scholarly journals Impact of glucose-6-phosphate dehydrogenase deficiency on sickle cell anaemia expression in infancy and early childhood: a prospective study

2013 ◽  
Vol 163 (5) ◽  
pp. 646-654 ◽  
Author(s):  
Malika Benkerrou ◽  
Corinne Alberti ◽  
Nathalie Couque ◽  
Zinedine Haouari ◽  
Aissatou Ba ◽  
...  
Keyword(s):  
Early Childhood ◽  
Prospective Study ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Dehydrogenase Deficiency ◽  
Infancy And Early Childhood ◽  
A Prospective Study ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Effects of Glucose-6-Phosphate Dehydrogenase Deficiency upon Sickle Cell Anaemia

1989 ◽  
Vol 26 (6) ◽  
pp. 477-480 ◽  
Author(s):  
A K Al-Ali ◽  
M A M Ahmed ◽  
H Al-Idrissi ◽  
M H Al-Sibai ◽  
A R Al-Mutairy ◽  
...  
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Dehydrogenase Deficiency ◽  
Glycated Haemoglobin ◽  
Survival Advantage ◽  
Fetal Haemoglobin ◽  
Significant Difference ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
Normal Controls

The levels of glycated haemoglobin, fetal haemoglobin and methaemoglobin in 618 Saudi subjects were determined. A statistically significant decrease in the percentage of glycated haemoglobin was observed in all haemoglobinopathic groups studied in comparison to normal controls. However, there was no significant difference in the percentage of glycated haemoglobin in patients with sickle cell anaemia when compared with those sickle cell subjects who were also glucose-6-phosphate dehydrogenase deficient. This suggests that there is little survival advantage or disadvantage in the combination of glucose-6-phosphate dehydrogenase deficiency and sickle cell anaemia.

scholarly journals Impact of Glucose-6-phosphate Dehydrogenase Deficiency on Sickle Cell Anaemia Expression: A Case Report

2020 ◽  
Vol 8 (3) ◽  
pp. 102
Author(s):  
Patrick Olanrewaju Osho ◽  
Matilda Adesuwa Osagie Ojo ◽  
Evelyn Salewa Osho ◽  
Ndidi Aisha Okunnuga ◽  
Oluwatosin Idowu Oni ◽  
...  
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anaemia ◽  
Dehydrogenase Deficiency ◽  
Glucose 6 Phosphate Dehydrogenase

scholarly journals Neuropathic Pain in Children with Sickle Cell Disease: The Hidden Side of the Vaso-Occlusive Crisis

Children ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 84
Author(s):  
Jeanne Sigalla ◽  
Nathalie Duparc Alegria ◽  
Enora Le Roux ◽  
Artemis Toumazi ◽  
Anne-Françoise Thiollier ◽  
...  
Keyword(s):  
Risk Factors ◽  
Neuropathic Pain ◽  
Sickle Cell Disease ◽  
Sex Ratio ◽  
Prospective Study ◽  
Sickle Cell ◽  
Clinical Presentation ◽  
Early Stage ◽  
Cell Disease ◽  
A Prospective Study

The majority of hospitalizations of patients with sickle cell disease (SCD) are related to painful vaso-occlusive crises (VOCs). Although the pain of VOC is classically nociceptive, neuropathic pain (NP) has also been demonstrated in SCD patients. The aim of our study is to specify the prevalence of NP during VOCs in SCD children using a dedicated scale and to measure its characteristics. We performed a prospective study that included SCD children hospitalized for an acute VOC. The presence of NP was sought with the DN4 scale on the second and fourth days of hospitalization. A total of 54 SCD children were included in the study. Overall, 41% of the patients (n = 22) experienced neuropathic pain during the VOC, mostly at an early stage (Day 2). The median age, the sex ratio, the location of the pain, and the morphine consumption were similar for patients with and without NP. Our study shows that neuropathic pain is very common during VOCs in SCD children. The absence of identified risk factors should prompt us to be vigilant regardless of the patient’s age, sex, and clinical presentation.

Patterns of Sickle Cell, Thalassaemia and Glucose-6-Phosphate Dehydrogenase Deficiency Genes in North-Western Saudi Arabia

1991 ◽  
Vol 41 (1) ◽  
pp. 26-34 ◽  
Author(s):  
M.A.F. El-Hazmi ◽  
F.A. Jabbar ◽  
Faleh Z. Al-Faleh ◽  
A.R. Al-Swailem ◽  
A.S. Warsy
Keyword(s):  
Saudi Arabia ◽  
Sickle Cell ◽  
Dehydrogenase Deficiency ◽  
Glucose 6 Phosphate Dehydrogenase ◽  
North Western
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