scholarly journals Real world data on acute myeloid leukaemia therapy from the developing world - an eye-opener

2015 ◽  
Vol 170 (1) ◽  
pp. 1-2 ◽  
Author(s):  
Peter Hokland ◽  
Finbarr Cotter
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Real World ◽  
Developing World ◽  
Real World Data ◽  
World Data ◽  
Leukaemia Therapy ◽  
Acute Myeloid

scholarly journals Acute myeloid leukaemia: challenges and real world data from India

2015 ◽  
Vol 170 (1) ◽  
pp. 110-117 ◽  
Author(s):  
Chepsy Philip ◽  
Biju George ◽  
Abhijeet Ganapule ◽  
Anu Korula ◽  
Punit Jain ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Real World ◽  
Real World Data ◽  
World Data ◽  
Acute Myeloid

The use of nanocarriers in acute myeloid leukaemia therapy: challenges and current status.

2015 ◽  
Vol 17 (1) ◽  
pp. 30-41 ◽  
Author(s):  
Félix Sauvage ◽  
Gillian Barratt ◽  
Lars Herfindal ◽  
Juliette Vergnaud-Gauduchon
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Current Status ◽  
Leukaemia Therapy ◽  
Acute Myeloid

scholarly journals Beneficial role of increased FOXP3+ regulatory T-cells in acute myeloid leukaemia therapy response

2017 ◽  
Vol 182 (4) ◽  
pp. 581-583 ◽  
Author(s):  
Thomas Menter ◽  
Boris Kuzmanic ◽  
Christoph Bucher ◽  
Michael Medinger ◽  
Joerg Halter ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Therapy Response ◽  
Beneficial Role ◽  
Leukaemia Therapy ◽  
Acute Myeloid

scholarly journals Endothelial E-selectin inhibition improves acute myeloid leukaemia therapy by disrupting vascular niche-mediated chemoresistance

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Valerie Barbier ◽  
Johanna Erbani ◽  
Corrine Fiveash ◽  
Julie M. Davies ◽  
Joshua Tay ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Vascular Niche ◽  
Leukaemia Therapy ◽  
Acute Myeloid

Efficacy and feasibility of intensive induction therapy in very elderly patients with acute myeloid leukaemia

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 16528-16528
Author(s):  
G. Biaggi ◽  
A. Santagostino ◽  
D. Manachino ◽  
T. Posca ◽  
G. Forti ◽  
...  
Keyword(s):  
Elderly Patients ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Performance Status ◽  
Best Supportive Care ◽  
Induction Treatment ◽  
Very Elderly ◽  
Ecog Performance Status ◽  
Leukaemia Therapy ◽  
Acute Myeloid

16528 Background: Intensive Induction Treatment (IIT) increases chances of longer survival in acute myeloid leukaemia (AML). Our aim was to improve outcome and to evaluate safety and tolerability of IIT in very elderly patients (pts). Otherwise they have a median surviving time of 11 weeks without treatment. Methods: From October 2003 to November 2005 we treated 23 pts, 16 Males (M) and 7 Female (F); median age 75.5 years (range 68–95). According FAB classification they were 1 M0, 10 M1, 5 M2, 6 M4, 1 M5. ECOG performance status (PS) was 0 in 6 pts, 1 in 5 pts, 2 in 7 pts and 3 in 5 pts. All pts underwent IIT with different schedules: only a female 95 years old had less intensive treatment. Immune-chemotherapy was also admitted. Schedules were: 3+7 IDA+ARA-C in 8 pts; MY-FLAI in 7 pts; VP+ARA-C 1 = ≥ 5 in 2 pts; IDA+ARA-C 1 = ≥ 2 in 4 pts; ARA-C + 6TG in 1 pt. Eleven pts underwent second line treatment. Results: Five pts are alive and 18 dead. We obtained 7 complete responses (CR) (32%) and 1 partial response (PR) (RR 36%);. The median CR duration was 7.5 months (range 1–12).Throughout IIT we observed 5 toxic deaths (23%) because of infections and 2 deaths not leukaemia therapy related (heart failure). The median Overall Survival (OS) was 9 months. Conclusions: Despite the toxic deaths due to the treatment, we obtained in 32% of the pts CR longer compared to palliative or best supportive care; also the median OS was longer than we can expected without chemotherapy. Our data support in our opinion the feasibility and the utility of an IIT in very elderly patients with good PS. No significant financial relationships to disclose.

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