scholarly journals Pregnancy outcome in patients with sickle cell disease in the UK - a national cohort study comparing sickle cell anaemia (HbSS) with HbSC disease

2014 ◽  
Vol 169 (1) ◽  
pp. 129-137 ◽  
Author(s):  
Eugene Oteng-Ntim ◽  
Benjamin Ayensah ◽  
Marian Knight ◽  
Jo Howard
Keyword(s):  
Cohort Study ◽  
Sickle Cell Disease ◽  
Pregnancy Outcome ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cell Disease ◽  
National Cohort ◽  
The Uk

scholarly journals Pregnancy outcomes in sickle cell disease: a retrospective cohort study from two tertiary centres in the UK

2010 ◽  
Vol 3 (3) ◽  
pp. 110-112 ◽  
Author(s):  
A R Chase ◽  
M Sohal ◽  
J Howard ◽  
R Laher ◽  
A McCarthy ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Retrospective Cohort Study ◽  
Pregnancy Outcomes ◽  
Retrospective Cohort ◽  
Historical Data ◽  
Cell Disease ◽  
The Uk ◽  
Singleton Pregnancies

The objective of this retrospective cohort study from two tertiary centres in the UK was to describe the pregnancy outcomes of women with sickle cell disease (SCD) who booked at these centres between 2004 and 2008, and to compare this with historical data. The study population comprised 122 singleton pregnancies in women with SCD: homozygous sickle cell disease 64, sickle cell haemoglobin C disease 45, sickle b plus thalassaemia 11, sickle cell haemoglobin E disease 1 and sickle cell delta disease 1 from 2004 to 2008 managed in the joint haematology/obstetric antenatal clinics in two tertiary teaching hospitals. The main outcome measures were the frequency of sickle cell crises and obstetric complications. Age and gestation at booking were 18–43 years (mean 29.7) and 9–36 weeks gestation (mean 17.3), respectively. Complications of SCD occurred in 25% of pregnancies. Fifty-four percent of women had induction of labour and 39% were delivered by emergency caesarean section. Thirty-three percent had a postpartum haemorrhage. Nineteen percent of women delivered before 37 completed weeks. Birth weight below 2500 g occurred in 20% of singleton pregnancies. Three neonates developed transient complications related to maternal opiate exposure postnatally. Three intrauterine deaths occurred at 24, 29 and 34 weeks. Two of these had congenital defects, and the other severe intrauterine growth restriction. No maternal deaths occurred. Successful pregnancy outcomes can be achieved in SCD. There has been an improvement in fetal and maternal morbidity and mortality compared with historical data. Pregnancy in women with SCD remains high risk. Early access to antenatal care and to expertise in SCD is essential. A matched control population from the same time period and prospective data collection is needed to address confounders such as ethnicity and deprivation.

Sickle cell disease

2016 ◽  
Vol 10 (2) ◽  
pp. 73-81 ◽  
Author(s):  
Anietie Ekong
Keyword(s):  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Cell Disease ◽  
Chronic Complications ◽  
Health Maintenance ◽  
Abnormal Haemoglobin ◽  
The Uk ◽  
The Tropics ◽  
Cell Gene

The haemoglobinopathies are the most common monogenetic diseases in the world. They include the thalassaemias and sickle cell syndromes. The sickle cell syndromes encompass several abnormal haemoglobin variants, of which homozygosity for the sickle cell gene – that is, sickle cell anaemia is the most common and most severe. Originally characteristic of the tropics and subtropics, recent mobility and migratory trends have meant that the prevalence of sickle cell disease (SCD) has significantly increased in the UK. It is important that GPs have an understanding of this disease, in order to help their patients deal with complications of every-day life. This article will address three main aspects of SCD: diagnosis, health maintenance, and some acute and chronic complications of SCD.

Retrospective Cohort Study Comparing the Effect of Obesity in Children with Sickle Cell Disease

PEDIATRICS ◽  
2016 ◽  
Vol 137 (Supplement 3) ◽  
pp. 264A-264A
Author(s):  
Parth J. Bhatt ◽  
Dinesh Singh ◽  
Akingbola Olubenga ◽  
Devraj Chavda ◽  
Achint Patel
Keyword(s):  
Cohort Study ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Cell Disease ◽  
Obesity In Children

scholarly journals Morbidity and mortality of sickle cell disease patients starting intermittent haemodialysis: a comparative cohort study with non- Sickle dialysis patients

2016 ◽  
Vol 174 (1) ◽  
pp. 148-152 ◽  
Author(s):  
Louise Nielsen ◽  
Florence Canouï-Poitrine ◽  
Jean-Philippe Jais ◽  
Djamal Dahmane ◽  
Pablo Bartolucci ◽  
...  
Keyword(s):  
Cohort Study ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Morbidity And Mortality ◽  
Cell Disease ◽  
Dialysis Patients ◽  
Intermittent Haemodialysis ◽  
Comparative Cohort Study

scholarly journals Improved survival in homozygous sickle cell disease: lessons from a cohort study

BMJ ◽  
1995 ◽  
Vol 311 (7020) ◽  
pp. 1600-1602 ◽  
Author(s):  
A. Lee ◽  
P. Thomas ◽  
L. Cupidore ◽  
B. Serjeant ◽  
G. Serjeant
Keyword(s):  
Cohort Study ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Cell Disease ◽  
Homozygous Sickle Cell Disease
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