaplastic lymphoma kinase-positive anaplastic large cell lymphomas are a subset of this group. Numerous heterogeneous histomorphologic patterns have been described in anaplastic lymphoma kinase-positive anaplastic large cell lymphomas, and all patterns tend to have a better prognosis than that found in anaplastic lymphoma kinase-negative cases. We provide a short review of the small cell variant of anaplastic large cell lymphoma to facilitate the diagnosis of this difficult-to-recognize entity, which may be confused with reactive processes, commonly presents with disseminated disease, and pursues an aggressive clinical course.

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