scholarly journals Safety and clinical activity of 5-aza-2′-deoxycytidine (decitabine) with or without Hyper-CVAD in relapsed/refractory acute lymphocytic leukaemia

2014 ◽  
Vol 167 (3) ◽  
pp. 356-365 ◽  
Author(s):  
Christopher B. Benton ◽  
Deborah A. Thomas ◽  
Hui Yang ◽  
Farhad Ravandi ◽  
Michael Rytting ◽  
...  
Keyword(s):  
Lymphocytic Leukaemia ◽  
Clinical Activity ◽  
Acute Lymphocytic Leukaemia

Cytokinetic studies in children with untreated acute lymphocytic leukaemia (ALL): Relationship to “T” cell markers

1978 ◽  
Vol 5 (1) ◽  
pp. 177-182 ◽  
Author(s):  
H. Ekert ◽  
B. Dobrostanski ◽  
D. G. Jose ◽  
K. D. Waters ◽  
W. M. Ellis
Keyword(s):  
T Cell ◽  
Lymphocytic Leukaemia ◽  
Acute Lymphocytic Leukaemia ◽  
Cell Markers

Acute lymphocytic leukaemia with t(4;11): A clinical subentity

2009 ◽  
Vol 35 (1) ◽  
pp. 96-101 ◽  
Author(s):  
Ole Weis Bjerrum ◽  
Preben Philip ◽  
Nicole Müller-Bérat ◽  
Henrik Hertz ◽  
Sven-Aage Killmann
Keyword(s):  
Lymphocytic Leukaemia ◽  
Acute Lymphocytic Leukaemia

Thoracolumbar myelopathy with diffuse vertebral involvement in a dog secondary to aleukaemic lymphocytic leukaemia

2019 ◽  
Vol 7 (3) ◽  
pp. e000852
Author(s):  
Caitlin Elizabeth Doran ◽  
Simon Platt ◽  
Vivian Lau ◽  
Melinda Camus
Keyword(s):  
Clinical Presentation ◽  
Lymphocytic Leukaemia ◽  
Intrathecal Chemotherapy ◽  
High Rate ◽  
Neurological Involvement ◽  
Neurological Sequela ◽  
Mri Findings ◽  
Acute Lymphocytic Leukaemia ◽  
Clinical Presentations ◽  
Vertebral Involvement

Incidence rate of lymphocytic leukaemia is unknown in canine patients; neurological manifestations and imaging findings are rarely reported. In human medicine, acute lymphocytic leukaemia is known to have a high rate of meningeal metastasis prompting the use of intrathecal chemotherapy for newly diagnosed cases regardless of neurological signs. This report documents the clinical presentation and diagnostic findings in a dog presenting with paraparesis and pain, ultimately diagnosed with aleukaemic lymphocytic leukaemia. MRI findings with diffuse vertebral involvement secondary to lymphocytic leukaemia have not been documented in the veterinary literature. This report adds to the clinical presentations of leukaemia in canines and highlights a neurological sequela of the disease. Further investigation into neurological involvement of leukaemia is needed in veterinary medicine and necropsy, with meningeal histopathology, is recommended for all cases of acute lymphocytic leukaemia in canines to assess the metastatic rate and direct further research.

scholarly journals A Case of Acute Lymphocytic Leukaemia with t(3;13) and Central Nervous System Leukemia after Allogenic Cord Blood Transplantation

Cell Medicine ◽  
2019 ◽  
Vol 11 ◽  
pp. 215517901987385
Author(s):  
Xiaofan Li ◽  
Yaqun Hong ◽  
Jiafu Huang ◽  
Nainong Li
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cord Blood ◽  
Lymphocytic Leukaemia ◽  
Cord Blood Transplantation ◽  
Chromosomal Translocations ◽  
Leukemic Cells ◽  
Acute Lymphocytic Leukaemia ◽  
Blood Transplantation ◽  
Central Nervous System Leukemia

Background: Acute lymphoblastic leukemia (ALL) is a neoplastic cancer characterized by clonal expansion of leukemic cells in lymph organs and bone marrow. Lots of kinds of different chromosomal translocations can be found in those leukemic cells. However, the role of abnormal chromosomes and genes in leukemogenesis is not yet fully understood. Identifying new chromosomal translocations can facilitate a better understanding of pathogenesis of this disease. Case presentation: We report a rare case of acute lymphocytic leukaemia with t(3;13)(q29, q21). The patient was diagnosed pre-B-ALL with no abnormal chromosomal or gene fusion and achieved complete remission (CR) after induction chemotherapy; 10 months later, she relapsed in the consolidation, with cytogenetics tests showing 46, XX, t(3;13)(q29, q21). Given no CR after two chemotherapy regimens, the patient received salvage cord blood transplantation. Regular intrathecal methotrexate was applied to prevent central nervous system leukemia. Good graft versus leukemia was induced by daily injection of a low dose of IL-2 2 months post-transplantation. Minimal residual disease negativity was maintained until central nervous system (CNS) leukemia was found 8 months after transplantation. A whole exome sequencing was performed. Nine driver mutation genes and seven tumor genes were found. Conclusions: We highly suspect that the relapse in the CNS after transplantation is associated with a rare chromosomal translocation.

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