Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia

2015 ◽  
Vol 172 (1) ◽  
pp. 131-134 ◽  
Author(s):  
Yoko Inaguma ◽  
Yoshiki Akatsuka ◽  
Kohei Hosokawa ◽  
Hiroyuki Maruyama ◽  
Akinao Okamoto ◽  
...  
Keyword(s):  
T Cells ◽  
Progenitor Cells ◽  
Aplastic Anaemia ◽  
Severe Aplastic Anaemia

scholarly journals Transplantation of highly purified CD34+ progenitor cells from alternative donors in children with refractory severe aplastic anaemia

2004 ◽  
Vol 125 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Martin Benesch ◽  
Christian Urban ◽  
Karl W. Sykora ◽  
Wolfgang Schwinger ◽  
Felix Zintl ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Aplastic Anaemia ◽  
Severe Aplastic Anaemia

scholarly journals Eltrombopag added to immunosuppression for children with treatment‐naïve severe aplastic anaemia

2021 ◽  
Author(s):  
Emma M. Groarke ◽  
Bhavisha A. Patel ◽  
Fernanda Gutierrez‐Rodrigues ◽  
Olga Rios ◽  
Jennifer Lotter ◽  
...  
Keyword(s):  
Aplastic Anaemia ◽  
Severe Aplastic Anaemia ◽  
Treatment Naïve

scholarly journals COVID‐19 infection in patients with severe aplastic anaemia

2021 ◽  
Author(s):  
Casey Paton ◽  
Liza Mathews ◽  
Emma M. Groarke ◽  
Olga Rios ◽  
Jennifer Lotter ◽  
...  
Keyword(s):  
Aplastic Anaemia ◽  
Severe Aplastic Anaemia

scholarly journals Adult Renal Stem/Progenitor Cells Can Modulate T Regulatory Cells and Double Negative T Cells

2020 ◽  
Vol 22 (1) ◽  
pp. 274
Author(s):  
Claudia Curci ◽  
Angela Picerno ◽  
Nada Chaoul ◽  
Alessandra Stasi ◽  
Giuseppe De Palma ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Progenitor Cells ◽  
Mononuclear Cells ◽  
Human Peripheral Blood ◽  
Double Negative ◽  
Chronic Injury ◽  
Peripheral Blood Mononuclear ◽  
Cell Subpopulations ◽  
T Cell Subpopulations

Adult Renal Stem/Progenitor Cells (ARPCs) have been recently identified in the human kidney and several studies show their active role in kidney repair processes during acute or chronic injury. However, little is known about their immunomodulatory properties and their capacity to regulate specific T cell subpopulations. We co-cultured ARPCs activated by triggering Toll-Like Receptor 2 (TLR2) with human peripheral blood mononuclear cells for 5 days and 15 days and studied their immunomodulatory capacity on T cell subpopulations. We found that activated-ARPCs were able to decrease T cell proliferation but did not affect CD8+ and CD4+ T cells. Instead, Tregs and CD3+ CD4- CD8- double-negative (DN) T cells decreased after 5 days and increased after 15 days of co-culture. In addition, we found that PAI1, MCP1, GM-CSF, and CXCL1 were significantly expressed by TLR2-activated ARPCs alone and were up-regulated in T cells co-cultured with activated ARPCs. The exogenous cocktail of cytokines was able to reproduce the immunomodulatory effects of the co-culture with activated ARPCs. These data showed that ARPCs can regulate immune response by inducing Tregs and DN T cells cell modulation, which are involved in the balance between immune tolerance and autoimmunity.

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