scholarly journals Non-anaplastic peripheral T-cell lymphoma in children and adolescents - a retrospective analysis of the NHL-BFM study group

2014 ◽  
Vol 168 (6) ◽  
pp. 835-844 ◽  
Author(s):  
Udo Kontny ◽  
Ilske Oschlies ◽  
Willi Woessmann ◽  
Birgit Burkhardt ◽  
Jasmin Lisfeld ◽  
...  
Keyword(s):  
T Cell ◽  
Children And Adolescents ◽  
Retrospective Analysis ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Study Group ◽  
Peripheral T Cell Lymphoma

scholarly journals Bone marrow transplantation for peripheral T-cell lymphoma in children and adolescents

Blood ◽  
1992 ◽  
Vol 80 (11) ◽  
pp. 2938-2942 ◽  
Author(s):  
BG Gordon ◽  
PI Warkentin ◽  
DD Weisenburger ◽  
JM Vose ◽  
WG Sanger ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
T Cell ◽  
Phase I ◽  
Children And Adolescents ◽  
Marrow Transplantation ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
The Other ◽  
Peripheral T Cell Lymphoma

Abstract We report nine children with relapsed (n = 8) or high-risk (n = 1) peripheral T-cell lymphoma (PTCL) who underwent autologous (n = 6) or allogeneic (n = 3) bone marrow transplantation (BMT). These children received transplants as part of a prospective phase I/II study of thioTEPA (TT) and total body irradiation (TBI) with escalating doses of VP-16. The median age of these patients at time of BMT was 6.5 years (range 2.5 years to 14 years). Three were transplanted with active disease after failing salvage chemotherapy. Of the other six, one was transplanted in first complete remission (CR) and five in second or subsequent CR. Of these nine patients, eight are free of disease a median of 25 months after BMT (range, 6 to 48 months), with an estimated 2-year relapse-free survival (RFS) of 89%. Six of these eight patients have been followed for 12 or more months after BMT, and in each their current remission exceeds their longest previous remission duration. The toxicity of the TT/TBI +/- VP-16 regimens was significant but manageable, predominantly consisting of severe mucositis. For a comparison, we reviewed retrospective data on the six additional children and adolescents with PTCL who underwent BMT during the 3-year period preceding this phase I/II study. The median age at BMT of these six patients was 19 years (range 15.5 years to 20 years). These patients were prepared for BMT with a variety of other regimens. One had no response to BMT and the other five relapsed at 1.5 to 5 months after BMT (median, 3 months) with an RFS of 0%. Our data suggest that thioTEPA plus TBI, with or without VP-16, is an effective preparative regimen for BMT for young patients with relapsed or high-stage PTCL and leads to prolonged RFS.

Autologous stem cell transplant in peripheral T cell lymphomas: Single institution 10-year retrospective analysis

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e19538-e19538
Author(s):  
C. E. Vigil ◽  
E. Ayala ◽  
L. Sokol
Keyword(s):  
Stem Cell ◽  
T Cell ◽  
Retrospective Analysis ◽  
Stem Cell Transplant ◽  
Cell Lymphoma ◽  
Disease Status ◽  
Autologous Stem Cell Transplant ◽  
T Cell Lymphoma ◽  
Cell Transplant ◽  
Peripheral T Cell Lymphoma

e19538 Background: Peripheral T-cell lymphoma is a rare entitydisease, compromising 10% of non-Hodgkin's lymphoma worldwide and 5% of all lymphoid neoplasms in the United States. The long-term survival of conventional therapies has led the exploration of alternatives. High-dose chemotherapy followed by autologous haematopoietic stem cell transplantation, has been explored in recent years with little experiences. We are reporting our single-institute data in this population. Methods: A retrospective analysis on patients with diagnosis of peripheral T-cell lymphoma receiving autologous stem cell transplant was conducted (January 1997 to July 2008). The patients were stratified according to their International Prognostic Index (IPI), disease status at the time of transplant and histology type. Results: Twenty-nine subjects were identified, with a median age of 51; 13 patients had Anaplastic T cell, 18 patient had PTCL-nos, and 6 patients with angioimmunoblastic T cell lymphoma. Seventeen patients (58.62%) presented with an aa IPI score greater than 2.4 patients were in complete remission, 15 at first relapse, 4 in greater than 1 episode, and 6 with refractory disease at the time of transplantion.Kaplan Meier overall survival (OS) 72 and relapse free survival (RFS) was 62 at 1 year respectively. A multivariate analysis and new risk stratification based on the IPI score system and disease status at time of transplant were employed. We found that the lower risk category demonstrated a higher likelihood of longer survival HR 3.4. However, such outcome was not statistically significant (p = 0.1360). Conclusions: The status at time of transplant with new methods for evaluation of minimal residual disease may help in assessing outcome. Larger prospective studies investigating innovative regimens is warranted. No significant financial relationships to disclose.

Management of Peripheral T-Cell Lymphoma in Children and Adolescents Including STAT 3 Mutation Hyper-IgE Syndrome

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Nikila Ravichandran ◽  
Ramya Uppuluri ◽  
Venkateswaran Vellaichamy Swaminathan ◽  
Kesavan Melarcode Ramanan ◽  
Satishkumar Meena ◽  
...  
Keyword(s):  
T Cell ◽  
Children And Adolescents ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma ◽  
Hyper Ige Syndrome

Retrospective analysis of non-anaplastic peripheral T-cell lymphoma in pediatric patients in Japan

2009 ◽  
pp. n/a-n/a ◽  
Author(s):  
Ryoji Kobayashi ◽  
Kazumi Yamato ◽  
Fumiko Tanaka ◽  
Yoshifumi Takashima ◽  
Hiroko Inada ◽  
...  
Keyword(s):  
T Cell ◽  
Retrospective Analysis ◽  
Pediatric Patients ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma

scholarly journals Peripheral T-cell lymphoma, unspecified - the analysis of the data from the Czech Lymphoma Study Group (CLSG) registry

2007 ◽  
Vol 151 (1) ◽  
pp. 103-107 ◽  
Author(s):  
Vit Prochazka ◽  
Marek Trneny ◽  
Robert Pytlik ◽  
Ingrid Vasova ◽  
Zdenek Kral ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Study Group ◽  
Peripheral T Cell Lymphoma ◽  
Lymphoma Study Group

A Retrospective Analysis of Peripheral T-Cell Lymphoma Treated With the Intention to Transplant in the First Remission

2013 ◽  
Vol 13 (6) ◽  
pp. 664-670 ◽  
Author(s):  
Neha Mehta ◽  
Jocelyn C. Maragulia ◽  
Allison Moskowitz ◽  
Paul A. Hamlin ◽  
Matthew A. Lunning ◽  
...  
Keyword(s):  
T Cell ◽  
Retrospective Analysis ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Peripheral T Cell Lymphoma ◽  
First Remission
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