scholarly journals NOTCH1mutations are associated with favourable long-term prognosis in paediatric T-cell acute lymphoblastic leukaemia: a retrospective study of patients treated on BCH-2003 and CCLG-2008 protocol in China

2014 ◽  
Vol 166 (2) ◽  
pp. 221-228 ◽  
Author(s):  
Chao Gao ◽  
Shu-Guang Liu ◽  
Rui-Dong Zhang ◽  
Wei-Jing Li ◽  
Xiao-Xi Zhao ◽  
...  
Keyword(s):  
Retrospective Study ◽  
T Cell ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Long Term Prognosis

scholarly journals NELARABINE TREATMENT IN ADULT PATIENTS WITH REFRACTORY/ RELAPSED T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA/LYMPHOMA: EXPERIENCE OF A SINGLE CENTRE

2019 ◽  
Vol 64 (4) ◽  
pp. 382-395
Author(s):  
O. A. Gavrilina ◽  
E. S. Kotova ◽  
E. N. Parovichnikova ◽  
V. V. Troitskaya ◽  
A. N. Sokolov ◽  
...  
Keyword(s):  
T Cell ◽  
Acute Lymphoblastic Leukaemia ◽  
Conflict Of Interest ◽  
Lymphoblastic Leukaemia ◽  
Infectious Complications ◽  
Adult Patients ◽  
Long Term Results ◽  
Single Centre ◽  
Poor Efficacy

Introduction. Modern therapy for relapses and resistant forms of T-cell acute lymphoblastic leukaemia/lymphoma (T-ALL/ LBL) shows poor efficacy. The use of nelarabine can improve the results of therapy in patients with refractory/relapsed T-ALL/LBL.Aim. To evaluate the efficacy and toxicity of nelarabine treatment combined with etoposide and cyclophosphamide in adult patients with refractory/relapsed T-ALL/LBL.Materials and methods. During the 2012–2018 period, 10 patients with refractory/relapsed T-ALL aged from 19 to 41 underwent nelarabine treatment. The patients received from 1 to 3 chemotherapy courses including nelarabine 650 mg/m2 (days 1 to 5), etoposide 100 mg/m2 and cyclophosphamide 440 mg/m2 (days 8 to 12). All the patients having achieved complete remission (СR) underwent transplantation of allogeneic haematopoietic stem cells (allo-HSCT). The development of toxic sequelae (myelosuppression, neurotoxicity, incidence of infectious complications) was considered after each chemotherapy course.Results. Out of 10 patients who received 1–2 chemotherapy courses, 6 (60 %) achieved CR. These 6 patients subsequently underwent allo-HSCT, which was followed by early relapse in 3 (50 %) of 6 patients and the death of 1 patient in persisting CR caused by infectious complications. Only 2 of 6 patients have been monitored for 1.5 years after the allo-HSCT. The five-year overall survival rate in relapsed patients came to 18 %. In terms of toxic sequelae, myelosuppression and infectious complications were observed in all patients. Neurotoxicity was noted in 3 (30 %) out of 10 patients, with two of them experiencing it after each course and one patient — only following the third course of nelarabine treatment.Conclusion. The use of nelarabine for the treatment of refractory/relapsed T-ALL/LBL provides the opportunity to achieve CR in 60 % of cases, as well as to perform allo-HSCT. However, long-term results are not very optimistic, thus further research is required.Conflict of interest: the authors declare no conflict of interest.Financial disclosure: the study had no sponsorship.

scholarly journals T cell acute lymphoblastic leukaemia presenting with sudden onset right oculomotor nerve palsy with normal neuroradiography and cerebrospinal fluid studies

2012 ◽  
Vol 2012 (mar26 1) ◽  
pp. bcr0120125685-bcr0120125685
Author(s):  
V. R. Bhatt ◽  
M. Naqi ◽  
R. Bartaula ◽  
S. Murukutla ◽  
S. Misra ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
T Cell ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Nerve Palsy ◽  
Sudden Onset ◽  
Oculomotor Nerve ◽  
Oculomotor Nerve Palsy

scholarly journals PF163 TARGETING LYSOSOMES AS A POTENTIAL THERAPEUTIC APPROACH FOR T-CELL ACUTE LYMPHOBLASTIC LEUKAEMIA

HemaSphere ◽  
2019 ◽  
Vol 3 (S1) ◽  
pp. 33-34
Author(s):  
A. Banus Mulet ◽  
J.M. Cornet-Masana ◽  
J.M. Carbó ◽  
L. Cuesta-Casanovas ◽  
F. Guijarro ◽  
...  
Keyword(s):  
T Cell ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Therapeutic Approach

T-cell acute lymphoblastic leukaemia with late developing Philadelphia chromosome

1984 ◽  
Vol 56 (1) ◽  
pp. 139-146 ◽  
Author(s):  
Barbara A. Miller ◽  
Michael M. Reid ◽  
Marilyn Nell ◽  
Jeffrey M. Lipton ◽  
Stephen E. Sallan ◽  
...  
Keyword(s):  
T Cell ◽  
Acute Lymphoblastic Leukaemia ◽  
Lymphoblastic Leukaemia ◽  
Philadelphia Chromosome
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