scholarly journals Clinical relevance of molecular aberrations in paediatric acute myeloid leukaemia at first relapse

2014 ◽  
Vol 166 (6) ◽  
pp. 902-910 ◽  
Author(s):  
Costa Bachas ◽  
Gerrit Jan Schuurhuis ◽  
Dirk Reinhardt ◽  
Ursula Creutzig ◽  
Zinia J. Kwidama ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Clinical Relevance ◽  
First Relapse ◽  
Molecular Aberrations ◽  
Acute Myeloid

Clinical Management of Relapsed/Refractory Acute Myeloid Leukaemia

2010 ◽  
Vol 00 (04) ◽  
pp. 43
Author(s):  
Sameer A Parikh ◽  
Stefan Faderl ◽  
◽  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Dose Schedule ◽  
Conventional Chemotherapy ◽  
Curative Therapy ◽  
Flt3 Inhibitors ◽  
First Relapse ◽  
Definition Of ◽  
Molecular Aberrations ◽  
Acute Myeloid

Conventional chemotherapy for patients with relapsed/refractory acute myeloid leukaemia (AML) remains unsatisfactory, with median survival ranging from 18 weeks following first relapse to six weeks in those with a second or higher relapse. The only potentially curative therapy is stem cell transplantation. Duration of first complete remission (CR) is the best predictor of response to salvage therapy. Novel therapies directed against a number of molecular aberrations associated with AML are being developed, including anti-CD33 monoclonal antibodies, FMS-like tyrosine kinase (FLT3) inhibitors, nucleoside analogues, hypomethylating agents and histone deacetylatase inhibitors, among others. Clinical trials combining novel agents with conventional chemotherapy are of particular interest, and definition of dose, schedule and combination partners remains an area of intense research.

scholarly journals Clinical relevance of mutant NPM1 and CEBPA in patients with acute myeloid leukaemia – preliminary report

2014 ◽  
Vol 4 ◽  
pp. 241-245 ◽  
Author(s):  
Grzegorz Helbig ◽  
Krzysztof Wozniczka ◽  
Agnieszka Wieclawek ◽  
Anna Soja ◽  
Aleksandra Bartkowska-Chrobok ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Clinical Relevance ◽  
Preliminary Report ◽  
Acute Myeloid

scholarly journals Clinical relevance of failed and missing cytogenetic analysis in acute myeloid leukaemia

Leukemia ◽  
2017 ◽  
Vol 31 (5) ◽  
pp. 1234-1237 ◽  
Author(s):  
L Chilton ◽  
C J Harrison ◽  
I Ashworth ◽  
D Murdy ◽  
A K Burnett ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Clinical Relevance ◽  
Cytogenetic Analysis ◽  
Acute Myeloid

scholarly journals Partial response after induction chemotherapy has clinical relevance in acute myeloid leukaemia

2016 ◽  
Vol 177 (2) ◽  
pp. 328-330 ◽  
Author(s):  
Shaun Fleming ◽  
Doen Ming Ong ◽  
Kathryn Jackson ◽  
Sharon Avery ◽  
Peter Mollee ◽  
...  
Keyword(s):  
Partial Response ◽  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Induction Chemotherapy ◽  
Clinical Relevance ◽  
Acute Myeloid

Surface marker expression in acute myeloid leukaemia at first relapse

1992 ◽  
Vol 81 (1) ◽  
pp. 40-44 ◽  
Author(s):  
Xavier Thomas ◽  
Lydia Campos ◽  
Eric Archimbaud ◽  
Zhi-Hua Shi ◽  
Danièle Treille-Ritouet ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Surface Marker ◽  
Surface Marker Expression ◽  
First Relapse ◽  
Marker Expression ◽  
Acute Myeloid

scholarly journals Validation of the European Prognostic Index for younger adult patients with acute myeloid leukaemia in first relapse

2006 ◽  
Vol 134 (1) ◽  
pp. 58-60 ◽  
Author(s):  
Francis Giles ◽  
Srdan Verstovsek ◽  
Guillermo Garcia-Manero ◽  
Deborah Thomas ◽  
Farhad Ravandi ◽  
...  
Keyword(s):  
Acute Myeloid Leukaemia ◽  
Myeloid Leukaemia ◽  
Prognostic Index ◽  
Adult Patients ◽  
First Relapse ◽  
Acute Myeloid
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